全文获取类型
收费全文 | 4416篇 |
免费 | 195篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 81篇 |
儿科学 | 398篇 |
妇产科学 | 129篇 |
基础医学 | 362篇 |
口腔科学 | 49篇 |
临床医学 | 282篇 |
内科学 | 1056篇 |
皮肤病学 | 39篇 |
神经病学 | 197篇 |
特种医学 | 296篇 |
外科学 | 692篇 |
综合类 | 65篇 |
一般理论 | 4篇 |
预防医学 | 115篇 |
眼科学 | 55篇 |
药学 | 314篇 |
中国医学 | 27篇 |
肿瘤学 | 465篇 |
出版年
2024年 | 2篇 |
2023年 | 32篇 |
2022年 | 64篇 |
2021年 | 150篇 |
2020年 | 73篇 |
2019年 | 116篇 |
2018年 | 144篇 |
2017年 | 108篇 |
2016年 | 130篇 |
2015年 | 145篇 |
2014年 | 181篇 |
2013年 | 258篇 |
2012年 | 359篇 |
2011年 | 428篇 |
2010年 | 252篇 |
2009年 | 233篇 |
2008年 | 287篇 |
2007年 | 286篇 |
2006年 | 280篇 |
2005年 | 268篇 |
2004年 | 236篇 |
2003年 | 168篇 |
2002年 | 171篇 |
2001年 | 15篇 |
2000年 | 23篇 |
1999年 | 17篇 |
1998年 | 31篇 |
1997年 | 36篇 |
1996年 | 30篇 |
1995年 | 12篇 |
1994年 | 13篇 |
1993年 | 13篇 |
1992年 | 8篇 |
1991年 | 6篇 |
1990年 | 10篇 |
1989年 | 4篇 |
1988年 | 5篇 |
1987年 | 3篇 |
1986年 | 2篇 |
1985年 | 3篇 |
1984年 | 4篇 |
1982年 | 1篇 |
1981年 | 8篇 |
1980年 | 3篇 |
1979年 | 3篇 |
1978年 | 1篇 |
1976年 | 2篇 |
1972年 | 1篇 |
1971年 | 1篇 |
排序方式: 共有4626条查询结果,搜索用时 31 毫秒
51.
52.
53.
Roop Singh Raghubir Singh Rajesh K Rohilla Narender K Magu Rakesh Goel Kiranpreet Kaur 《International wound journal》2013,10(4):455-460
The recurrence of pressure ulcers (PrUs) and dehiscence of reconstructive flap have always been a problem. The present study aimed to evaluate the results of reconstructive flap surgeries in patients with spinal cord injury (SCI) having PrUs, using classic and modified flaps with improvisations to decrease wound dehiscence, flap necrosis and tension in flap. This is a prospective clinical study. The setting was a tertiary care centre in northern India. Thirty‐five patients with SCI having 37 stage III and IV PrUs. PrUs were treated using classic and modified flaps with improvisations. The outcome was evaluated using criteria of wound dehiscence, flap necrosis and recurrence. The results of flap surgery were excellent in 32 (86·48%) patients, good in 4 (10·81%) patients and poor in 1 (2·7%) patient. Partial flap necrosis (2·7%), low incidence of PrU recurrence rate at flap site (5·4%) and overall PrU recurrence (11·4%) were the complications observed. Improvisation of classic and modified techniques of flap surgeries along with reinforcement of general care principles of paraplegia can be effective in minimising complications often associated with PrU reconstructive surgery thus improving the ultimate outcome. 相似文献
54.
Amit Goel Dharmendra Singh Bhadauria Anupma Kaul Narayan Prasad Amit Gupta Raj Kumar Sharma Praveer Rai Rakesh Aggarwal 《Indian journal of gastroenterology》2017,36(2):137-140
In recent past, direct-acting anti-viral drugs (DAAs) have become the standard of care for the treatment of hepatitis C virus (HCV) infection. However, the experience with the use of these drugs in Indian renal transplant recipients is limited. We retrospectively reviewed our experience with DAA-based treatment for HCV infection in such patients. Between April 2015 and December 2016, six adults (median age 41 [range 34–52] years, male 5; GT1 2, GT3 3, and GT4 1; including three with prior failed interferon-based treatment) had received genotype-guided, DAA-based anti-HCV treatment 1 to 158 (median 15) months after renal transplantation. Of them, four completed the planned 24-week treatment without any significant adverse event. One of them had increase in serum creatinine after 16 weeks of treatment with sofosbuvir and daclatasvir, with acute interstitial nephritis on kidney biopsy; his renal function improved on stopping the drugs. The other patient had preexisting mild renal dysfunction, which worsened after 8 weeks of sofosbuvir-ledipasvir treatment; this did not reverse on stopping treatment. All the six patients achieved undetectable HCV RNA after 4 weeks of treatment and also achieved sustained virologic response, i.e. lack of detectable HCV RNA in serum 12 weeks after stopping treatment. Overall, DAA-based treatment was effective in treating HCV infection in our renal transplant recipients; however, caution and monitoring of renal function during such treatment is advisable in patients who have additional factors that predispose to renal injury. 相似文献
55.
