全文获取类型
收费全文 | 1924篇 |
免费 | 112篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 27篇 |
儿科学 | 51篇 |
妇产科学 | 38篇 |
基础医学 | 311篇 |
口腔科学 | 118篇 |
临床医学 | 135篇 |
内科学 | 427篇 |
皮肤病学 | 47篇 |
神经病学 | 105篇 |
特种医学 | 82篇 |
外科学 | 208篇 |
综合类 | 10篇 |
预防医学 | 225篇 |
眼科学 | 22篇 |
药学 | 115篇 |
中国医学 | 35篇 |
肿瘤学 | 95篇 |
出版年
2024年 | 4篇 |
2023年 | 17篇 |
2022年 | 42篇 |
2021年 | 62篇 |
2020年 | 69篇 |
2019年 | 69篇 |
2018年 | 76篇 |
2017年 | 69篇 |
2016年 | 60篇 |
2015年 | 67篇 |
2014年 | 86篇 |
2013年 | 125篇 |
2012年 | 190篇 |
2011年 | 168篇 |
2010年 | 102篇 |
2009年 | 68篇 |
2008年 | 90篇 |
2007年 | 98篇 |
2006年 | 94篇 |
2005年 | 79篇 |
2004年 | 46篇 |
2003年 | 52篇 |
2002年 | 42篇 |
2001年 | 38篇 |
2000年 | 32篇 |
1999年 | 21篇 |
1998年 | 12篇 |
1997年 | 10篇 |
1996年 | 5篇 |
1995年 | 6篇 |
1994年 | 4篇 |
1993年 | 8篇 |
1992年 | 14篇 |
1991年 | 9篇 |
1990年 | 5篇 |
1989年 | 8篇 |
1988年 | 11篇 |
1987年 | 18篇 |
1986年 | 10篇 |
1985年 | 11篇 |
1984年 | 6篇 |
1983年 | 7篇 |
1982年 | 4篇 |
1980年 | 3篇 |
1976年 | 3篇 |
1975年 | 2篇 |
1974年 | 3篇 |
1971年 | 2篇 |
1970年 | 5篇 |
1969年 | 4篇 |
排序方式: 共有2051条查询结果,搜索用时 15 毫秒
91.
Italo Wanderson de Moura Gabriel Danielly Gon alves Sombra Lima Jeully Pereira Pires N lio Barreto Vieira Aloisio Antonio Gomes de Matos Brasil Yara Talita Gomes Pereira Erika Galvao de Oliveira Hildson Leandro de Menezes Nadia Nara Rolim Lima Alberto Olavo Adv ncula Reis Ruan Neto Pereira Alves Uanderson Pereira da Silva Jucier Gon alves Junior Modesto Leite Rolim-Neto 《World Journal of Psychiatry》2022,12(11):1313-1322
92.
93.
Alexandre de Matos Soeiro Felipe Louren?o Fernandes Rafael Plens Teixeira Pedro Felipe Gomez Nicz Maria Carolina Feres de Almeida Soeiro Carlos V. Serrano Jr. Múcio Tavares de Oliveira Jr. 《Brazilian Journal Of Cardiovascular Surgery》2014,29(2):285-288
Insertion of inferior vena cava filters has been well established in literature,
reducing occurrence of pulmonary embolism after an episode of deep venous thrombosis
in patients with contraindication to anticoagulation. There are a small number of
complications related to procedure and embolization is rare. In this context, we
described a case of intracardiac embolization associated with cardiac tamponade. 相似文献
94.
