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Allahwala Usaid K. Nour Daniel Alsanjari Osama Bhatia Kunwardeep Nagaraja Vinayak Khatri Jaikirshan J. Cockburn James Hildick-Smith David Sakata Yasuhiko Ward Michael Weaver James C. Bhindi Ravinay 《Journal of thrombosis and thrombolysis》2021,51(4):1005-1016
Journal of Thrombosis and Thrombolysis - Acute coronary collateralisation of an infarct-related arterial (IRA) territory may be identified during angiography for ST elevation myocardial infarction... 相似文献
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Tom Hsun-Wei Huang Kalpa De Silva Usaid K. Allahwala Edward J. Danson Pasi K. Karjalainen Olli A. Kajander Ravinay Bhindi 《Cardiovascular Revascularization Medicine》2019,20(1):16-21
Objective
This study aimed to assess the pathophysiological differences between saphenous vein grafts (SVG) and native coronary arteries (NCA) following presentation with non-ST elevated myocardial infarction (NSTEMI).Background
There is accelerated pathogenesis of de novo coronary disease in harvested SVG following coronary artery bypass (CABG) surgery, which contributes to both early and late graft failure, and is also causal in adverse outcomes following vein graft PCI. However in vivo assessment, with OCT imaging, comparing the differences between vein grafts and NCAs has not previously been performed.Methods
We performed a retrospective, observational, analysis in patients who underwent PCI with adjunctive OCT imaging following presentation with NSTEMI, where the infarct-related artery (IRA) was either in an SVG or NCA.Results
A total of 1550 OCT segments was analysed from thirty patients with a mean age of 66.3 (±9.0) years were included. The mean graft age of 13.9 (±5.6) years in the SVG group. OCT imaging showed that the SVG group had evidence of increased lipid pool burden (lipid pool quadrants, 2.1 vs 2.7; p?=?0.021), with a reduced fibro-atheroma cap-thickness in the SVG group (45.0?μm vs 38.5?μm; p?=?0.05) and increased burden of calcification (calcified lesion length?=?0.4?mm vs 1.8?mm; p?=?0.007; calcified quadrants?=?0.2 vs 0.9; p?=?0.001; arc of superficial calcium deposits?=?11.6° vs 50.9°; p?=?0.007) when compared to NCA.Conclusion
This OCT study has demonstrated that vein grafts have a uniquely atherogenic environment which leads to the development of calcified, lipogenic, thin-capped fibro-atheroma's, which may be pivotal in the increased, acute and chronic graft failure rate, and may underpin the increased adverse outcomes following vein graft PCI. 相似文献14.
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Comprehensive assessment of renal tumour complexity in a large percutaneous cryoablation cohort 
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Ross?J.?Mason Igor?Frank Bimal?Bhindi Matthew?K.?Tollefson R.?Houston?Thompson R.?Jeffrey?Karnes Robert?Tarrell Prabin?Thapa Stephen?A.?BoorjianEmail author 《World journal of urology》2017,35(12):1879-1884
Purpose
To evaluate perioperative and oncologic outcomes of patients undergoing radical cystectomy (RC) for recurrence of urothelial carcinoma (UC) after prior partial cystectomy (PC), and to compare these outcomes to patients undergoing primary RC.Methods
Patients who underwent RC for recurrence of UC after prior PC were matched 1:3 to patients undergoing primary RC based on age, pathologic stage, and decade of surgery. Perioperative and oncologic outcomes were compared using Wilcoxon sign-rank test, McNemars test, the Kaplan–Meier method, and Cox proportional hazards regression analyses.Results
Overall, the cohorts were well matched on clinical and pathological characteristics. No difference was noted in operative time (median 322 versus 303 min; p = 0.41), estimated blood loss (median 800 versus 700 cc, p = 0.10) or length of stay (median 9 versus 10 days; p = 0.09). Similarly, there were no differences in minor (51.7 versus 44.3%; p = 0.32) or major (10.3 versus 12.6%; p = 0.66) perioperative complications. Median follow-up after RC was 5.0 years (IQR 1.5, 13.1 years). Notably, CSS was significantly worse for patients who underwent RC after PC (10 year—46.8 versus 65.9%; p = 0.03). On multivariable analysis, prior PC remained independently associated with an increased risk of bladder cancer death (HR 2.28; 95% CI 1.17, 4.42).Conclusions
RC after PC is feasible, without significantly adverse perioperative outcomes compared to patients undergoing primary RC. However, the risk of death from bladder cancer may be higher, suggesting the need for careful patient counseling prior to PC and the consideration of such patients for adjuvant therapy after RC.18.
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Ross J. Mason Stephen A. Boorjian Bimal Bhindi Laureano Rangel Igor Frank R. Jeffrey Karnes Matthew K. Tollefson 《Clinical genitourinary cancer》2018,16(3):e629-e636