全文获取类型
收费全文 | 4994篇 |
免费 | 341篇 |
国内免费 | 72篇 |
专业分类
耳鼻咽喉 | 93篇 |
儿科学 | 218篇 |
妇产科学 | 44篇 |
基础医学 | 482篇 |
口腔科学 | 64篇 |
临床医学 | 623篇 |
内科学 | 974篇 |
皮肤病学 | 54篇 |
神经病学 | 627篇 |
特种医学 | 438篇 |
外科学 | 602篇 |
综合类 | 141篇 |
一般理论 | 2篇 |
预防医学 | 495篇 |
眼科学 | 41篇 |
药学 | 301篇 |
2篇 | |
肿瘤学 | 206篇 |
出版年
2022年 | 25篇 |
2021年 | 71篇 |
2020年 | 58篇 |
2019年 | 89篇 |
2018年 | 109篇 |
2017年 | 80篇 |
2016年 | 71篇 |
2015年 | 105篇 |
2014年 | 111篇 |
2013年 | 184篇 |
2012年 | 219篇 |
2011年 | 241篇 |
2010年 | 168篇 |
2009年 | 158篇 |
2008年 | 209篇 |
2007年 | 255篇 |
2006年 | 233篇 |
2005年 | 188篇 |
2004年 | 175篇 |
2003年 | 197篇 |
2002年 | 175篇 |
2001年 | 161篇 |
2000年 | 142篇 |
1999年 | 137篇 |
1998年 | 109篇 |
1997年 | 110篇 |
1996年 | 105篇 |
1995年 | 99篇 |
1994年 | 72篇 |
1993年 | 83篇 |
1992年 | 96篇 |
1991年 | 83篇 |
1990年 | 92篇 |
1989年 | 100篇 |
1988年 | 73篇 |
1987年 | 96篇 |
1986年 | 71篇 |
1985年 | 73篇 |
1984年 | 58篇 |
1983年 | 89篇 |
1982年 | 40篇 |
1981年 | 46篇 |
1980年 | 38篇 |
1979年 | 30篇 |
1978年 | 24篇 |
1977年 | 36篇 |
1975年 | 27篇 |
1974年 | 22篇 |
1973年 | 21篇 |
1971年 | 20篇 |
排序方式: 共有5407条查询结果,搜索用时 15 毫秒
101.
O'Day SJ; Rabinowe SN; Neuberg D; Freedman AS; Soiffer RJ; Spector NA; Robertson MJ; Anderson K; Whelan M; Pesek K 《Blood》1994,83(9):2707-2714
Recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) clearly hastens myeloid recovery in patients with relapsed hematologic malignancies undergoing autologous bone marrow transplantation (ABMT). In efforts to further improve neutrophil engraftment and shorten hospital stay in ABMT patients, rhGM-CSF was administered by a potentially more potent route (continuous infusion) to non-Hodgkin's lymphoma (NHL) patients with better BM reserve (first remission). Time to myeloid engraftment was compared with that of NHL patients treated in first remission at our institution on a similar ABMT protocol but without growth factor support (controls). Median neutrophil engraftment (absolute neutrophil count, 500 cells/microL) in first remission patients treated with rhGM-CSF was 14 days, compared with 22 days in controls (P = .0001). Hospital stays were also significantly reduced for rhGM-CSF patients (P = .0003). Platelet engraftment did not differ between the two groups. Persistent fever and generalized serositis were the primary toxicities. rhGM-CSF, delivered by this route, was efficacious but more toxic than 2-hour rhGM-CSF infusions previously reported by other investigators. Future alterations in both dose and schedule may retain comparable efficacy yet diminish toxicity. 相似文献
102.
103.
104.
105.
106.
107.
108.
Sarah A Stuart Paul Butler Marcus R Munafò David J Nutt Emma SJ Robinson 《Neuropsychopharmacology》2015,40(9):2165-2174
The biochemical targets for antidepressants are relatively well established, but we lack a clear understanding of how actions at these proteins translate to clinical benefits. This study used a novel rodent assay to investigate how different antidepressant drugs act to modify affective biases that have been implicated in depression. In this bowl-digging task, rats encounter two equal value learning experiences on separate days (one during an affective manipulation and the other during control conditions). This induces an affective bias that is quantified using a preference test in which both digging substrates are presented together and the individual rats’ choices recorded. The assay can be used to measure affective biases associated with learning (when the treatment is given at the time of the experience) or examine the modification of previously acquired biases (when the treatment is administered before the preference test). The rapid-onset antidepressant ketamine, but not the delayed-onset antidepressant, venlafaxine, attenuated the previously acquired FG7142-induced negative bias following systemic administration. Venlafaxine but not ketamine induced a positive bias when administered before learning. We then used local drug infusions and excitotoxic lesions to localize the effects of ketamine to the medial prefrontal cortex and venlafaxine to the amygdala. Using a modified protocol we also showed that positive and negative biases amplified further when the numbers of substrate–reinforcer associations are increased. We propose that this pattern of results could explain the delayed onset of action of venlafaxine and the rapid onset of action but lack of long-term efficacy seen with ketamine. 相似文献
109.
Anderson Kelley M. Ferranti Erin P. Alagha Emily Couvillon Mykityshyn Emma French Casey E. Reilly Carolyn Miller 《Heart failure reviews》2022,27(6):2223-2249
Heart Failure Reviews - There is an expanding body of research on the bidirectional relationship of the human gut microbiome and cardiovascular disease, including heart failure (HF). Researchers... 相似文献
110.