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排序方式: 共有394条查询结果,搜索用时 19 毫秒
11.
12.
Svetlana Kostić Ivan Tasić Dragan Mijalković Dragan Lović Dragan Djordjević Todorka Savić Nataša Miladinović Tasić Aleksandra Aranđelović 《Central European Journal of Medicine》2014,9(5):601-608
Abstract
Our aim was to establish the association of carotid intima-media thickness (CIMT) and ankle-brachial index(ABI) with the severity of coronary artery dissease (CAD). The study enrolled 150 examinees and divided them into two groups. The patients with stenotic changes in the coronary artery, constituted the first group (CP)(n=100); the second group consisted of the examinees without CAD — control goup (CG) (n=50). The following methods were used in the study: Color Doppler sonography of the carotid arteries, ABI, calculation of SCORE risk and coronary angiography.Results
The number of coronary blood vessels affected by atherosclerosis was significantly higher with the increase of CIMT, CV risk score, and waist-hip ratio by one measurement unit: CIMT by 0.729; p<0.05; CV risk score by 0.033; p<0.05; and waist-hip ratio by 3.182; p<0.01. With each increase of ABI value by one measurement unit, the number of involved blood vessels dropped by 0.844; p<0.05.Conclusions
Our results demonstrated that reduced ABI value, increased CIMT and number of plaques in the carotid arteries were in correlation with the severity of coronary artery disease. 相似文献13.
Validation of the prolapse quality of life questionnaire (P-QOL) in a Turkish population 总被引:2,自引:0,他引:2
Cam C Sakalli M Ay P Aran T Cam M Karateke A 《European journal of obstetrics, gynecology, and reproductive biology》2007,135(1):132-135
OBJECTIVE: To validate the Turkish translated version of the prolapse quality of life questionnaire (P-QOL). STUDY DESIGN: After establishing the test-retest reliability and internal consistency in a pilot study, 310 patients were enrolled in the study and general and subscale scores of the questionnaires were calculated. All participants underwent the International Continence Society (ICS) prolapse score (POP-Q). RESULTS: One hundred and forty-five (49.7%) women were symptomatic and 147 (50.3%) were asymptomatic. The level of missing data ranged from 0 to 2.2%. For the test-retest reliability, Spearman's rho was from 0.91 to 1.00 for all domains (p<0.001). The severity of P-QOL was strongly correlated with the vaginal examination findings among the symptomatic group (p<0.001). Items correlated with the objective vaginal examination findings. The total and domain scores for P-QOL of symptomatic and asymptomatic women were found to be statistically significant (p<0.001). CONCLUSION: The Turkish translated version of the P-QOL is reliable, consistent and valid instrument for assessing symptom severity, impact on quality of life in women with uterovaginal prolapse. It is easy to understand may be easily administered and self-completed by the women. 相似文献
14.
T Hayashida H Hiel D Dulon J P Erre A Guilhaume J M Aran 《Acta oto-laryngologica》1989,108(5-6):404-413
Regional selectivity of gentamicin (GM) ototoxicity was studied in guinea pigs (GPs) using electrophysiological, morphological, autoradiographic and immunohistological observations following combined treatment with GM (150 mg/kg i.m.) and ethacrynic acid (EA) (30 mg/kg i.c. or i.v., 1.5 h after GM injection). The GPs were either continuously stimulated every 5 min with a series of 256 clicks (70 dB peSPL, 10/s) during 3 h for monitoring fast changes in VIII nerve compound action potential (CAP) after the EA injection, and thereafter kept in the animal quarters (background noise of 60 dB SPL) (group I), or similarly monitored for only 10 min after the EA injection and thereafter kept in a soundproof room (around 0 dB SPL) (group II). Whenever GM labelling was observed it was localized only in the sensory hair cells. From 3 h after EA injection, the GPs in group I presented threshold elevations in the high-frequency region, which progressed to 60-80 dB at all frequencies at and after 48 h. Parallel to the threshold pattern, GM uptake in outer hair cells (OHCs) was seen with an increasing concentration from apex toward base from 3 to 24 h, while after 48 h almost all OHCs were destroyed and inner hair cells (IHCs) were marked by GM. In group II no changes in CAP thresholds were observed until more than 24 h, although GM was detected in the hair cells from 6 h on. At this early stage, the distribution of GM lacked a clear pattern, particularly without a clear apex-base gradient, and GM deposits were found only around the basal body. However in both groups, in late stage (greater than 24 h), the base-apex gradient was more pronounced and GM was found throughout the cell body, with a marked concentration below the cuticular plate. These results suggest that GM may penetrate hair cells around the basal body and that activating the cells by sound potentiates both GM uptake and its intracellular toxicity. 相似文献
15.
