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991.
Hitoshi Kawazoe Akari Murakami Michiko Yamashita Kanako Nishiyama Kana Kobayashi-Taguchi Saaya Komatsu Reina Aoki Erina Kusakabe Haruna Yamasawa Yoshihiro Yakushijin Tomonori Nakamura Yoshiaki Kamei 《Clinical therapeutics》2018,40(12):2170-2179
Purpose
The aim of this study was to identify a high-risk or low-risk population for chemotherapy-induced nausea and vomiting among patients with breast cancer treated with a current standard 3-drug antiemetic regimen and receiving anthracycline.Methods
We analyzed data from chemotherapy-naive Japanese patients with breast cancer, who had received the first cycle of anthracycline-based regimen and were treated with a 3-drug combination of aprepitant, palonosetron, and dexamethasone. This study was carried out at Ehime University Hospital (Toon, Japan) using electronic medical records from May 2011 to June 2017. The primary end point was complete response (CR), which was defined as no emesis and no use of rescue medication.Findings
A total of 103 patients were included in this study. The percentages of patients who had a CR in the overall, acute, and delayed phases were 35.0%, 40.8%, and 50.5%, respectively. Multivariate logistic regression analysis revealed that age <55 years and body mass index <27.5 kg/m2 were significantly associated with an increased risk for CR failure in the overall and acute phases. In contrast, a history of alcohol habit was significantly associated with a decreased risk for CR failure in overall phase.Implications
The present findings suggest that, among patients with breast cancer receiving anthracycline and treated with aprepitant, palonosetron, and dexamethasone, patients younger than 55 years and having a body mass index <27.5 kg/m2 are high-risk populations for chemotherapy-induced nausea and vomiting, whereas those with a history of habitual alcohol consumption is a low-risk one. 相似文献992.
Isomer pattern and elimination of dioxins in workers exposed at a municipal
waste incineration plant
Kenya YAMAMOTO Mitsuhiro KUDO Heihachiro ARITO Yasutaka OGAWA Tsutomu TAKATA 《Industrial health》2015,53(5):454-464
The aim of this study was to clarify patterns of serum concentrations of
dioxins in the employees of a waste incineration plant and to estimate elimination rates
and half-lives of serum dioxin isomers, and the maximum serum concentrations of dioxin
isomers at the time of plant shutdown. Sixteen subjects participating 3 times or more in
annual health examinations during an 8-yr period from 2000 to 2007 were recruited for this
study. Serum concentrations of dioxins expressed as TEQ/g lipid decreased gradually after
plant shutdown with the highest decrease observed in polychlorinated dibenzofurans (PCDFs)
followed by polychlorinated deibenzo-p-dioxins (PCDDs) and then coplanar PCBs. The serum
toxic equivalency (TEQ) concentrations of PCDF and PCDD congeners in the employees were
higher than those in the general population survey by the Ministry of the Environment,
Japan, whereas the serum concentrations of coplanar PCBs were similar to those in the
general population. The estimated half-lives and elimination rates of PCDDs and PCDFs in
the highly exposed workers increased compared with the moderately exposed workers. The
estimated geometric mean serum concentrations of PCDDs, PCDFs and total dioxins at the
time of plant shutdown were 35, 53 and 107 pg TEQ/g lipid, respectively. 相似文献
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Jiménez Ruiz CA Flórez Martín S Ramos Pineda A Lorza JJ Hernández-Mezquita MA Solano Reina S Barrueco Ferrero M 《Archivos de bronconeumología》1999,35(11):535-538
We have carried out an open multicenter follow-up study of the efficacy of a smoking cessation therapy that combined psychological support with use of a nicotine nasal spray. Fifty-seven subjects (37 men, 20 women) with a mean age of 40.3 +/- 15.7 yr and smoking 37.4 +/- 4.7 cigarettes per day were enrolled. The mean Fagerstr?m test score was 8.9 +/- 1.1. Patients received minimal psychological support and were prescribed a nicotine nasal spray at the recommended dose of 1 to mg/h for use while awake for a period of three months, with gradual reduction of dose. Subjects were seen on six occasions (on the first day of consultation; 1, 2 and 6 weeks after quitting; 3 and 6 months after quitting). After three months of follow-up, 22 patients (39%) were abstinent; six months after first trying to quit, only 20 of the 57 enrolled had succeeded (35%). Although most subjects (over 90% in the first 15 days, and over 50% at three months) used the treatment, only a small percentage (3%) followed the appropriate doses in the first 15 days and 31% reported doing so at the three-month check-up. The mean score reflecting withdrawal syndrome tripled over baseline level during the first six weeks of follow-up. Over three quarters of the subjects suffered side effects caused by the spray, the most common being nasal irritation, rhinorrhea and tearing. Five patients (87%) lef the study because of intolerance to medication. In conclusion, our study found a rate of success of 35% after six months of follow-up. Use of the prescribed medication was inadequate; withdrawal syndrome was more intense and the prevalence of side effects increased during the early treatment period. 相似文献
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998.
Vanaga S van der Heide R Joffe R van der Poel WH 《Vector borne and zoonotic diseases (Larchmont, N.Y.)》2003,3(3):117-124
In the Baltic States, lyssaviruses are often detected in wildlife and presumed to constitute an important public health hazard. In order to decrease rabies incidence and eradicate wildlife reservoirs, a national rabies eradication program has been in place. Since 1970 a vaccination program in dogs and cats has been executed, and in 1991 oral vaccination of foxes was started. However, due to an insufficient budget, the latter was not done regularly and nationwide before 2000. Now, the program in force consists of compulsory vaccination of all dogs and cats, and a tetracycline marker vaccine oral vaccination program of foxes in the whole country. In 2001, 151 of 285 (53%) fox jaws were tested positive for tetracycline. All animals showing rabies-like symptoms were killed and tested for rabies. In this way, 250-400 cases of rabies per year were diagnosed in wildlife. To molecularly characterize the prevalent lyssaviruses in wildlife, lyssavirus RNA of 25 recent rabies positive samples, collected in the year 1999, was amplified by RT-PCR. Direct sequencing of the RT-PCR-amplified products of the virus' nucleoprotein encoding region and subsequent sequence analyses resulted in a 99.3-100% homology between isolates and a 99.0-100% similarity with a 1995 genotype I, classical rabies virus (RABV) raccoon dog isolate from Estonia. These results confirmed that RABV is endemic in wildlife in Latvia and should be considered a serious public health threat. To successfully eradicate the wildlife reservoirs, the national rabies eradication program must be continued, and it may need to be intensified. 相似文献
999.