二氧化碳气腹对心肌酶谱的影响

目的：研究腹腔镜胆囊切除术（ＬＣ）时ＣＯ２人工气腹对心肌酶谱的影响。方法：选择３０例ＡＳＡⅠ～Ⅱ级患慢性胆囊炎、胆石症择期手术的病人，行静脉复合麻醉。于麻醉诱导前、ＣＯ２气腹前、气腹后１５ｍｉｎ和３０ｍｉｎ及放气后５ｍｉｎ分别采集静脉血标本测定心肌酶谱（ＬＤＨ、ＣＫ、ＨＢＤＨ）。结果：麻醉诱导前后，以及ＣＯ２气腹后１５ｍｉｎ和３０ｍｉｎ及放气后５ｍｉｎ与气腹前比较心肌酶无明显变化（Ｐ〉０．０５）。ＣＯ２气腹后３０ｍｉｎ和水毕放气后５ｍｉｎ与气腹前比较ＬＤＨ虽有升高，但无统计学差异（Ｐ〉０．０５）。结论：ＬＣ时ＣＯ２人工气腹对心肌酶谱无明显影响。     

从“一气周流”理论论治肺结节

肺结节的发病率逐年升高，黄元御提出中土斡旋、木火升发、金水敛降的“一气周流”理论。本文基于此理论探讨肺结节的病机及治法，认为肺结节病机为中土虚衰，斡旋失司，气机失调，遂生痰湿瘀血等阴邪，并凝聚于肺络；加之机体阳气不足，阴邪无以消散，日久而成结节；结节既成，又影响肝木升发、肺金肃降，导致机体气机失衡更甚。基于以上的病机认识，本病应采取培土生金、益气化湿，补火助阳、消积散结，升木达郁、敛金降逆的治法，旨在恢复体内之“一气周流”。     

影响阴道分娩产妇产后出血的危险因素分析

目的:探讨影响阴道分娩产妇产后出血的相关危险因素,为其临床防治提供可参考依据。方法:共纳入50例入住我院的出现产后出血的阴道分娩产妇作为病例组,同时随机抽取100例正常分娩无产后出血发生的阴道分娩产妇作为对照组,详细记录其病史及相关信息。应用多因素回归分析进行产后出血相关危险因素分析。结果:病例组患者年龄≥35岁27例占54.0%,胎次≥2次26例占52.0%,胎盘滞留30例占60.0%,胎盘粘连26例占52.0%,宫缩乏力27例占54.0%,妊娠高血压26例占52.0%,经产妇30例占60.0%,软产道损伤26例占52.0%,中重度贫血30例占60.0%,既往有不良孕产史30例占60.0%;对照组患者年龄≥35岁17例占17.0%,胎次≥2次25例占25%,胎盘滞留28例占28.0%,胎盘粘连25例占25%,宫缩乏力17例占17.0%,妊娠高血压25例占25%,经产妇40例占40.0%,软产道损伤28例占28.0%,中重度贫血40例占40.0%,既往有不良孕产史40例占40.0%;两组间差异比较有统计学意义(P0.05)。进一步多因素分析显示胎盘滞留、胎盘粘连、宫缩乏力、软产道损伤是妊娠妇女产后出血发生的独立危险因素(P0.05)。结论:阴道分娩妇女产后出血发生受胎盘滞留、胎盘粘连、宫缩乏力、软产道损伤的影响,在临床实际工作中对上述可干预因素进行必要的干预,可能降低产后出血的发生。     

FGF/FGFR system in the central nervous system demyelinating disease: Recent progress and implications for multiple sclerosis

Background

With millions of victims worldwide, multiple sclerosis is the second most common cause of disability among young adults. Although formidable advancements have been made in understanding the disease, the neurodegeneration associated with multiple sclerosis is only partially counteracted by current treatments, and effective therapy for progressive multiple sclerosis remains an unmet need. Therefore, new approaches are required to delay demyelination and the resulting disability and to restore neural function by promoting remyelination and neuronal repair.

Aims

The article reviews the latest literature in this field.

Materials and methods

The fibroblast growth factor (FGF) signaling pathway is a promising target in progressive multiple sclerosis.

Discussion

FGF signal transduction contributes to establishing the oligodendrocyte lineage, neural stem cell proliferation and differentiation, and myelination of the central nervous system. Furthermore, FGF signaling is implicated in the control of neuroinflammation. In recent years, interventions targeting FGF, and its receptor (FGFR) have been shown to ameliorate autoimmune encephalomyelitis symptoms in multiple sclerosis animal models moderately.

Conclusion

Here, we summarize the recent findings and investigate the role of FGF/FGFR signaling in the onset and progression, discuss the potential therapeutic advances, and offer fresh insights into managing multiple sclerosis.     

生物碱类天然药物抗痛风作用及作用机制的研究进展

痛风是由于机体嘌呤代谢异常和(或)尿酸排泄障碍所致的一组异质性疾病。生物碱是一类含有氮的有机化合物,广泛存在于植物中,用于痛风等多种疾病引起的炎症反应。通过查阅国内外最新相关文献报道,对生物碱抗痛风作用及作用机制的研究进展进行综述,以期为生物碱的进一步研究和临床应用提供科学依据和理论指导。     

200例过敏性肺病体质特点的调查与分析

目的　探讨过敏性肺病（变应性鼻炎、咳嗽变异性哮喘）与相关体质类型的联系。方法　采用临床流行病学调查方法，运用中医体质调查表和变应性鼻炎及咳嗽变异性哮喘临床调研表对160例变应性鼻炎患者，40例咳嗽变异性哮喘患者进行相关体质类型的调查。结果　200例过敏性肺病（变应性鼻炎、咳嗽变异性哮喘）患者中，第一体质为阳虚体质，第二体质为气虚体质。在第一体质为阳虚质患者中，兼夹气虚质最多，为21.7％；其次，兼夹特禀质所占比例为20.3％. 结论　过敏性肺病的形成与阳虚质、气虚质、特禀质关系最为密切。