Development of the spiral ganglion in white rats was followed during the first 2 weeks after birth and morphological characteristics of the two neuronal types (I and II) were examined. In some neurons different stages of partial degeneration leading to formation of residual bodies were found without observation of degenerated cell, supporting the idea that differentiation at this time is not associated with cell death. Contacts between cell body of type II neurons and neuronal endings is reported for the first time. Such axo-somatic contacts previously observed only in monkey and man, also exists in lower mammals. 相似文献
16.
OBJECTIVE: The Global Assessment of Functioning (GAF) is an integral part of the standard multiaxial psychiatric diagnostic system. The purpose of including the GAF in DSM-IV as a tool for axis V assessment is to enable clinicians to obtain information about global functioning to supplement existing data about symptoms and diagnoses and to help predict the allocation and outcomes of mental health treatment. The purpose of this study was to examine the value of the GAF as part of a systemwide program for monitoring the allocation and outcomes of mental health care services. METHODS: Clinicians used the GAF to assess global functioning among 9,854 patients with psychiatric or substance use disorders, or both, who were already participating in an outcomes monitoring program of the Department of Veterans Affairs. A longitudinal prospective follow-up design was used. RESULTS: Patients' clinical diagnoses and symptoms were stronger predictors of GAF ratings than was their social or occupational functioning. GAF-rated impairment was associated with the provision of inpatient or residential care and outpatient psychiatric care, but patients with greater levels of impairment did not receive more treatment. GAF ratings were only minimally associated with treatment outcomes. No robust associations were found between GAF ratings and outcomes as assessed by clinician interview or by patients' self-report at follow-up. CONCLUSIONS: Including GAF ratings in a program for predicting the allocation and outcomes of mental health care is of questionable value. Research is needed to determine whether systematic training and ongoing validity checks would enhance the contribution of the GAF in monitoring service use and outcomes. 相似文献
17.
Comparison of clinical characteristics in good and poor insight obsessive-compulsive disorder 总被引:1,自引:0,他引:1
Beginning with DSM-III-R, the condition of an intact insight towards obsessive-compulsive symptoms, which was essential for the classical definition of obsessivecompulsive neurosis, has been removed, permitting inclusion of cases with poor insight. A total of 94 cases who met DSM-III-R criteria for obsessive-compulsive disorder were included in this study. The Structured Clinical Interview for DSM-III-R (SCID-P), YaleBrown Obsessive Compulsive Scale (Y-BOCS), Hamilton Rating Scale for Depression (HRSD), Hamilton Rating Scale for Anxiety (HRSA), and State-Trait Anxiety Inventory (STAI) were administered to each patient. Two subgroups determined by DSM-IV item "poor insight" were compared for demographic variables and the scores obtained on the scales. Scores on the Y-BOCS, HRSA, HRSD and STAI-state were significantly higher in the poor insight group. Current and past major depression were also more frequent. Among personality disorders (PDs), avoidant PD was more common in the good insight group and borderline and narcissistic PDs were more common in the poor insight group. HRSA, HRSD, and STAI-state scores had weak to moderate but significant correlations with insight as defined by the item 11 of Y-BOCS. Findings are discussed in view of previous reports. 相似文献
18.
Darrouzet V Erre JP Dulon D Camicas Van Gout M Aran JM Poutout PA Négrevergne M Dauman R Bébéar JP 《Revue de laryngologie - otologie - rhinologie》1999,120(5):305-316
OBJECTIVES: To establish that susceptance-conductance tympanograms at a probe-tone frequency of 2 kHz reflects the status of the annular ligament (AL) and through it of the cochlea. METHODS: Experimental study in 5 chinchillas and 22 guinea pigs. Six validating experiments were used: blockages of the stapes and of the round window membrane (RWM), fistula of the RWM, fluid removal from the cochlea, injection of saline in the scala tympani (ST) and acoustic trauma (AT). Quantitative data (mean values of Y226, FR, Y2000, G2000 and B2000) and shape of the curves were analyzed before and immediately after lesions were done. RESULTS: Guinea pig was the most convenient provided bulla was vented and the same tip was used along the experiments. Only the shape of the curves are discriminant: 1/a supplementary sharp peak, centered around negative pressures, is observed in Y/G tympanograms in every case of RWM fistulas and in some case of AT. 2/injection of saline into ST induces immediate and reproducible Y2000, G2000, et B2000 curves modifications. 3/RWM and stapes blockages provoke foreseeable stiffening and sharpening of the tympanograms at 2 kHz. 4/on the contrary, fluid removal from the cochlea induces multiple peaks curves. CONCLUSIONS: Experimentally-induced modifications at the AL either direct (stapes blockage) or indirect by AT or decrease/increase of pressure load at the cochlear interface at the footplate result in noticeable, constant, reproducible changes of curves registered at 2 kHz. The stapes behaves both as the plotter of the curves and the interpreter of the inner ear pressure. 相似文献
19.
