全文获取类型
收费全文 | 894篇 |
免费 | 105篇 |
专业分类
耳鼻咽喉 | 20篇 |
儿科学 | 51篇 |
妇产科学 | 13篇 |
基础医学 | 104篇 |
口腔科学 | 44篇 |
临床医学 | 78篇 |
内科学 | 198篇 |
皮肤病学 | 9篇 |
神经病学 | 58篇 |
特种医学 | 11篇 |
外科学 | 184篇 |
综合类 | 13篇 |
预防医学 | 35篇 |
眼科学 | 26篇 |
药学 | 88篇 |
中国医学 | 6篇 |
肿瘤学 | 61篇 |
出版年
2024年 | 1篇 |
2023年 | 6篇 |
2022年 | 18篇 |
2021年 | 32篇 |
2020年 | 16篇 |
2019年 | 27篇 |
2018年 | 28篇 |
2017年 | 25篇 |
2016年 | 31篇 |
2015年 | 31篇 |
2014年 | 46篇 |
2013年 | 46篇 |
2012年 | 90篇 |
2011年 | 113篇 |
2010年 | 38篇 |
2009年 | 17篇 |
2008年 | 40篇 |
2007年 | 33篇 |
2006年 | 44篇 |
2005年 | 34篇 |
2004年 | 35篇 |
2003年 | 39篇 |
2002年 | 25篇 |
2001年 | 17篇 |
2000年 | 20篇 |
1999年 | 18篇 |
1998年 | 10篇 |
1997年 | 13篇 |
1996年 | 8篇 |
1995年 | 2篇 |
1994年 | 6篇 |
1993年 | 17篇 |
1992年 | 21篇 |
1991年 | 6篇 |
1990年 | 1篇 |
1989年 | 4篇 |
1988年 | 2篇 |
1987年 | 4篇 |
1986年 | 6篇 |
1985年 | 4篇 |
1984年 | 4篇 |
1983年 | 4篇 |
1982年 | 3篇 |
1980年 | 1篇 |
1979年 | 7篇 |
1978年 | 4篇 |
1976年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有999条查询结果,搜索用时 31 毫秒
21.
22.
Al-Zakwani I Ali A Zubaid M Panduranga P Sulaiman K Abusham A Almahmeed W Al-Motarreb A Al Suwaidi J Amin H 《Journal of thrombosis and thrombolysis》2012,33(3):280-286
Little is known about the impact of thrombolytic agents on in-hospital outcomes in the Middle East. The objective of this
study was to evaluate the impact of thrombolytic agents on in-hospital outcomes in ST-segment elevation myocardial infarction
(STEMI) patients in six Middle Eastern countries. Gulf Registry of Acute Coronary Events was a prospective, multinational,
multicentre, observational survey of consecutive acute coronary syndrome patients admitted to 65 hospitals in 2006 and 2007.
Out of 1,765 STEMI patients admitted to hospitals within 12 h of symptoms onset, 25, 43, and 30% were treated with streptokinase,
reteplase, and tenecteplase, respectively. Median age of the study cohort was 50 (45–59) years and majority were males (89%).
The overall median symptom onset-to-presentation and median door-to-needle times were 130 min (65–240) and 45 min (30–75),
respectively. Streptokinase patients had worse GRACE risk scores compared to patients who received fibrin specific thrombolytics.
Academic hospitals and cardiologists as admitting physicians were associated with the use of fibrin specific thrombolytics.
After significant covariate adjustment, both reteplase [odds ratio (OR), 0.38; 95% CI: 0.18–0.79; P = 0.009] and tenecteplase (OR, 0.30; 95% CI: 0.12–0.77; P = 0.012) were associated with lower all-cause in-hospital mortality compared with streptokinase. No significant differences
in other in-hospital outcomes were noted between the thrombolytic agents. In conclusion, in light of the study’s limitations,
fibrin specific agents, reteplase and tenecteplase, were associated with lower all-cause in-hospital mortality compared to
the non-specific fibrin agent, streptokinase. However, the type of thrombolytic agent used did not influence other in-hospital
outcomes. 相似文献
23.
24.
