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Inflammatory pseudotumors have been recognized in many parts of the body. A case of a diffuse variant which involved the testis,
the epididymis and the spermatic cord is described. The patient had enlarged left testis for several months. Clinically, the
lesion mimicred cancer. Histologically, the lesion contained hyalinized fibrous tissue with spindle cells, plasma cells and
lymphocytes. Gradual involvement of vascular channels by the cellular elements of inflammatory pseudotumor was observed. Results
of immunohistochemical studies showed a myofibroblast differentiation in the majority of spindle cells: intense antibody staining
for smooth muscle actin, muscle specific actin, and vimentin. The ultrastructural findings, intracytoplasmic filaments with
dense bodies, were also consistent with the myofibroblastic nature of these cells. The histiocyte differentiation of spindle
cells is questionable in our case, because only scattered histiocyte-like cells showed positivity with the KP-1 (CD-3) antibody. 相似文献
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Rennan Garcias Moreira Julia Maria SaraivaDuarte Alexandre Costa Pereira Martha SosaMacias Carlos GalavizHernandez Meddly Lesley Santolalla Wagner C. S. Magalhes Camila Zolini Thiago Peixoto Leal Zsolt Balzs Adrin Llerena Robert H. Gilman Jos Geraldo Mill Victor Borda Heinner Guio Timothy D. OConnor Eduardo TarazonaSantos Fernanda RodriguesSoares 《CTS Clinical and Translational Science》2022,15(6):1400
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Zsolt Balogh Cino Bendinelli Timothy Pollitt Rosemary A. Kozar Frederick A. Moore 《European journal of trauma and emergency surgery》2008,34(4):369-377
Postinjury abdominal compartment syndrome (ACS) has evolved during the 1980s together with the introduction of damage control
surgery (DCS) principles. DCS made it possible to salvage severely injured trauma patients who previously would have exsanguinated
due to uncontrollable coagulopathic bleeding. These patients had severe hemorrhagic shock; their abdomens were tightly packed
and had ongoing massive resuscitation. ACS is a lethal complication of the damage control patients. For today the pathophysiological
characteristics of ACS are described, the intra-abdominal pressure is measured on many intensive care units. Postinjury ACS
(primary and secondary) is one of the better characterized etiological types of ACS: risk factors, diagnostic criteria, independent
predictors and preventive strategies are all well documented. Since the mortality of full-blown postinjury ACS is still unacceptably
high and does not seem to improve with earlier decompression, prevention is the recommended strategy to decrease the morbidity
and mortality. Open abdomen is one of the important preventive strategies but it is not free from morbidity and mortality.
With aggressive open abdomen management in postinjury ACS these complications can be minimized. More importantly, timely hemorrhage
control and hemostatic resuscitation are the likely solutions for more efficient prevention of the postinjury ACS. 相似文献
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IntroductionThe importance of the abdominal wall characteristics in intraabdominal pressure (IAP), intraabdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are poorly understood. The applicability of laboratory research findings to human scenarios is unknown due to the potential differences in abdominal wall elastance (AWE) amongst species. The aims of the study are to describe the AWE curve in rabbits and to compare it to the available human data.Materials and methodsProspective experimental animal study in the setting of research laboratory. Male New Zealand White rabbits weighting 2.7 kg ± 0.1 kg, were anesthetized and the AWE was determined by infusion of lactated Ringer's solution into the peritoneal cavity whilst the IAP was measured. A meta-analysis of peer-reviewed studies was conducted to define human AWE.ResultsThe described AWE was lower in the rabbit than in humans. The function comparing human and rabbit was: loge human IAP = (0.58 loge rabbit IAP + 1.6).ConclusionsThe AWE can vary amongst species. This study determined the relationship to allow the comparison of rabbit and human IAP. The proposed mathematical function is important for the advancement of interpretation and understanding of animal research into IAH and ACS. We recommend developing model-specific functions comparing individual animal models’ IAP and that of humans. 相似文献
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