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61.
62.
H. Hakan Coskun Alfio Ferlito Jesus E. Medina K. Thomas Robbins Juan P. Rodrigo Primo Strojan Carlos Surez Robert P. Takes Julia A. Woolgar Ashok R. Shaha Remco de Bree Alessandra Rinaldo Carl E. Silver 《Head & neck》2011,33(10):1520-1529
Retropharyngeal lymph node (RPLN) metastasis of primary head and neck cancer often receives less consideration than lymph node metastasis in the neck. With improvements in imaging techniques and reports of surgical pathology, there is an improved understanding of the risk and subsequently the need for treatment of RPLNs. The rates of RPLN metastasis from carcinomas of the nasopharynx, oropharynx, hypopharynx, postcricoid region, maxillary sinus, and cervical esophagus are sufficiently high to warrant routine treatment, either electively or therapeutically, of this region. Through improved diagnostic techniques and heightened awareness of RPLN metastasis, patients at risk of having these metastases can be treated more effectively. © 2010 Wiley Periodicals, Inc. Head Neck, 2010 相似文献
63.
Ferlito A Robbins KT Shah JP Medina JE Silver CE Al-Tamimi S Fagan JJ Paleri V Takes RP Bradford CR Devaney KO Stoeckli SJ Weber RS Bradley PJ Suárez C Leemans CR Coskun HH Pitman KT Shaha AR de Bree R Hartl DM Haigentz M Rodrigo JP Hamoir M Khafif A Langendijk JA Owen RP Sanabria A Strojan P Vander Poorten V Werner JA Bień S Woolgar JA Zbären P Betka J Folz BJ Genden EM Talmi YP Strome M González Botas JH Olofsson J Kowalski LP Holmes JD Hisa Y Rinaldo A 《Head & neck》2011,33(3):445-450
64.
Jesus E. Medina MD Alfio Ferlito MD DLO DPath FRCSEd ad hominem FRCS ad eundem FDSRCS ad eundem FHKCORL FRCPath FASCP IFCAP K. Thomas Robbins MD FRCSC Carl E. Silver MD Juan P. Rodrigo MD PhD Remco de Bree MD Mohamed N. Elsheikh MD Randal S. Weber MD Jochen A. Werner MD 《Head & neck》2011,33(5):746-752
We report here a review of the literature intended to clarify the nomenclature and boundaries of the nodes in the “central compartment” of the neck, the frequency with which tumors from the different laryngeal sites metastasize to these nodes, and the indications for central compartment node dissection in the treatment of cancers of the larynx. From this review, we conclude that, until consensus is reached about grouping of the lymph nodes in this area, it is best to refer to these nodes by their anatomic location, ie, prelaryngeal, pretracheal, or paratracheal lymph nodes. It is also advisable to describe dissection of these nodes as selective neck dissection (SND) with an annotation about the specific lymph node groups removed. Metastases in prelaryngeal and paratracheal lymph nodes in patients with squamous cell carcinoma of the larynx are associated with increased tumor recurrence, more frequent metastases in lymph nodes of the lateral compartment of the neck, and decreased survival. If untreated, they may lead to the development of peristomal recurrence. Therefore, elective treatment of level VI nodes is recommended in patients with squamous cell carcinomas of the subglottic region, advanced glottis carcinomas with subglottic extension, and in certain advanced carcinomas of the supraglottic region. © 2010 Wiley Periodicals, Inc. Head Neck, 2011 相似文献
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66.
BACKGROUND: Thoracic duct cysts of the cervical portion are rare benign lesions for which surgery is the treatment of choice. METHODS: We present 2 cases of a thoracic duct cyst of the cervical portion. One patient was treated by surgery and the other patient by ethanol sclerotherapy. RESULTS: After establishing diagnosis by radiologic assessment and chemical and cytological fine-needle aspirate of the cystic masses, both patients were treated successfully. CONCLUSION: Ethanol sclerotherapy provides an alternative therapy for thoracic duct cyst when evaluation establishes a high likelihood of clinical diagnosis. 相似文献
67.
