全文获取类型
收费全文 | 2578篇 |
免费 | 131篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 208篇 |
妇产科学 | 87篇 |
基础医学 | 237篇 |
口腔科学 | 53篇 |
临床医学 | 162篇 |
内科学 | 550篇 |
皮肤病学 | 33篇 |
神经病学 | 189篇 |
特种医学 | 77篇 |
外科学 | 456篇 |
综合类 | 90篇 |
预防医学 | 62篇 |
眼科学 | 109篇 |
药学 | 196篇 |
中国医学 | 14篇 |
肿瘤学 | 175篇 |
出版年
2022年 | 32篇 |
2021年 | 62篇 |
2020年 | 26篇 |
2019年 | 48篇 |
2018年 | 72篇 |
2017年 | 36篇 |
2016年 | 56篇 |
2015年 | 56篇 |
2014年 | 88篇 |
2013年 | 106篇 |
2012年 | 138篇 |
2011年 | 188篇 |
2010年 | 112篇 |
2009年 | 96篇 |
2008年 | 164篇 |
2007年 | 141篇 |
2006年 | 159篇 |
2005年 | 109篇 |
2004年 | 106篇 |
2003年 | 96篇 |
2002年 | 81篇 |
2001年 | 51篇 |
2000年 | 63篇 |
1999年 | 55篇 |
1998年 | 16篇 |
1997年 | 18篇 |
1996年 | 14篇 |
1995年 | 19篇 |
1994年 | 16篇 |
1992年 | 34篇 |
1991年 | 19篇 |
1990年 | 29篇 |
1989年 | 36篇 |
1988年 | 32篇 |
1987年 | 38篇 |
1986年 | 23篇 |
1985年 | 29篇 |
1984年 | 13篇 |
1983年 | 20篇 |
1982年 | 14篇 |
1980年 | 13篇 |
1979年 | 11篇 |
1978年 | 8篇 |
1977年 | 13篇 |
1976年 | 9篇 |
1975年 | 14篇 |
1974年 | 30篇 |
1973年 | 17篇 |
1972年 | 17篇 |
1971年 | 17篇 |
排序方式: 共有2716条查询结果,搜索用时 0 毫秒
21.
Mice receiving a first treatment with graded doses of various heavy charged particles (protons and heavy ions) to one of their hind legs were re-exposed to a fixed dose of x rays eight months later to study the "memory" of residual damage from the first treatment. No significant memory of the first radiation exposure was observed for acute skin rection. However, there is an indication of memory for foot deformity. The results do not seem to indicate any significant differences in memory after exposure to 60Co gamma rays compared with protons or heavy ions, if biological effectiveness of the doses is taken into consideration. 相似文献
22.
23.
Christopher R Gibson Charles Lin Rominder Singh Cheri M Brown Karen Richards Janice Brunner Kimberly Michel Jennifer Adelsberger Edward Carlini Catherine Boothe-Genthe Conrad Raab Minh Luu Aimee Michael Mona Parikh Patrice Ciecko Raju Subramanian Paul Krolikowski A David Rodrigues Thomas A Baillie Thomas H Rushmore 《Drug metabolism and disposition》2005,33(7):1044-1051
Compound I [3-[5-(4-methanesulfonyl-piperazin-1-ylmethyl)-1H-indol-2-yl]-1H-quinolin-2-one] is a potent inhibitor of human kinase insert domain-containing receptor (KDR kinase), which is under investigation for the treatment of cancer. Bile duct-cannulated male beagle dogs were administered 6 mg/kg compound I q.d. for 14 days. There was an approximately 2.5-fold decrease in the mean plasma area under the curve of I on days 7 and 14 (approximately 11.3 microM . h), relative to day 1 (28.2 microM . h). In the dog, compound I was eliminated by metabolism, with a major pathway being aromatic hydroxylation and subsequent sulfation to form the metabolite M3. Metabolic profiling suggested that the pathway leading to the formation of the sulfated conjugate M3 was induced upon multiple dosing of I. Studies conducted in vitro suggested that CYP1A1/2 was responsible for the formation of the hydroxylated metabolite, which is sulfated to yield M3. Additional studies confirmed induction of CYP1A protein and activity in the livers of dogs treated with I. However, studies in a dog hepatocyte model of induction showed a surprising decrease both in CYP1A mRNA and enzymatic activity in the presence of I, emphasizing the need to consider the results from a variety of in vitro and in vivo studies in deriving an understanding of the metabolic fate of a drug candidate. It is concluded that the autoinduction observed after multiple treatments with compound I occurs since compound I is both an inducer and a substrate for dog CYP1A. 相似文献
24.
25.
