Oral use of chlorhexidine gluconate toothpaste in epileptic children

abstract — The purpose of this clinical study was to evaluate the effect of a 3-min daily toothbrushing with 1% chlorhexidine gluconate toothpaste on dental plaque, gingivitis and gingival hyperplasia in 30 mentally retarded epileptic children treated with phenytoin. A double-blind cross-over technique was used. Brushing once daily for 2 months with 1% chlorhexidine gluconate toothpaste resulted in significantly lower Pl I and GI values. Gingival hyperplasia was not significantly reduced by the use of the chlorhexidine toothpaste.     

Prostaglandins in the Toxemia of Pregnancy

The toxemia of pregnancy still remains a serious obstetric disease to which nearly one-third of all maternal deaths are attributable. Although the etiology of toxemia is unknown, a uteroplacental ischemia is believed to be the physiopathologic cause. A hypothesis is presented which implicates placental prostaglandins in the etiology of this disease.     

Postoperative hypotension associated with enalapril

We describe the case of a patient treated for hypertension with the angiotensin converting enzyme inhibitor enalapril, who developed hypotension after recovery from anaesthesia.     

The relationship between the concentration of temazepam in cerebrospinal fluid and sedation in man

Twenty-six patients received oral temazepam and subsequently spinal anaesthesia. Blood and lumbar cerebrospinal fluid temazepam levels were measured together with the degree of sedation. The plasma and cerebrospinal fluid concentrations correlated well with the temazepam dose but even better with the weight standardised dose (r = 0.65, p = 0.0003 and r = 0.75, p = 0.00001 respectively). Both the plasma and cerebrospinal fluid concentrations of temazepam were correlated with the patient's sedation (r = 0.42 p = 0.037, and r = 0.46 p = 0.021 respectively), but neither was strong. Thus, although the drug concentration at the receptor may be a major factor in producing sedation, other factors, possibly the receptor population or their responsiveness, are also important contributors.     

Sudoriferous hamartoma

Localized hyperhidrosis seldom occurs at sites other than the palms, soles and forehead. However, localized hyperhidrosis can occur at other sites in the rare eccrine naevus which is characterized by hypertrophy and hyperplasia of sweat and/or sebaceous glands. A case of an unusual sudoriferous hamartoma is described in which circumscribed hyperhidrosis was a prominent feature.