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ECG‐gated pulmonary artery CTA for evaluation of right ventricular function in patients with acute pulmonary embolism
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The evaluation of gastrointestinal function in diabetic patients 总被引:2,自引:0,他引:2
Quigley EM 《World journal of gastroenterology : WJG》1999,5(4):13-282
Nowadays,anumberofoptionsareavailablefortheasesmentofgastricmotorfunction.Thus,aglobalevaluationofgastricmotorfunctionmaybeob... 相似文献
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Endocarditis in the drug addict 总被引:4,自引:0,他引:4
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Safety of aerosolized INS 365 in patients with mild to moderate cystic fibrosis: results of a phase I multi-center study 总被引:1,自引:0,他引:1
Noone PG Hamblett N Accurso F Aitken ML Boyle M Dovey M Gibson R Johnson C Kellerman D Konstan MW Milgram L Mundahl J Retsch-Bogort G Rodman D Williams-Warren J Wilmott RW Zeitlin P Ramsey B;Cystic Fibrosis Therapeutics Development Research Group 《Pediatric pulmonology》2001,32(2):122-128
Cystic fibrosis (CF) is characterized by defective cystic fibrosis transmembrane regulator (CFTR) expression and function, associated with abnormal ion transport and mucociliary clearance, and clinical lung disease. Triphosphate nucleotides such as uridine-5'-triphosphate (UTP) and INS 365, may be useful for CF through actions, mediated via P2Y(2) extracellular receptors, on chloride and liquid secretion, and ciliary beat frequency. INS 365 may offer chemical stability advantages over UTP. In a randomized, double-blind, multicenter phase I study, we studied the safety and maximally tolerated dose of escalating, single doses of aerosolized INS 365, in adult and pediatric patients with mild to moderate CF lung disease (FEV(1) > or = 45% predicted). In four successive dose cohorts of adult patients (n = 12 per cohort, age > or = 18 years) and four successive pediatric dose cohorts (n = 12 per cohort, age 5-12 years), patients were randomized 3:1 active/placebo (0.9% saline) to evaluate doses of 20, 40, 80, and 100 mg INS 365 delivered by nebulizer (Pari Star ). Sputum was collected pre- and post-dosing to obtain preliminary results on clinical efficacy. After each dose cohort, a Data Safety Monitoring Committee (DSMC) reviewed the data. Forty-eight adult and 36 pediatric patients completed the protocol (up to 100 mg for adults, 80 mg for pediatric patients). The predominant adverse events were cough, wheezing, chest tightness, and a decrease in FEV(1) (occurring in 8/48 adults, and 5/36 pediatric patients), which occurred predominantly in the 80-mg and 100-mg dose cohorts. Though a few adult patients had a tendency to increase sputum production, there was little consistent effect noted on sputum production in this acute, single-dose study. The data suggest that aerosolized INS 365 is safe when delivered at single doses of up to 40 mg in adults and children with CF, but that higher doses are unlikely to be tolerated. 相似文献
80.
Research Review: Neuropsychological test performance in pediatric obsessive–compulsive disorder – a meta‐analysis
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