Mahesh Chandra Hedge Panduranga M. Kamath Suja Shreedharan Naveen Kumar Dannana Ravikumar M. Raju 《Indian journal of otolaryngology and head and neck surgery》2006,58(1):31-34
The efficacy of supravital staining in the detection of malignancies in oro and oropharyngeal lesions and its role in the
detection of malignant changes in premalignant lesions were studied. This prospective study comprises 90 cases of clinically
suspicious lesions and it was done over a period of 3 years. Most of the patients had multiple risk factors for the development
of malignancy. All underwent staining with a modified solution of 1% toluidine blue (TB). In our study the overall sensitivity
was 97.29% and the specificity was 62.5%. 相似文献
26.
Lantana camara is used in herbal medicine for the treatment of skin itches, as an antiseptic for wounds, and externally for leprosy and scabies. The objective of our study was to investigate excision wound healing activity of the leaf extract of L. camara in rats. The animals were divided into two groups of 12 each in both the models. The test group animals were treated with the aqueous extract of L. camara (100 mg/kg/day) topically and the control group animals were left untreated. Wound healing efficacy was measured by determining the morphological and biochemical parameters. Wound healing time, wound contraction and synthesis of collagen were monitored periodically. Antimicrobial activities of the extract against the microorganisms were also assessed. Treatment of the wounds with extract enhanced significantly the rate of wound contraction (98%), synthesis of collagen and decreased mean wound healing time. These studies demonstrate that L. camara is effective in healing excision wounds in the experimental animal and could be evaluated as a therapeutic agent in tissue repair processes associated with skin injuries. 相似文献
27.
Potentiation of tumor response to radiation or chemoradiation by selective cyclooxygenase-2 enzyme inhibitors 总被引:15,自引:0,他引:15
Nakata E Mason KA Hunter N Husain A Raju U Liao Z Ang KK Milas L 《International journal of radiation oncology, biology, physics》2004,58(2):369-375
Cyclooxygenase-2 (COX-2) is an enzyme expressed primarily in pathologic states, such as inflammatory disorders and cancer, where it mediates prostaglandin production. Its overexpression is associated with more aggressive biologic tumor behavior and adverse patient outcome. Increasing evidence shows that agents that selectively inhibit COX-2 enhance tumor response to radiation or chemotherapeutic agents. This article gives an overview of some of this evidence. In addition, we describe new results showing that celecoxib, a selective COX-2 inhibitor, enhanced response of A431 human tumor xenografts in nude mice to radiation by an enhancement factor (EF) of 1.43 and to the chemotherapeutic agent docetaxel by an EF of 2.07. Celecoxib also enhanced tumor response when added to the combined docetaxel plus radiation treatment (EF = 2.13). Further experiments showed that selective COX-2 inhibitors enhanced tumor cell sensitivity to ionizing radiation, involving inhibition of cellular repair from radiation damage and cell cycle redistribution as mechanisms for some cell types. The results show that selective COX-2 inhibitors have the potential to improve tumor radiotherapy or radiochemotherapy, and this therapeutic strategy is currently under clinical testing. 相似文献
28.
Raju TN 《American journal of perinatology》2007,24(10):567-568
Although cesarean section is one of the most ancient surgical procedures, the origin of its name remains obscure. The term, however, did not originate because of the birth of the Roman Emperor Julius Caesar through this route. In fact, historians are certain that Julius Caesar was not delivered by the dangerous cesarean section. The evidence for this comes from indirect inferences. Cesarean sections were rarely attempted on living women until the early 17th century, and Julius Caesar's mother was alive and well through her son's adult life. Two other possible reasons for the origin of the term are discussed in this article. Mention is also made of the cesarean birth histories of some mythological characters and a few historical personalities. 相似文献
29.
Hemant Suryavanshi Raju D. Chaudhari Vishakha Patil Swapan Majumdar Sudhan Debnath Goutam Biswas 《Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences》2022,30(1):139
PurposeVortioxetine an anti-depressant FDA-drug recently reported showing better in vitro efficacy against SARS-CoV-2.MethodsIn this study, we have synthesized ten new derivatives having alkenes, alkynes, benzyl, aryl, and mixed carbamate at the N-terminal of vortioxetine. Then the binding energy and interactions with the crucial amino acid residues in the binding pocket of main protease (Mpro) of SARS-CoV-2, of reported and ten newly synthesized vortioxetine derivatives (total thirty-one) in comparison with remdesivir are analyzed and presented in this paper.ResultsBased on the docking scores predicted by ADV and AD, most vortioxetine derivatives showed better binding efficiency towards Mpro of SARS-CoV-2 in comparison with remdesivir (an EUA approved drug against SARS-CoV-2 Mpro) and vortioxetine.ConclusionThis study shows that some vortioxetine derivatives can be developed into promising drugs for COVID-19 treatment.Supplementary InformationThe online version contains supplementary material available at 10.1007/s40199-022-00441-z. 相似文献
30.