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991.
992.
Santos AC Matos CM Oliveiros B Almeida T Gano L Neves M Ferreira N 《Current radiopharmaceuticals》2012,5(2):166-174
Liposomes, usually assembled from organic/synthetic lipidic compounds, are biocompatible, biodegradable, non-toxic, and do not induce immune response. Due to their structural versatility in terms of size, composition, surface charge, bilayer fluidity and ability to encapsulate drugs regardless of their solubility, liposomes enable the production of a vast number and type of formulations with potential clinical use. They can be administered through several routes of administration (e.g. i.v., i.m., oral, nasal, etc.). The use of liposomes enables the variation and control retention of drugs in biologic fluids, enhancing blood circulation and specific compartments residence. They can be tailored to target specific tissues and cells. They can play a very important role for imaging diagnosis and/or therapy. After an extensive literature review of the subject, we selected a particular area of potential clinical application: pulmonary ?dema. This clinical entity has a variety of possible etiologies, conducing to two main types of edema: cardiogenic and non-cardiogenic. At the moment a dedicated technique for the early diagnosis/therapy of this pathology is lacking. We propose a new methodology using a specially designed GUV formulation, encapsulating chosen radiotracers labeled with 99mTc. The aim of the work has been successfully achieved in an experimental animal model of cardiogenic pulmonary oedema. Experiments using an animal model of non-cardiogenic pulmonary oedema are in course (simultaneous study with two different drugs), using the same GUV methodology. Preliminary results are very promising. 相似文献
993.
994.
Jandorf L Ellison J Shelton R Thélémaque L Castillo A Mendez EI Horowitz C Treviño M Doty B Hannigan M Aguirre E Harfouche-Saad F Colon J Matos J Pully L Bursac Z Erwin DO 《Journal of health communication》2012,17(2):160-176
Breast cancer is the most common cause of cancer and the leading cause of cancer death among Latinas in the United States. In addition, Latinas experience a disproportionate burden of cervical cancer incidence, morbidity, and mortality compared with non-Hispanic White women. Lower use of breast and cervical cancer screening services may contribute to these disparities. To address the underutilization of breast and cervical cancer screening among diverse subgroups of Latinas, a peer-led education program called Esperanza y Vida ("Hope and Life") was developed and administered at 3 sites (2 in New York and 1 in Arkansas). Immigrant Latina women and their partners were educated about the importance of breast and cervical cancer screening, with the goals of increasing their knowledge about these cancers and their screening behavior. An analysis of the intervention's findings at baseline among female participants demonstrated significant sociodemographic, interpersonal, cultural, health care system, and program variability in 3 distinct geographic regions in the United States. These data indicate the need for and feasibility of customizing cancer outreach and educational programs for diverse Latina subgroups living in various U.S. regions, with implications for informing the expansion and replication of the program in other regions of the country. 相似文献
995.
996.
Dilélio AS Facchini LA Tomasi E Silva SM Thumé E Piccini RX Silveira DS Maia Mde F Osório A Siqueira FV Jardim VM Lemões MA Borges CL 《Cadernos de saúde pública / Ministério da Saúde, Funda??o Oswaldo Cruz, Escola Nacional de Saúde Pública》2012,28(3):503-514
Mental health problems are among the most prevalent conditions in health workers. We evaluated the prevalence of minor psychiatric disorders and associated factors among primary healthcare workers. The study design was cross-sectional and services-based, in 240 primary healthcare units in 41 municipalities (counties) with more than 100 thousand inhabitants in seven States in the South and Northeast regions of Brazil. A total of 4,749 primary healthcare workers were interviewed, and prevalence of minor psychiatric disorders was 16%, with no statistical differences according to region or primary care model. The rate was higher in community health workers and other workers with secondary education (18%) and lower in health professionals with university training (10%); while physicians (15%) and nurses and nurse technicians (14.6%) were in an intermediate situation (p < 0.001). Occupational characteristics showed the strongest association with the occurrence of minor psychiatric disorders according to the adjusted analysis, suggesting that their reduction requires improvements in work conditions in primary healthcare and in the management of the Unified National Health System. 相似文献
997.
