全文获取类型
收费全文 | 2646589篇 |
免费 | 199858篇 |
国内免费 | 5031篇 |
专业分类
耳鼻咽喉 | 37900篇 |
儿科学 | 84184篇 |
妇产科学 | 76198篇 |
基础医学 | 372189篇 |
口腔科学 | 79781篇 |
临床医学 | 230241篇 |
内科学 | 514046篇 |
皮肤病学 | 58564篇 |
神经病学 | 213543篇 |
特种医学 | 105742篇 |
外国民族医学 | 879篇 |
外科学 | 405180篇 |
综合类 | 64436篇 |
现状与发展 | 9篇 |
一般理论 | 923篇 |
预防医学 | 196482篇 |
眼科学 | 62362篇 |
药学 | 199874篇 |
7篇 | |
中国医学 | 5403篇 |
肿瘤学 | 143535篇 |
出版年
2018年 | 24350篇 |
2015年 | 24537篇 |
2014年 | 34010篇 |
2013年 | 52062篇 |
2012年 | 69359篇 |
2011年 | 73231篇 |
2010年 | 43508篇 |
2009年 | 41607篇 |
2008年 | 70294篇 |
2007年 | 75151篇 |
2006年 | 76088篇 |
2005年 | 73983篇 |
2004年 | 72361篇 |
2003年 | 69771篇 |
2002年 | 68485篇 |
2001年 | 122396篇 |
2000年 | 126126篇 |
1999年 | 107467篇 |
1998年 | 29347篇 |
1997年 | 26684篇 |
1996年 | 26152篇 |
1995年 | 25134篇 |
1994年 | 23628篇 |
1993年 | 22161篇 |
1992年 | 86604篇 |
1991年 | 83976篇 |
1990年 | 82219篇 |
1989年 | 80121篇 |
1988年 | 74598篇 |
1987年 | 73443篇 |
1986年 | 70117篇 |
1985年 | 67278篇 |
1984年 | 50409篇 |
1983年 | 43269篇 |
1982年 | 25705篇 |
1981年 | 23238篇 |
1980年 | 21793篇 |
1979年 | 48310篇 |
1978年 | 34067篇 |
1977年 | 29087篇 |
1976年 | 26841篇 |
1975年 | 29329篇 |
1974年 | 35487篇 |
1973年 | 34227篇 |
1972年 | 32045篇 |
1971年 | 30137篇 |
1970年 | 28146篇 |
1969年 | 26743篇 |
1968年 | 24857篇 |
1967年 | 22389篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
41.
42.
In cystic fibrosis (CF), perturbations of total daily energy expenditure (TDEE) may be a major determinant of altered nutrition and growth. Measurement of TDEE is problematic, though the flex-heart rate method (FHRM) provides a close estimation of TDEE, as compared to the cost-prohibitive, gold standard, the double-labeled water method, and permits estimates of the energy cost of daily activities (ECA) above resting energy expenditure (REE). We hypothesize that alterations in ECA affects TDEE in CF. PURPOSE: To measure components of TDEE in adolescents with CF and normal lung function compared with controls, and to determine whether ECA can be improved by diet and exercise. METHODS: Clinically stable CF subjects (aged 9-13, n=12) and age- and gender-matched controls (n=13) had repeated measurements of TDEE by FHRM, REE, and maximal cardiopulmonary exercise testing (CPET) during a 6-week exercise and diet program. RESULTS: While the mean REE was similar in both groups, ECA was significantly lower in CF adolescents as compared to controls (p=0.02). During CPET, maximal exercise in CF was characterized by hyperventilation, which was unrelated to ventilation-perfusion mismatching. There were no changes in REE after dietary intervention. CONCLUSION: ECA in CF adolescents with normal lung function is lower when compared to healthy controls. These findings support the hypothesis that clinically stable patients with CF have inefficient energy metabolism or alternatively conserve energy during activities of daily living. 相似文献
43.