Jordan Douglas Jemma L. Geoghegan James Hadfield Remco Bouckaert Matthew Storey Xiaoyun Ren Joep de Ligt Nigel French David Welch 《Emerging infectious diseases》2021,27(9):2361
Since severe acute respiratory syndrome coronavirus 2 was first eliminated in New Zealand in May 2020, a total of 13 known coronavirus disease (COVID-19) community outbreaks have occurred, 2 of which led health officials to issue stay-at-home orders. These outbreaks originated at the border via isolating returnees, airline workers, and cargo vessels. Because a public health system was informed by real-time viral genomic sequencing and complete genomes typically were available within 12 hours of community-based positive COVID-19 test results, every outbreak was well-contained. A total of 225 community cases resulted in 3 deaths. Real-time genomics were essential for establishing links between cases when epidemiologic data could not do so and for identifying when concurrent outbreaks had different origins. 相似文献
68.
Rationale
Since implicit attitudes toward alcohol play an important role in drinking behavior, a possible way to obtain a behavioral change is changing these implicit attitudes. 相似文献69.
Sakai H Visser R Ikegawa S Ito E Numabe H Watanabe Y Mikami H Kondoh T Kitoh H Sugiyama R Okamoto N Ogata T Fodde R Mizuno S Takamura K Egashira M Sasaki N Watanabe S Nishimaki S Takada F Nagai T Okada Y Aoka Y Yasuda K Iwasa M Kogaki S Harada N Mizuguchi T Matsumoto N 《American journal of medical genetics. Part A》2006,140(16):1719-1725
In order to evaluate the contribution of FBN1, FBN2, TGFBR1, and TGFBR2 mutations to the Marfan syndrome (MFS) phenotype, the four genes were analyzed by direct sequencing in 49 patients with MFS or suspected MFS as a cohort study. A total of 27 FBN1 mutations (22 novel) in 27 patients (55%, 27/49), 1 novel TGFBR1 mutation in 1 (2%, 1/49), and 2 recurrent TGFBR2 mutations in 2 (4%, 2/49) were identified. No FBN2 mutation was found. Three patients with either TGFBR1 or TGFBR2 abnormality did not fulfill the Ghent criteria, but expressed some overlapping features of MFS and Loeys-Dietz syndrome (LDS). In the remaining 19 patients, either of the genes did not show any abnormalities. This study indicated that FBN1 mutations were predominant in MFS but TGFBRs defects may account for approximately 5-10% of patients with the syndrome. 相似文献
70.
Faster identification of pathogens in positive blood cultures by fluorescence in situ hybridization in routine practice
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Peters RP Savelkoul PH Simoons-Smit AM Danner SA Vandenbroucke-Grauls CM van Agtmael MA 《Journal of clinical microbiology》2006,44(1):119-123
Rapid identification of microorganisms in blood cultures is required to optimize empirical treatment at an early stage. Fluorescence in situ hybridization (FISH) can reduce the time to identification of microorganisms in growth-positive blood cultures. In this study, we evaluated the performance, time to identification, and potential clinical benefits of FISH compared to those of conventional culture methods in routine practice. After Gram staining, blood culture fluids were simultaneously further identified with FISH and with conventional culture methods. Results and points in time of FISH and culture identification (provisional and final identifications) were collected and compared. For 91% of microorganisms, the genus or family name was identified, and for 79%, the species name could be attributed. The sensitivity and specificity of the individual probes exceeded 95%, except for the Enterobacteriaceae probe (sensitivity, 89%). Cross-hybridization was obtained with the Klebsiella pneumoniae probe for Klebsiella oxytoca. The time gains of FISH and final culture identification were more than 18 h for bacteria and 42 h for yeasts. With FISH, Staphylococcus aureus was differentiated from coagulase-negative staphylococci 1.4 h faster than by provisional identification (P < 0.001). In conclusion, FISH allows rapid and reliable identification of the majority of microorganisms in growth-positive blood cultures. The substantial time gain of identification with FISH may allow same-day adjustment of antimicrobial therapy, and FISH is especially useful if no provisional identification is obtained. With further extension of the number of probes and a reduction in turnaround time, FISH will become a very useful diagnostic tool in the diagnosis of bloodstream infections. 相似文献