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131.
AmirAli Jafarnezhadgero Morteza Madadi Shad Reed Ferber 《Journal of bodywork and movement therapies》2018,22(1):83-89
Introduction
It has been widely postulated that structural and functional misalignments of the foot, such as flat foot, may cause mechanical deviations of the lower limb during walking. The aim of this study was to investigate the effect of foot orthoses on lower extremity joint moment asymmetry during the stance phase of walking in children with asymptomatic flexible flat feet.Methods
Fourteen volunteer male children, clinically diagnosed with flexible flat feet, participated in this study. Subjects completed 12 walking trials at a self-selected walking speed while 3-dimensional kinematic and kinetic data were collected for two conditions: shod with no orthoses, and shod with orthoses. The gait asymmetry index for each variable for each subject was defined as: (1-(lesser moment/greater moment)) × 100.Results
Results reveal no significant differences in ankle or knee joint moment asymmetry. However, the use of foot orthoses decreased asymmetry for the hip abduction moment (P = 0.04) compared to walking without orthoses and also resulted in subtle, non-significant increases in frontal plane subtalar and sagittal plane knee and hip joints moment asymmetry.Conclusion
We conclude that foot orthoses decrease frontal plane hip joint moment asymmetry, but have little effect on ankle and knee joint asymmetry. 相似文献132.
133.
Kelly L. Fargo Jessica Johnston Kurt B. Stevenson Meredith Deutscher Erica E. Reed 《Hospital pharmacy》2015,50(6):496-504
Background:
Studies evaluating the impact of passive cost visibility tools on antibiotic prescribing are lacking.Objective:
The objective of this study was to evaluate whether the implementation of a passive antibiotic cost visibility tool would impact antibiotic prescribing and decrease antibiotic spending.Methods:
An efficiency and effectiveness initiative (EEI) was implemented in October 2012. To support the EEI, an antibiotic cost visibility tool was created in June 2013 displaying the relative cost of antibiotics. Using an observational study of interrupted time series design, 3 time frames were studied: pre EEI, post EEI, and post cost visibility tool implementation. The primary outcome was antibiotic cost per 1,000 patient days. Secondary outcomes included case mix index (CMI)–adjusted antibiotic cost per 1,000 patient days and utilization of the cost visibility tool.Results:
Initiation of the EEI was associated with a $4,675 decrease in antibiotic cost per 1,000 patient days (P = .003), and costs continued to decrease in the months following EEI (P = .009). After implementation of the cost visibility tool, costs remained stable (P = .844). Despite CMI increasing over time, adjustment for CMI had no impact on the directionality or statistical significance of the results.Conclusion:
Our study demonstrated a significant and sustained decrease in antibiotic cost per 1,000 patient days when focused medication cost reduction efforts were implemented, but passive cost visibility tool implementation was not associated with additional cost reduction. Antibiotic cost visibility tools may be of most benefit when prior medication cost reduction efforts are lacking or when an active intervention is incorporated. 相似文献134.
Mbita Gaspar Komba Albert N. Casalini Caterina Bazant Eva Curran Kelly Christensen Alice Nyato Daniel Kim Young-Mi Reed Jason Makyao Neema Kategile Upendo Conserve Donaldson F. Faini Diana van Roosmalen Jos van den Akker Thomas 《AIDS and behavior》2022,26(10):3185-3198
AIDS and Behavior - The World Health Organization identified men as an essential group to target with HIV testing and treatment strategies;: men who have sex with men (MSM) and male clients of... 相似文献
135.
Reed Elizabeth West Brooke S. Frost Elizabeth Salazar Marissa Silverman Jay G. McIntosh Craig T. Gómez María Gudelia Rangel Urada Lianne A. Brouwer Kimberly C. 《AIDS and behavior》2022,26(10):3210-3219
AIDS and Behavior - Economic vulnerability is often reported to underlie involvement in sex work among female sex workers (FSW), but may also create urgency in women’s work, limiting... 相似文献
136.
Lee Michael H. Leda Mariela Buchan Tayler Malik Abdullah Rigobon Alanna Liu Helen Daza Julian F. O’Brien Kathleen Stein Madeleine Hing Nicholas Ng Fat Siemeiniuk Reed Sekercioglu Nigar Evaniew Nathan Foroutan Farid Ross Heather Alba Ana Carolina 《Heart failure reviews》2022,27(2):455-464
Heart Failure Reviews - Previous primary studies have explored the association between blood pressure (BP) and mortality in ambulatory heart failure (HF) patients reporting varying and contrasting... 相似文献
137.