56.
57.
58.
Mohane Selvaraj Coumar Fang-Ying Tsai Jagat Rakesh Kanwar Sailu Sarvagalla Chun Hei Antonio Cheung 《Cancer treatment reviews》2013
Since the discovery of survivin (BIRC5) as a cancer-related molecule by Grazia Ambrosini and Dario C. Altieri at 1997, our knowledge related to the function of this molecule has been extended from simple apoptosis inhibition to complicated, interlinked processes that involve interference of mitosis, apoptosis, autophagy, and even DNA repair recently. However, despite the growing amount of knowledge related to survivin in the last ten years, the development of survivin inhibitors or survivin-related molecular therapies is surprisingly and relatively slow as compared to other therapeutic inhibitors for cancer treatment. Here, the molecular functions of survivin and the progress of development of survivin-targeting therapies are discussed in detail. Functional differences between different survivin-specific inhibitors are discussed from both structural and biochemical point of views. This review also reveals different challenges that scientists are currently facing in the development of survivin inhibitors for clinical application. Finally, future directions for the development of survivin-targeted therapies are discussed in this review. 相似文献
59.
Increasingly pre-hospital trauma management involves transfer of patients using a scoop stretcher; a number of computed tomography (CT) compatible scoops have recently appeared on the market. We sought to evaluate any differences in image quality in polytrauma patients scanned in a scoop stretcher. CT studies of 234 consecutive patients presenting between December 2011 and August 2012 at our regional level 1 tertiary trauma centre were retrospectively reviewed. Patients were allocated into two groups: those scanned with a scoop stretcher and without. CTs were reviewed by a consultant radiologist and two senior radiology trainees and graded separately for quality/artefact. A scale of 1–5 was employed: 1—uninterpretable, 2—borderline image quality, 3—acceptable, 4—good, 5—excellent. A total of 128 (54.7 %) patients were scanned in a scoop stretcher and 106 (45.3 %) were scanned without, 183 males and 51 females (average age, 46 (16–94)?years; SD, 20). The average quality grading for the patients scanned in the scoop was 4.64 compared to 4.68 in those without the scoop. There was no significant grading difference between the groups, consultant (p?=?0.096) and trainees (p?=?0.782). No artefacts were attributable to the scoop stretcher 0/128 (0 %). Following our experience, the use of scoop stretchers is recommended for efficient, safe and practical management of trauma patients and in terms of imaging, with no detrimental effect on image quality. 相似文献
60.
Yogendra Pratap Singh Rakesh Bhaskar 《Journal of biomaterials science. Polymer edition》2013,24(18):1756-1778
AbstractGelatin, chitosan and nano calcium phosphate based composite scaffold with tailored architectures and properties has great potential for bone regeneration. Herein, we aimed to improve the physico chemical, mechanical and osteogenic properties of 3D porous scaffold by incorporation of dihydrogen calcium phosphate anhydrous (DCPA) nanoparticles into biopolymer matrix with variation in composition in the prepared scaffolds. Scaffolds were prepared from the slurry containing gelatin, chitosan and synthesized nano DCPA particle using lyophilization technique. DCPA nano particles were synthesized using calcium carbonate and phosphoric acid in water–ethanol medium. XRD pattern showed phase pure DCPA in synthesized nanopowder. Scaffolds were prepared by addition of DCPA nanoparticles to the extent of 5–10?wt% of total polymer into gelatin–chitosan solution with solid loading varying between 2.5 and 2.75?wt%. The prepared scaffold showed interconnected porosity with pore size varying between 110 and 200 micrometer. With addition of DCPA nanoparticles, average pore size of the prepared scaffolds decreased. With increase in nano ceramic phase content from 5?wt% to 10?wt% of total polymer, the compressive strength of the scaffold increased. Scaffold containing 10?wt% DCPA showed the highest average compressive strength of 2.2?MPa. Higher cellular activities were observed in DCPA containing scaffolds as compared to pure gelatin chitosan scaffold suggesting the fact that nano DCPA addition into the scaffold promoted better osteoblast adhesion and proliferation as evident from MTT assay and scanning electron microscopic (SEM) investigation of osteoblast cultured scaffolds. A higher degree of lamellopodia and filopodia extensions and better spreading behavior of osteoblasts were observed in FESEM micrographs of MG 63 cultured DCPA containing scaffold. The results demonstrated that both mechanical strength and osteogenic properties of gelatin–chitosan scaffold could be improved by addition of anhydrous dihydrogen calcium phosphate nanoparticles into it. 相似文献