Attenuation of aminoglycoside-induced cochlear damage with the metabolic antioxidant alpha-lipoic acid 总被引:3,自引:0,他引:3
Free radical generation is increasingly implicated in a variety of pathological processes, including drug toxicity. Recently, a number of studies have demonstrated the ability of gentamicin to facilitate the generation of radical species both in vivo and in vitro, which suggests that this process plays an important role in aminoglycoside-induced ototoxicity. Free radical scavengers are compounds capable of inactivating free radicals, thereby attenuating their tissue damaging capacity. In this study we have determined the ability of the powerful free radical scavenger alpha-lipoic acid (100 mg/kg/day) to attenuate the cochlear damage induced by a highly ototoxic regimen of the aminoglycoside amikacin (450 mg/kg/day, i.m.). Experiments were carried out on pigmented guinea pigs initially weighing 200-250 g. Changes in cochlear function were characterized as shifts in compound action potential (CAP) thresholds, estimated every 5 days, by use of chronic indwelling electrodes implanted at the round window, vertex, and contralateral mastoid. Results showed that animals receiving alpha-lipoic acid in combination with amikacin demonstrated a significantly less severe elevation in CAP thresholds compared with animals receiving amikacin alone (P < 0.001; t-test). These results provide further evidence of the recently reported intrinsic role of free radical generation in aminoglycoside ototoxicity, and highlight a potential clinical therapeutic use of alpha-lipoic acid in the management of patients undergoing aminoglycoside treatment. 相似文献
20.
Summary
Background
To investigate
dietary habits and evaluate
these with regard to cardiovascular
risk status in Turkish adolescents
aged 12–19 years.
Methods
A total
of 300 adolescents, 135 males and
165 females aged between 12 and
19, were included in the study. Dietary
intake was determined by using
3–day food records (including 1
weekend day). Adolescents smoking
habits and familial chronic diseases
were recorded. The values obtained
for energy and nutrient
intakes were compared with RDA
and DRI and recommendations
given by AHA.
Results
The mean
energy intakes of male and female
subjects were 1964 ± 723 kcal and
1804 ± 486 kcal respectively. According
to NHANES III, age–standardized (CDC: Centers for Disease
Control and Prevention) prevalence
of overweight indicated that
20.7% among male and 17.5%
among female adolescents were at
risk for becoming overweight. The
prevalence of premature CHD family
history was found to be 9.6%
for males and 11.5 % for females.
The prevalence of current smoking
was found to be 22.2 % for males
and 18.2 % for females. In addition,
29.6% of the males and 37.6% of
the females were physically inactive
(p < 0.05); however, male adolescents
(48.2%) were significantly
more likely than female adolescents
(52.1 %) to report sufficient
moderate physical activity
(p < 0.05). The dietary fiber intake
was slightly below the recommended
intake of 10 g per 1000
kcal. Compared to the AHA averages,
these adolescents had significantly
higher intake of total fat, saturated
fat, sodium and dietary
cholesterol and lower intake of
polyunsaturated fat, monounsaturated
fat and dietary fiber. The
Turkish adolescents also had
higher amounts of energy from fat.
The mean percentage of energy
from fat was 34.2 ± 6% TE for
males and 35.2 ± 6.8 % TE for females;
saturated fat was
11.8 ± 6.8 % TE for males and
12.1 ± 8.9 for females. The intake of
fat and saturated fat was higher
than the AHA recommendations.
The polyunsaturated to saturated
fat ratio was 0.4 ± 0.2 and reflected
a high saturated fat (12.0 ± 7.7%
TE) and low polyunsaturated fat
(5.5 ± 3.9 % TE) diet. In addition,
the percentage of adolescents who
did not meet 66% of RDA for vitamin
E, B6, and folates and the recommendation
for RDA dietary
fiber is presented. Approximately,
80% of adolescents failed to meet
the dietary recommendation of the
AHA for polyunsaturated fatty
acids, and about 26.7% reported a
cholesterol intake higher than
100 mg/1000 kcal.
Conclusion
It can
be said that fiber, total fat, saturated
fatty acid, cholesterol and
sodium intake of Turkish adolescents
are found to be high; however,
their vitamin E, vitamin B6
and folate intake are found to be
low compared to AHA recommendations.
Turkish adolescents fruit
and vegetable intake are also found
to be low. 相似文献