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81.
L Delgove J Lebeau Y Le Bescond B Rapha?l 《Annales de chirurgie plastique et esthétique》1991,36(2):95-100
Certain failures in scalp surgery due to defective venous drainage have led the authors to reconsider the classical anatomical data concerning the temporofrontal venous network. The study conducted in the anatomy laboratory concerned 110 superficial temporal territories injected with various coloured polymerizable substances in order to visualize this network in the skin. This study enabled the authors to describe nine types of venous drainage, the surgical implications of which are discussed. 相似文献
82.
Thomas Viel Bertrand Kuhnast Françoise Hinnen Raphaël Boisgard Bertrand Tavitian Frédéric Dollé 《Journal of labelled compounds & radiopharmaceuticals》2007,50(13):1159-1168
Small interfering RNAs (siRNAs), a class of macromolecules constituted by the association of two single‐stranded ribonucleic acids of short sequences, have been labelled with the positron‐emitter fluorine‐18 (T1/2: 109.8 min). The strategy involves (1) prosthetic conjugation of a single‐stranded oligonucleotide with [18F]FPyBrA (N‐[3‐(2‐[18F]fluoropyridin‐3‐yloxy)‐propyl]‐2‐bromoacetamide) followed by (2) formation of the target duplex by annealing with the complementary sequence, therefore, permitting parallel and combinatorial preparation of [18F]siRNAs. Pure fluorine‐18‐labelled siRNAs (0.55–1.11 GBq, specific activity: 74–148 GBq/µmol at EOB) could be obtained within 165 min starting from 37.0 GBq of starting [18F]fluoride (1.5–3.0%, non‐decay‐corrected isolated yields). Copyright © 2007 John Wiley & Sons, Ltd. 相似文献
83.
84.
Yvan L’Homme Rapha?l Sansregret étienne Plante-Fortier Anne-Marie Lamontagne Mourad Ouardani Geneviève Lacroix Carole Simard 《Virus genes》2009,39(1):66-75
This study reports the molecular characterization of novel caliciviruses, the St-Valérien-like viruses, which were isolated
from pig feces in the province of Quebec, Canada between 2005 and 2007. The genomes of St-Valérien-like viruses contain 6409
nucleotides and include two main open reading frames (ORFs). ORF1 encodes the non structural (NS) polyprotein and the major
capsid protein (VP1) while ORF2 encodes the putative basic minor capsid protein. Typical conserved amino acid motifs predict
a gene order reminiscent of calicivirus genomes. Phylogenetic, pairwise homology, and distance analyses performed on complete
genomic sequences and partial amino acid sequences from the NTPase, polymerase, and major capsid protein segregated the St-Valérien-like
viruses in a unique cluster sharing a common root with the Tulane virus and the noroviruses. Based on the genomic analyses
presented, the St-Valérien-like viruses are members of a new genus of Caliciviridae for which we propose the name Valovirus. 相似文献
85.
Mathilde Raphaël Marie-Cécile le Deley Gilles Vassal Xavier Paoletti 《European journal of cancer (Oxford, England : 1990)》2010,46(8):1392-1398
PurposeThe European medicines agency (EMEA) has stated that the degree of pre-treatment could modify the patient’s tolerance to new treatments in paediatric oncology. It is current practice to divide a phase I trial into two groups to identify the maximum tolerated dose (MTD) in each group separately. The aim of this study was to investigate the relevance of this approach.MethodsWe reanalysed a large phase I trial of Irinotecan that included 80 children (32 heavily pretreated patients and 48 less heavily pretreated). An extended simulation study was performed to investigate the robustness of the conclusions in the context of small sample sizes. Dose recommendations were studied according to scenarios with group differences, as measured by odds ratio (OR), ranging from 1 (no difference) to 10 (large difference) and sample sizes increasing from 20 × 2 to 60 × 2 patients.ResultsThis study shows a high risk of misidentification of the MTD in each of the two groups, regardless of the group difference. With a group difference corresponding to OR = 8 and balanced sample sizes (20 × 2 patients), the same MTD was identified in 11% of the simulations. Even with larger sample sizes (40 × 2 patients), this figure reached 24% for OR = 3. There is also a very high risk of identifying two different MTD (52% for 40 × 2 patients) although the risk is similar in both groups.ConclusionsTwo independent sample designs in paediatric phase I trials should be avoided or reserved to limited situations when there is a strong rationale possibly based on adult data. 相似文献
86.
Clinical Orthopaedics and Related Research® - 相似文献
87.
Laurent Mathieu Raphaël Vialle Camille Thevenin-Lemoine Pierre Mary Jean-Paul Damsin 《Journal of children's orthopaedics》2008,2(6):449-455
Purpose Many surgical techniques have been published on how to treat congenital pseudoarthrosis of the tibia (CPT). We combined Ilizarov’s
fixator with intramedullary nailing of the tibia and developed a procedure which combines the advantages of both methods:
Ilizarov’s high fusion rate with alignment control and the protection against refracture provided by the intramedullary nail.