Deng H. Le W. - D. Hunter C. B. 《世界核心医学期刊文摘》2006,2(6):17-18
背景:Parkin基因(PRKN)突变可导致常染色体隐性遗传性早发帕金森病(EOPD)。目的:探讨EOPD白人家族PRKN突变的表现和基因型-表型关系。设计:对EOPD家族的3代20例成员进行基因分析,该家族有4例患者。应用直接基因组DNA测序、半定量聚合酶链反应、实时定量聚合酶链反应以及逆转录酶聚合酶链反应分析以确定PRKN突变。结果:4例早发患者(年龄30—38岁)被确定有PRKN复合杂合突变(T240M和EX5_6缺失),虽然PRKN的杂合T240M和纯合EX5_6缺失突变已有描述,但是据悉,本文为上述复合杂合突变的首次报道。患者的表型为典型常染色体隐性遗传性EOPD的表现,其特征是对左旋多巴治疗有效、相对缓慢的进展和运动障碍。所有杂合突变的基因携带者(T240M或EX5_6缺失)和1例56岁的复合杂合突变女性携带者(T240M和EX5_6缺失)无任何神经系统症状。结论:研究发现,PRKN基因复合杂合突变(T240M和EX5_6缺失)导致一个大的白人家族中4例成员发生常染色体隐性遗传性EOPD。另外1例成员具有相同的突变,比4例患者的平均发病年龄大10岁,并且无本病的临床表现。不完全的外显率对遗传咨询具有暗示作用,并且提示复杂的基因一环境交互作用在PRKN相关EOPD的发病机制中发挥作用。 相似文献
44.
Hasan Sunar Gülara Hüseyinova Suat Canbaz Umit Halici Enver Duran 《Blood coagulation & fibrinolysis》2003,14(8):703-706
Low molecular weight heparins are widely used in the prophylaxis and treatment of thrombotic disorders. The effect of low molecular weight heparins on coagulation was examined ultrastructurally in an animal model. A test and a control group was formed, each consisting of five rabbits. Nadroparine (225 Institute of Chaoy Unit/kg twice daily) was applied to the test group for 10 days. The control group received 1 ml saline solution subcutaneously. Blood and vascular tissue samples collected at the end of the 10th day were evaluated under a JEM 100 B electron microscope. Platelet degranulation and agglutination was observed in the control group. Fibrin materials were detected in the cytoplasms and surroundings of degranulated platelets. Erythrocyte accumulation was remarkable on the vascular endothelium with intact coagulation periods. In the test group, outer membranes of platelets, hyalomere, and granular structures in the granulomeres were detected to be nearly intact. There were rare erythrocytes in the large vascular lumens. The aggregation phase had occurred but no agglutination was detected. Nadroparine seems to preserve consistency of lipoprotein membranes of platelets and granular structures containing enzymes, which contribute to the coagulation mechanisms. 相似文献
45.
S. Spinty H. Rogozinski G. T. Lealman J. E. Wraith 《Journal of inherited metabolic disease》2003,25(8):697-698
Summary: A female patient with isovaleric acidaemia had a successful outcome from pregnancy. 相似文献
46.
47.
48.
49.
50.
To determine if impaired energy metabolism might contribute to some aspects of Alzheimer disease (AD), including the vulnerability of the CA1 region of the hippocampal formation and the altered cytoskeleton evident in neurofibrillary tangles, we examined the effects of metabolic poisons on neuronal damage and cytoskeletal disruption in the hippocampal formation. Intrahippocampal injection of 3-nitropropionic acid (3-NP) and malonic acid resulted in neuronal death, particularly in CA1. Cytoskeletal disruption included loss of dendritic MAP2, but sparing of axonal τ. MK-801 (a noncompetitive NMDA receptor antagonist) did not atenuate the lesions produced by intrahippocampal injection of malonate. MK-801, however, was effective against intrastriatal malonate. Acute systemic 3-NP resulted in neuronal damage and cytoskeletal disruption in the CA1 region of the hippocampal formation, including an extensive loss of MAP2 immuno-reactivity, but sparing of τ. The neuronal loss in CA1 was delayed as compared to striatum. Chronic intraventricular infusion of 3-NP produced a different pattern of neuronal damage. Loss of τ-1 immuno-reactivity was observed in CA3 and CA1 s. oriens, whereas MAP2 immunostaining was preserved. These results demonstrate that chronic and acute administration of metabolic inhibitors produce distinct patterns of neuronal damage and cytoskeletal disruption. The results further suggest a differential involvement of the NMDA receptor in malonate-induced neuronal damage in striatum as compared to the hippocampus. The pattern of neuronal damage and cytoskeletal disruption observed following acute metabolic impairment resembled some aspects of neurofibrillary pathology in AD, but did not result in τ hyperphosphorylation. 相似文献