Prone versus Barts “flank-free” modified supine percutaneous nephrolithotomy: a match-pair analysis

Background/aimIn this study, we aimed to compare the results of prone and Barts “flank-free” modified supine percutaneous nephrolithotomy (PCNL) operations in our clinic.Materials and methods The data from patients that underwent Barts “flank-free” modified supine PCNL (BS-PCNL) (n = 52) between June 2018 and July 2020 and prone PCNL (P-PCNL) (n = 286) between April 2014 and June 2018 were retrospectively evaluated. Of those 286 patients, 104 patients whose sex, age, body mass index, American Society of Anesthesiology score, stone localization, stone size, and hydronephrosis matched the BS-PCNL group in a 1:2 ratio were included in the study. The groups were compared in terms of intraoperative outcome, complication rates, and stone-free rates.Results The mean age of all patients (58 females, 98 males) included in the study was 41.8 ± 15.2 years, and the mean body mass index (BMI) was 24.7 ± 2.9 kg/m2. The mean operation time was significantly shorter in the BS-PCNL group than in the P-PCNL group (80.2 ± 15.1 min vs. 92.4 ± 22.7 min and p = 0.01). There was no significant difference between the two groups in terms of fluoroscopy time, intraoperative complications, postoperative complications, and stone-free rates.Conclusion Our study shows that BS-PCNL is an effective and safe method that significantly reduces the operation time and should be considered as one of the primary treatment options for patients scheduled for PCNL.     

Antibody Response of Restricted Isotype to Heat Shock Proteins in Juvenile Chronic Arthritis

Synovial fluid and peripheral blood mononuclear cells from juvenile chronic arthritis (JCA) patients have previously been shown to exhibit substantial proliferative responses to both human and mycobacterial heat shock protein (hsp) 65. We investigated the nature of the antibody response to mycobacterial and E. coli hsp 65 and human and E. coli hsp 70 in 56 JCA patients using an ELISA. Elevated levels of antibodies to both human and E. coli hsp 70 were demonstrated. With hsp 65, raised levels of antibodies to the mycobacterial but not the E. coli protein were detected. Overall, 48% of patient serum samples contained antibodies of at least one isotype to mycobacterial hsp 65. These antibodies were predominantly of IgG and IgM isotype, a finding in contrast to adult rheumatoid arthritis, where IgA and IgG isotypes are most often detected.     

非胰岛素依赖型糖尿病患者脂蛋白(a)的变化及其与糖尿病肾病的关系

非胰岛素依赖型糖尿病患者脂蛋白（ａ）的变化及其与糖尿病肾病的关系杨正刚王战建王秀芬冯忠军刘宽芝我们以病例对照研究方式观察了非胰岛素依赖型糖尿病（ＮＩＤＤＭ）患者脂蛋白（ａ）［Ｌｐ（ａ）］的变化，并探讨与糖尿病肾病的关系。一、对象和方法１．对象：ＮＩＤ...     

EFFECTS OF 2-GUANIDINE-4-METHYLQUINAZOLINE ON GASTRIC ACID SECRETION IN RATS

In this study 2-guanidine-4-methylquinazoline (2-GMQ) appeared to decrease basal and stimulated gastric acid secretion, while structurally related compounds as dimethyl- biguanide, cyanoguanidine and 2-cyanoamino-4-methylpyrymidine did not. Thus, there is an antisecretory effect when the biguanide group is associated with a lipophilic structure. The antisecretive effects exerted by 2-GMQ are associated with anti H₂-histamine activity.The anti H₂-histamine nature of the effects of 2-GMQ was confirmed by the capacity of this compound of depressing the chronotropic activity of the isolated guinea pig auricle increased by histamine, as well as relaxant activity in rat uterus contracted by histamine, since both preparations are rich in H₂-histamine receptors.     

正常人腰椎间盘的MRI测量及其临床意义

目的:为国人开展腰椎间盘人工髓核假体(prostheticdicsnucleus,PDN)置换术提供影像解剖学资料。方法:对56例正常人的腰椎间盘(男44例,女12例)MRIT2加权像中髓核矢状径、横径,椎间隙前、中、后高度进行了测量。所选PDN假体为目前统一规格:前后径为12mm,高度分别为5mm、7mm、9mm。结果:髓核矢状径、横径及椎间隙高度均数之间无明显性别差异(P>0.05)。髓核矢状径均大于12mm,但大于24mm在L2/3中为23.2%,L3/4中21.4%,L4/5中21.4%,L5/S1中16.1%。椎间隙后高较低,5mm~9mm者在L2/3中为85.7%,L3/4中82.1%,L4/5中82.1%,L5/S1中58.9%,大于9mm者L2/3中0%,L3/4中1.8%,L4/5中1.8%,L5/S1中3.6%。结论:国人中大多数人腰椎间盘内仅可容纳单枚PDN假体,适合高度为5mm或7mm,可因人而异选择。     

牙周炎患者基础治疗前后牙周袋内挥发性硫化物水平的变化

目的 :了解牙周炎患者治疗前后牙周袋内挥发性硫化物水平的变化。方法 :对 8例牙周炎患者的 5 1颗牙进行牙周基础治疗 ,并于治疗前及治疗后 4周用金刚牙科探针记录颊侧近远中牙周袋内共 10 2个位点的挥发性硫化物 (volatilesulfurcompounds,VSC )水平及菌斑指数 (plaqueindex ,PI)、牙周探诊深度 (probingdepth ,PD )、出血指数(bleedingindex ,BI )及临床附着水平 (clinicalattachmentlevel ,CAL )。结果 :牙周基础治疗后 4周 ,牙周袋内VSC水平及牙周各项临床指标均明显下降 (P <0 .0 0 1)。结论 :牙周袋内VSC可能是反映牙周组织状况的一项较为客观的指标。     

回肠代膀胱扩大术治疗氯胺酮导致膀胱挛缩患者围手术期的护理

目的探讨回肠代膀胱扩大术治疗氯胺酮导致膀胱挛缩患者围手术期的护理要点。方法选取行回肠代膀胱扩大术治疗的因服用氯胺酮导致膀胱挛缩的患者6例,从术前、术后、并发症的处理及出院指导4个方面总结该类患者的护理要点。结果患者均手术顺利,肝肾功能恢复正常,经过精心护理,患者均治愈出院,临床疗效满意。结论回肠代膀胱扩大术是治疗氯胺酮导致膀胱挛缩的有效手段,精心的护理是患者手术成功及术后恢复的必要手段。     

浙江省嘉兴市成人麻疹抗体水平及影响因素调查

目的了解浙江省嘉兴市15岁以上健康成人麻疹保护性抗体水平,为制定成人麻疹防控策略提供科学数据。方法采用分层随机抽样的方法,采集嘉兴市15～74岁之间的569名健康成人血清,采用间接酶联免疫法（ELISA）定量检测麻疹IgG抗体。结果嘉兴市15岁以上健康成人麻疹IgG抗体阳性率为94.38%,保护率为54.31%,麻疹IgG抗体GMC为999.24IU/L。其中20～岁年龄组保护率最低,为45.92%,50～岁年龄组保护率最高,为71.64%,各年龄组麻疹抗体保护率差异有统计学意义（χ^2=14.84,P=0.038）,本地人口麻疹抗体保护率为50.94%,外地人口麻疹抗体保护率为57.24%,不同户籍与麻疹抗体保护率差异无统计学意义（χ^2=2.26,P=0.152）。结论嘉兴市15岁以上成人麻疹保护性抗体水平总体较低,建议做好初三学生麻风疫苗的常规接种,同时提高育龄妇女体内麻疹保护性抗体水平。