Gardênia Matos Paraguassú Milena Góes da Guarda Flávia Calo Aquino Xavier Maria Cristina Teixeira Cangussu Tânia Tavares Rodriguez Maria José Pedreira Ramalho Antônio Luis Barbosa Pinheiro Luciana Maria Pedreira Ramalho 《Lasers in medical science》2014,29(2):773-779
The aim of this study was to assess morphometrically and histologically, the effects of light-emitting diode (LED) (λ630?±?20 nm) phototherapy on reepithelialization and wound contraction during tissue repair in hypothyroid rats. Thyroid hormone deficiency has been associated with disorders of tissue repair. LED phototherapy has been studied using several healing models, but their usefulness in the improvement of hypothyroidism wound healing remains unknown. Under general anesthesia, a standard surgical wound (1 cm2) was produced on the dorsum of 48 male Wistar rats divided into four groups of 12 animals each: EC—control euthyroid, ED—euthyroid + LED, HC—control hypothyroid, and HD—Hypothyroid + LED. The irradiation started immediately after surgery and was repeated every other day for 7 and 14 days. Photographs of the wound were taken at the day of the surgical procedure and on days 8 and 15 after surgery, when animals’ deaths occurred. The specimens were removed, routinely processed, and stained with hematoxylin/eosin. Seven days after the surgery, it was possible to observe statistically significant reductions in the wound area of the irradiated euthyroid group, in comparison to hypothyroid group, irradiated and non-irradiated (ANOVA, p?<?0.05). The reepithelialization was significantly higher in the euthyroid and hypothyroid groups irradiated with LED than in the non-irradiated groups (Fisher’s test, p?<?0.05). No significant difference was found in the experimental period of 14 days among the groups. The hypothyroidism delayed wound healing and the LED phototherapy, at these specific parameters, improved the process of reepithelialization in the presence of hypothyroidism. 相似文献
95.
C. G. Pereira-lucena R. Artigiani Neto D. T. de Rezende G. de J. Lopes-Filho D. Matos M. M. Linhares 《Hernia》2014,18(4):563-570
Purpose
Although meshes reduce abdominal hernia recurrence, they increase the risk of inflammatory complications. This study aimed to compare the early and late postoperative inflammation and collagen deposition responses induced by three meshes.Methods
Rats were allocated into three groups. In group I, a polypropylene (PP) mesh was implanted in the abdominal wall. In groups II and III, PP + polyglactin (PP + PG) and PP + titanium (PP + TI) meshes were employed, respectively. On the seventh (7th) postoperative day, collagen deposition and inflammation were evaluated, and immunohistochemistry was performed on abdominal wall biopsies. These data were compared with those obtained on the fortieth (40th) postoperative day in a previous study.Results
The early inflammatory responses were the same in all groups. With time, it decreased in group I (p = 0.047) and increased in group II (p = 0.003). Group I exhibited early elevated VEGF (p < 0.001), COX2 (p < 0.001), and collagen (p = 0.023) levels, and group II exhibited the most severe inflammatory tissue response. On the 40th postoperative day, the VEGF (p < 0.001) and collagen (p < 0.005) were reduced as compared with the 7th postoperative day in all groups.Conclusions
Belatedly, the inflammatory reaction decreased in PP mesh group and increased in PP + PG mesh group. The PP mesh induced early great elevations in VEGF, COX2 and collagen levels, whereas the PP + PG mesh caused severe tissue inflammation with small elevation in these levels. PP + TI mesh induced inflammatory response levels between the others. In conclusion, the inflammatory response depends on the mesh density and also the mesh material with clinical implications. 相似文献96.
97.
98.
Luís Carlos Matos Jorge Machado Henry Johannes Greten Fernando Jorge Monteiro 《Journal of bodywork and movement therapies》2019,23(4):713-720
Qigong is a therapeutic method of traditional Chinese medicine (TCM) that combines slow, soft movements and postures with breath control and a special mental state of ‘awareness’. TCM holds that the practice of Qigong promotes the ‘circulation of qi’ in the human body, the ‘flow’ of upward yang qi and downward yin qi to establish ‘balance’. In Western terms, this may be generally equivalent to vegetative homeostasis and the emotionally balanced state induced thereby. Researchers have often attempted to evaluate the functional movements of qi using measurements of the skin's electrical resistance. However, these methodologies have proven difficult to gauge, validate, repeat, and interpret. We aimed to overcome these limitations by measuring the skin's electrical potential between two points of the same system. The main goal of this study was to assess the skin's electrical potential changes in acupoints from the Ren Mai and Du Mai conduits, or meridians, as well as in other points of interest, during Qigong practice. While participants performed a specific Qigong exercise called ‘White Ball’, we observed significant changes in the skin electrical potential on Mìngmén (GV 4), Shèndáo (GV 11) and Baihuì (GV 20), from the Du Mai conduit, as well as on Huiyin (CV 1), Qìhai (CV 6), Zhongwan (CV 12) and Dànzhong (CV 17), from Ren Mai. These observations are in accordance with TCM theory and may contribute to the explanation of the vegetative physiological changes that are associated with ‘qi flow’ in TCM. 相似文献
99.