138.
Reed HL Reedy KR Palinkas LA Van Do N Finney NS Case HS LeMar HJ Wright J Thomas J 《The Journal of clinical endocrinology and metabolism》2001,86(1):110-116
Humans who work in Antarctica display deficits in cognition, disturbances in mood, increased energy requirements, a decline of thyroid hormone products, and an increase of serum TSH. We compared measurements in 12 subjects, before deployment (baseline), with 11 monthly studies during Antarctic residence (AR). After 4 months of AR (period 1), half of the subjects (T(4) group) received L-thyroxine [64 nmol.day(-)(1) (0.05 mg.day(-)(1))]; and the other half, a placebo (placebo group) for the next 7 months of AR (period 2). During period 1, there was a 12.3 +/- 5.1% (P < 0.03) decline on the matching-to-sample (M-t-S) cognitive task and an increase in depressive symptoms, compared with baseline. During the intervention in period 2, M-t-S scores for the T(4)-treated group returned to baseline values; whereas the placebo group, in contrast, showed a reduced M-t-S score (11.2 +/- 1.3%; P < 0.0003) and serum free T(4) (5.9 +/- 2.4%; P < 0.02), compared with baseline. The change in M-t-S score was correlated with the change in free T(4) (P < 0.0003) during both periods, and increases in serum TSH preceded worsening scores in depression, tension, anger, lack of vigor, and total mood disturbance (P < 0.001) during period 2. Additionally, the submaximal work rate for a fixed O(2) use decreased 22.5 +/- 4.9% in period 1 and remained below baseline in period 2 (25.2 +/- 2.3%; P < 0.005) for both groups. After 4 months of AR, the L-thyroxine supplement was associated with improved cognition, which seems related to circulating T(4). Submaximal exercise performance decrements, observed during AR, were not changed with this L-thyroxine dose. 相似文献
139.
J W Winslow A Shih J H Bourell G Weiss B Reed J T Stults L T Goldsmith 《Endocrinology》1992,130(5):2660-2668
Unlike that of other species, which have only one gene encoding relaxin, the human genome contains two nonallelic genes for relaxin, designated H1 and H2, which encode markedly different relaxin peptides. Whereas human relaxin gene H2 is selectively expressed in the ovary, no ovarian expression of gene H1 has been detected. Since relaxin is actively produced in the human male, it is possible to postulate divergent gene expression of relaxin in the male and female. We examined this question directly through the structural determination of human seminal relaxin and its comparison with the structure of human luteal relaxin. Partially purified relaxin, prepared from pooled human seminal plasma which had been delipidated by extraction with acid acetone and hexane, subjected to two cycles of HPLC and an additional purification step by ion-exchange chromatography, was further purified by immunoaffinity chromatography, using a monoclonal antibody to the H2 relaxin A chain which cross-reacts with synthetic H1 relaxin, followed by an additional HPLC step performed on a C4 reverse-phase column. The recovered, purified relaxin was then analyzed by N-terminal gas-phase sequencing and fast atom bombardment mass spectroscopy for determination of the amino acid sequence and molecular ions of the A and B chains, respectively. The results demonstrate that the structure of the predominant relaxin in human semen plasma is derived from the product of the H2 gene, consisting of a N-terminal pyroglutamic acid A-24 A chain and a mixture of B-26 and B-27 B chains. With the exception of degradation of the seminal relaxin B chain C-terminus, this structure is identical to the structure of human luteal relaxin. Therefore, both human seminal and luteal relaxin are products of the H2 gene. 相似文献
140.
An immunogenic 30-kDa surface antigen of pathogenic clinical isolates of Entamoeba histolytica 总被引:8,自引:0,他引:8
A 30-kDa surface antigen was identified by Western blots with human immune sera in all 15 isolates of E. histolytica from patients with invasive amebiasis (pathogenic) but not in 15 strains from asymptomatic patients (nonpathogenic). This antigen is highly immunogenic in naturally infected humans and was recognized by sera from 22 patients with invasive disease but not by sera from 13 patients harboring nonpathogenic strains. Its surface location is supported by its differential extraction in the detergent phase of Triton X-114 and by surface immunofluorescence of live trophozoites. Unlike previously described amebic surface antigens, this 30-kDa antigen is undetectable in axenic strains that were originally isolated from patients with invasive disease but have been adapted to grow without bacteria. Affinity-purified antibody to the 30-kDa antigen did not promote lysis of complement-resistant pathogenic strains. This surface antigen may be diagnostically important in the identification of pathogenic clinical isolates. 相似文献