大鼠摄入铝,氟及其不同比例混合物后血和骨中铝氟含量分析

Wistar rats were divided into 8 groups:control, 300 ppm F, 130 ppm F, 300 ppm Al, 1200 ppm Al, 130 ppm Al + 130 ppm F. 300 ppm Al + 300 ppm F and 1200 ppm Al + 300 ppm F. The chemicals were mixed into the standard diet. The animals were fed on the diets for 12 weeks. Contents of F, Al, Ca and P in the blood (or serum) and humerus were determined at the end of 12 weeks. The results showed that the level of F in the blood and bone in the unadulterated F group was increased, especially F in the bone reached a level more than 10 times that of the control. In the 3 mixture groups, blood F and bone F were lowered, while blood F was restored to normal level, but bone F was not nevertheless, the results showed that Al was in antagonism to the absorption of F. In the unadulterated Al groups, blood and bone Al did not parallel with the amount of Al administered. The level of Al in the median Al group was higher than that of the high Al group. Taking the level of blood and bone Al as a measure, when different doses of Al were administered with F, in the low and median dosage of Al, F was in antagonism to Al absorption, but in case of high dosage of Al, F was in potentiation to Al absorption. In all the experimental groups serum P was elevated, but serum Ca was not disturbed. Bone Ca and P were decreased only in the 3 groups with unadulterated F as well as unadulterated and adulterated high dosage of Al. Mechanism of the nonlinearity of Al absorption vs Al dosage, as well as the dual effect of F on the absorption of Al was proposed.     

下腔静脉滤器在治疗下肢深静脉血栓中的应用

目的：探讨下腔静脉滤器在治疗下肢深静脉血栓(DVT)中的应用价值。方法：选择10例DVT患，使用进口铁质滤器，经股静脉或颈静脉途径置人下腔静脉，随访8—20个月。结果：10例患中无一例发生肺动脉栓塞和其他严重并发症。结论：下腔静脉滤器置人方法简单，安全；可有效防止肺动脉栓塞的发生。     

反相高效液相色谱法同时测定水杨酸原料中水杨酸和微量杂质苯酚含量

本文采用反相高效液相色谱法同时测定水杨酸原料中水杨酸及微量杂质苯酚含量。该法简便、快速、样品测定在１０ｍｉｎ内完成，其中水杨酸平均回收率为１００．４２％（ＲＳＤ１．４５％），苯酚平均回收率为１０２．２７％（ＲＳＤ２．１２％）。     

传染病研究40年（1955～1995年）

本文综述本校传染病学教研室１９５５～１９９５年间所取得的科研成果。内容包括１０余种传染病与寄生虫病的临床和基础研究，其中以华支睾吸虫病、恙虫病等有广东特色的传染病以及伤寒、痢疾、病毒性肝炎等影响人民健康最普遍的传染病为重点。反映了建国以来各个时期本教研室对防治这些传染病所作的贡献。所取得的成果，相当一部分通过多年来的验证，已获得广大传染病工作者所认同或列为常规，部分已获得部委级奖励。现在重温这些成果，可能起承前启后的意义。     

Effect of exogenous progesterone administration on the morphology of normally developing endometrium in the pre-implantation period

The effects on endometrial morphology of a single, intramuscular dose of 100 mg of progesterone administered in the early luteal phase, between days LH + 1 and LH + 6, were studied in a group (n = 8) of normal, fertile subjects by morphometric techniques and transmission electron microscopy. While the dose of progesterone administered consistently resulted in an increase of salivary progesterone concentration to above the upper limit of the reference range, no significant effect on endometrial development was observed; in particular, endometrial development was not advanced.     

In vitro histoculture of human tumors with fluorescent dye end-points measured by confocal microscopy: high correlation of in vitro and in vivo chemosensitivity.

Tumors from 40 patients and 7 established human xenograft tumor lines were grown in three-dimensional histoculture. A Viable-Cell-Index (VCI) based on fluorescent dyes and Growth Fraction Index (GFI) based on [3H]thymidine incorporation were measured by confocal microscopy and histological autoradiography, respectively, after treatment with cytotoxic agents. Chemosensitivity in vitro with the two methods was correlated with chemosensitivity of the same set of human xenografted tumor lines grown in nude mice. The percent accuracy of in vitro to in vivo correlation with VCI (73%) was higher than GFI (63%). The number of false positives with VCI was 12.1% (4/33), and with GFI was 31.3% (10/32). The results thus indicated that in vitro histoculture with fluorescent vital-dye end-points to measure cell viability is of potential use to determine tumor chemosensitivity.     

达菲林在体外受精-胚胎移植中的应用

目的:观察达菲林在体外受精-胚胎移植中的疗效。方法:根据112例不孕患者用药前窦卵泡的数目采用不同剂量的达菲林降调节,常规超促排卵至卵泡成熟后,经阴道B超引导下取卵,行实验室体外培养受精,优质胚胎移植。结果:3组获卵数、获得的Ⅰ级胚胎数、胚胎移植后临床妊娠率、卵巢过度刺激综合征发生率等均无明显差异,受精率皆在70％以上,卵裂率在93％以上。结论:不同剂量的达菲林降调节均可获得高质量的卵子,且是一种肌肉注射缓释剂,易被患者接受。     

Differences in the hypothermic response to ethanol in rats selectively bred for oral ethanol preference and nonpreference

The duration of retention of tolerance to ethanol was tested in the alcohol-preferring (P) and alcohol-nonpreferring (NP) rats lines, using ethanol-induced hypothermia as a measure of tolerance. Rats received two injections of ethanol (3.5 g/kg) body wt, IP) and the time between the injections was 1, 2, or 3 days. When one day separated the two injections, tolerance to the hypothermic effect of a second “test” injection was found in both lines. When 2 or 3 days separated the two injections, the P line showed a loss of tolerance and the NP line showed sensitization to ethanol. Sensitization in the NP line grew stronger when the interval between injections was increased from 2 to 3 days. The duration of retention of tolerance to ethanol-induced hypothermia in the P line was shorter than has previously been reported for motor impairment in this line. It appears that the duration of tolerance retention in the P line depends on the test used to measure tolerance. Sensitization to ethanol in the NP line may be associated with low oral ethanol intake. This research was supported, in part, by grants AA08312, AA03243, and AA07611 from the PHS     

二期后房型人工晶体植入术

本文报道对16只(16例)后囊膜完整的无晶体眼进行后房型人工晶体二期植入术的结果.术前的平均未矫正视力为0.06,术后半年,平均未矫正视力为0.53未矫正视力≥0.5的达62.50%,矫正视力≥0.5的占93.37%,≥1.0的占81.25%.术前角膜中央内皮细胞密度平均2646个/mm~2,术后半年为1824个/mm~2,除一例外,其余可恢复立体视.无一例发生持续性角膜水肿和葡萄膜炎等严重并发症.结果表明,只要掌握适应症和手术技术,在后囊膜完整的无晶体眼作二期后房型人工晶体植入是安全有效的方法.本文对手术的适应症、手术方式和技术进行了探讨.     

包头市区400名健康成年人发硒值测定

报告用巯基棉（ＳＣＦ）吸附富集分离──催化动力学法，测定了包头市区４００名１８～５５岁健康成年人发硒值。结果显示：发硒值的中位数（Ｍ）为０．７６ｍｇ／ｋｇ。男女分组分析，男性的Ｍ为０．６９ｍｇ／ｋｇ，女性Ｍ为０．８０ｍｇ／ｋｇ，男女两组间的差异无显著意义（Ｐ＞０．０５）。