998.
Broadening the phenotypic spectrum of POP1‐skeletal dysplasias: identification of POP1 mutations in a mild and severe skeletal dysplasia 下载免费PDF全文
J. Barraza‐García C.I. Rivera‐Pedroza A. Hisado‐Oliva A. Belinchón‐Martínez L. Sentchordi‐Montané E.L. Duncan G.R. Clark A. del Pozo K. Ibáñez‐Garikano A. Offiah P. Prieto‐Matos V. Cormier‐Daire K.E. Heath 《Clinical genetics》2017,92(1):91-98
Processing of Precursor 1 (POP1) is a large protein common to the ribonuclease‐mitochondrial RNA processing (RNase‐MRP) and RNase‐P (RMRP) endoribonucleoprotein complexes. Although its precise function is unknown, it appears to participate in the assembly or stability of both complexes. Numerous RMRP mutations have been reported in individuals with cartilage‐hair hypoplasia (CHH) but, to date, only three POP1 mutations have been described in two families with features similar to anauxetic dysplasia (AD). We present two further individuals, one with severe short stature and a relatively mild skeletal dysplasia and another in whom AD was suspected. Biallelic POP1 mutations were identified in both. A missense mutation and a novel single base deletion were detected in proband 1, p.[Pro582Ser]:[Glu870fs*5]. Markedly reduced abundance of RMRP and elevated levels of pre5.8s rRNA was observed. In proband 2, a homozygous novel POP1 mutation was identified, p.[(Asp511Tyr)];[(Asp511Tyr)]. These two individuals show the phenotypic extremes in the clinical presentation of POP1‐dysplasias. Although CHH and other skeletal dysplasias caused by mutations in RMRP or POP1 are commonly cited as ribosomal biogenesis disorders, recent studies question this assumption. We discuss the past and present knowledge about the function of the RMRP complex in skeletal development. 相似文献
999.
Vanessa Teich Tony Piha Lucas Fahham Haline Bianca Squiassi Everton de Matos Paloni Paulo Miranda Denizar Vianna Araújo 《Arquivos brasileiros de cardiologia》2015,105(4):339-344
Background
Acute coronary syndrome (ACS) is defined as a “group of clinical symptoms compatible with acute myocardial ischemia”, representing the leading cause of death worldwide, with a high clinical and financial impact. In this sense, the development of economic studies assessing the costs related to the treatment of ACS should be considered.Objective
To evaluate costs and length of hospital stay between groups of patients treated for ACS undergoing angioplasty with or without stent implantation (stent+ / stent-), coronary artery bypass surgery (CABG) and treated only clinically (Clinical) from the perspective of the Brazilian Supplementary Health System (SHS).Methods
A retrospective analysis of medical claims of beneficiaries of health plans was performed considering hospitalization costs and length of hospital stay for management of patients undergoing different types of treatment for ACS, between Jan/2010 and Jun/2012.Results
The average costs per patient were R$ 18,261.77, R$ 30,611.07, R$ 37,454.94 and R$ 40,883.37 in the following groups: Clinical, stent-, stent+ and CABG, respectively. The average costs per day of hospitalization were R$ 1,987.03, R$ 4,024.72, R$ 6,033.40 and R$ 2,663.82, respectively. The average results for length of stay were 9.19 days, 7.61 days, 6.19 days and 15.20 days in these same groups. The differences were significant between all groups except Clinical and stent- and between stent + and CABG groups for cost analysis.Conclusion
Hospitalization costs of SCA are high in the Brazilian SHS, being significantly higher when interventional procedures are required. 相似文献1000.
Maria Angela Magalh?es de Queiroz Carreira André Barros Nogueira Felipe Montes Pena Marcio Galindo Kiuchi Ronaldo Campos Rodrigues Rodrigo da Rocha Rodrigues Jorge Paulo Strogoff de Matos Jocemir Ronaldo Lugon 《Arquivos brasileiros de cardiologia》2015,104(6):493-500