R Damle J Levine J Matos S Greenberg R Brooks W Frumkin J Goldberger A H Kadish 《Annals of internal medicine》1992,116(5):375-381
OBJECTIVE: To assess the efficacy and toxicity of moricizine in treating patients with serious ventricular arrhythmias and inducible sustained ventricular tachycardia. DESIGN: Uncontrolled clinical trial. SETTING: The intensive care and telemetry units of Northwestern Memorial Hospital, St. Francis Hospital and Medical Center, and Lenox Hill Hospital. PATIENTS: Twenty-six patients with sustained ventricular arrhythmias or hemodynamically significant nonsustained ventricular tachycardia, most of whom failed therapy with at least one class I antiarrhythmic agent. INTERVENTION: Patients were treated with moricizine, 400 to 1000 mg/d. MEASUREMENT: Efficacy was assessed by the results of programmed ventricular stimulation done during moricizine therapy. MAIN RESULTS: Seven of the 26 patients (27%) developed life-threatening ventricular proarrhythmia during moricizine loading. Three patients had incessant sustained ventricular tachycardia, two had incessant nonsustained ventricular tachycardia, one had new sustained ventricular tachycardia, and one had new cardiac arrest. One of these patients died of intractable ventricular fibrillation. No clinical or electrophysiologic variables clearly identified those at risk for proarrhythmia. Only 3 of 26 patients (12%) became noninducible on moricizine. CONCLUSION: Moricizine has a low rate of efficacy and carries a considerable risk for life-threatening proarrhythmia in patients with serious ventricular arrhythmias and inducible ventricular tachycardia who have failed therapy with other class I antiarrhythmic agents. 相似文献
100.
Vanderborght PR Matos HJ Salles AM Vasconcellos SE Silva-Filho VF Huizinga TW Ottenhoff TH Sampaio EP Sarno EN Santos AR Moraes MO 《International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association》2004,72(2):143-148
Tumor necrosis factor alpha (TNFalpha) plays a key role in orchestrating the complex events involved in inflammation and immune response. The presence of single nucleotide polymorphisms (SNPs) within the promoter region of the TNFa gene has been associated with a number of diseases. The aim of this study was to investigate the distribution of polymorphisms at positions -238 (G/A) and -308 (G/A) at the TNFalpha promoter, and its association to the outcome of different clinical forms of leprosy. Furthermore, the bacteriological index (BI) was evaluated among genotyped multibacillary (MB) patients in order to investigate the possible influence of each polymorphism on the bacterial load. This study included a total of 631 leprosy patients being 401 MB and 230 paucibacillary (PB), that was further separated according to its ethnicity (Afro- and Euro-Brazilians). The combination of SNPs in haplotypes generated three different arrangements: TNFG-G, TNFG-A and TNFA-G. In spite of the marked differences observed in the frequency of the haplotypes along the ethnic groups, no statistical differences were observed in haplotype frequencies between MB and PB patients. The BI analyses showed a lower bacteriological index among the -308 carriers, while the BI of the -238 carriers was higher. Although no significance has been achieved in this analysis regarding the influence of the polymorphisms to the development of the clinical outcome, it seems that in a different stage (among the MB patients) the polymorphisms could contribute to the degree of severity observed. 相似文献