The results of this approach are presented and discussed.
Material and methods Seven boys and three girls aged 3–14 years (mean age 8 years 2 months) were treated using our combined technique. In six cases,
the CPT was associated with neurofibromatosis. Two strategies were adopted: in six cases, a compression was applied on the
bone defect, and in four cases, segmental bone transportation was performed before the compression procedure. The final follow-up
(1.2–6.6 years) included a clinical and radiological examination.
Results Tibial union was achieved in nine cases without bone grafting. In one case, tibial union still remains uncertain, despite
intertibiofibular bone grafting and additional compression procedures. Thirteen overall complications were noted, including
three valgus deformity of the ankle. Bone transportation failed to achieve complete limb lengthening in three cases. One deep
infection occurred 4 years after removal of the external fixator. The treatment for this included nail removal and antibiotic
therapy for 3 months. Despite a permanent protection of orthosis, a refracture occurred 2 years after nail removal, reverting
to the initial level of pseudarthrosis. Another surgical attempt using the same method was then performed with a satisfactory
result.
Conclusions The association of Ilizarov’s technique and intramedullary nailing achieved and maintained tibial union in nine of ten patients
at final follow-up. It also allowed correction of axial deformities and prevented refracture. Despite the short duration of
the follow-up and a high rate of complications in our series, this method can be useful in many cases of CPT in which healing
has failed to occur despite many previous surgeries. 相似文献
88.
Pascal Delamillieure Dominique Ochoa-Torres Thierry Vasse Perrine Brazo Rapha?l Gourevitch Sophie Langlois Fran?oise Assouly-Besse Alexis Van Der Elst Rémy Morello Julien Guelfi Michel Petit Sonia Dollfus 《European psychiatry》2005,20(4):346-348
We assessed the subjective quality of life (QOL) of 30 deficit schizophrenic patients compared to 112 nondeficit schizophrenic patients. The deficit patients did not differ in term of QOL, total score of positive symptoms, general psychopathology from the nondeficit patients. This result suggested an absence of impact of primary negative symptoms on the subjective QOL in schizophrenic patients. 相似文献
89.
Survival of elderly patients on peritoneal dialysis: retrospective study of 292 patients, from 1982 to 1999. 总被引:3,自引:0,他引:3
Fran?ois Vrtovsnik Rapha?l Porcher Catherine Michel Gilles Hufnagel Guillaume Queffeulou France Mentré Fran?oise Mignon 《Peritoneal dialysis international》2002,22(1):73-81
BACKGROUND: Dialysis is becoming increasingly frequent in patients over 75 years of age. Age is a superimposed comorbid factor commonly associated with poor prognosis in these patients. OBJECTIVE: To analyze the survival of 292 patients aged over 75 years on initiation of peritoneal dialysis (PD) from September 1982 to September 1999. DESIGN: Retrospective study. SETTING: Nephrology department in a University Hospital. RESULTS: Mean age was 81.5 years (range 75-92 years); 178 patients were over 80 years and 60 patients were over 85 years. Sex ratio was 136F/156M. Ninety-day mortality rate was 12%. Excluding the first 3 months, median patient survival was 21.6 months; 226 patients died on PD and 24 were shifted to hemodialysis. Survival was inversely correlated with the Charlson combined comorbidity index (CCI), but independent of predialysis hemoglobin and serum albumin levels. Over three selected periods, 1982-1989, 1989-1995, and 1995-1999, an increase was found in mean age (79.7 +/- 3.3, 82.6 +/- 3.9, and 81.8 +/- 4.4 years; p < 0.001), CCI (7.6 +/- 1.59, 8.0 +/- 1.52, and 8.5 +/- 1.63; p = 0.01), and predialysis creatinine clearance (6.2 +/- 2.3, 6.4 +/- 2.4, and 9.8 +/- 3.8 mL/minute; p < 0.001). Median survival was similar in the various selected periods (21.0, 21.5, and 25.4 months). The incidence of peritonitis decreased from 0.63 to 0.21 episodes per patient year. CONCLUSION: From 1982 to 1999, mean age and comorbidity increased on initiation of dialysis in elderly patients, with no increase in mortality. Survival in elderly patients on PD was related to the age-comorbidity index. 相似文献
90.
Santillana-Hayat M Sarfati C Fournier S Chau F Porcher R Molina JM Derouin F 《Antimicrobial agents and chemotherapy》2002,46(6):2049-2051
We combined tissue culture and flow cytometry to assess the activities of various temperatures, chemicals, and disinfectants on the viability and infectivity of spores of Encephalitozoon intestinalis. Surfanios and benzalkonium chloride, disinfectants currently used in the hospital, were remarkably efficient in destroying spore viability and infectivity. 相似文献