Santosh B. Kurbet Gowda P. Prashanth Mahantesh V. Patil Shivaji Mane 《Indian Journal of Plastic Surgery》2013,46(3):549-554
Objective:
To study the problems faced during the surgery and follow-up of modified complete primary repair of exstrophy (CPRE) technique. Initial experience with CPRE and its short- and long-term outcomes with respect to continence status and psychosocial impact are reported.Materials and Methods:
A retrospective review of the hospital case records from March 2008 to September 2012 was performed. Data of patients with bladder exstrophy managed by a single paediatric surgeon using modified CPRE technique were analysed. Quality of life and psychosocial impact of the surgery were assessed using Pediatric Quality of Life Inventory (PedsQL 4.0) and compared with those of typical peers.Results:
Eight children (age 4 days-12 years) underwent CPRE using modified Mitchell''s technique. Two patients (25%) experienced early postoperative complications, with infection and fistula developing in one each. All the patients were doing well on follow-up, with variable continence rates and good cosmesis. Mean duration of follow-up was 18.5 months (range 6 months-4 years). Five out of seven (71%) children were continent or partially continent. One case was lost to follow-up. PedsQL scores were comparable with those of age-matched peers in all domains except the social functioning domain in 8-12 years age group (83.53 ± 9.70 vs. 77.86 ± 10.22, P < 0.05).Conclusion:
Our preliminary results with modified CPRE in neonates and children have been encouraging. No major complications were observed. Continence rate was satisfactory and cosmetic results were good. Though the technique is being practiced at several Indian centres, there is a paucity of comprehensive Indian data on CPRE.KEY WORDS: Bladder exstrophy, complete primary repair, urinary continence 相似文献25.
Sarah A Howles Mark H Edwards Cyrus Cooper Rajesh V Thakker 《Journal of bone and mineral research》2013,28(12):2535-2539
Kidney stones are common, with a multifactorial etiology involving dietary, environmental, and genetic factors. In addition, patients with nephrolithiasis are at greater risk of hypertension, diabetes mellitus, metabolic syndrome, and osteoporosis, although the basis for this is not fully understood. All of these renal stone–associated conditions have also been linked with adverse early‐life events, including low–birth weight, and it has been suggested that this developmental effect is due to excess exposure to maternal glucocorticoids in utero. This is proposed to result in long‐term increased hypothalamic‐pituitary‐axis activation; there are mechanisms through which this effect could also promote urinary lithogenic potential. We therefore hypothesize that the association between renal stone disease and hypertension, diabetes mellitus, metabolic syndrome, and osteoporosis may be related by a common pathway of programming in early life, which, if validated, would implicate the developmental origins hypothesis in the etiology of nephrolithiasis. © 2013 American Society for Bone and Mineral Research. 相似文献
26.
27.
A. Karunaratne A. Boyde C.T. Esapa J. Hiller N.J. Terrill S.D.M. Brown R.D. Cox R.V. Thakker H.S. Gupta 《BONE》2013,52(2):689-698
In metabolic bone diseases, the alterations in fibrillar level bone-material quality affecting macroscopic mechanical competence are not well-understood quantitatively. Here, we quantify the fibrillar level deformation in cantilever bending in a mouse model for hereditary rickets (Hpr). Microfocus in-situ synchrotron small-angle X-ray scattering (SAXS) combined with cantilever bending was used to resolve nanoscale fibril strain in tensile- and compressive tissue regions separately, with quantitative backscattered scanning electron microscopy used to measure microscale mineralization. Tissue-level flexural moduli for Hpr mice were significantly (p < 0.01) smaller compared to wild-type (~ 5 to 10-fold reduction). At the fibrillar level, the fibril moduli within the tensile and compressive zones were significantly (p < 0.05) lower by ~ 3- to 5-fold in Hpr mice compared to wild-type mice. Hpr mice have a lower mineral content (24.2 ± 2.1 Ca wt.% versus 27.4 ± 3.3 Ca wt.%) and its distribution was more heterogeneous compared to wild-type animals. However, the average effective fibril modulus did not differ significantly (p > 0.05) over ages (4, 7 and 10 weeks) between tensile and compressive zones. Our results indicate that incompletely mineralized fibrils in Hpr mice have greater deformability and lower moduli in both compression and tension, and those compressive and tensile zones have similar moduli at the fibrillar level. 相似文献
28.
Metta Vinod Leta Valentina Mrudula Kandadai Rukmini Prashanth L. K. Goyal Vinay Borgohain Rupam Chung-Faye Guy Chaudhuri K. Ray 《Journal of neurology》2022,269(3):1154-1163
Journal of Neurology - Gastrointestinal symptoms and gut dysbiosis may occur before the onset of motor symptoms in Parkinson's disease (PD). Prediagnostic and prodromal features, such as... 相似文献
29.
30.
Saket Singh MS MCh Julia F. Chen MD Roland Assi MD Naiem Nassiri MD Prashanth Vallabhajosyula MD MS 《Journal of cardiac surgery》2020,35(12):3578-3580
We report an emergent complex hybrid repair of a type A intramural hematoma with a tear of the aortic arch at the site of Kommerell's diverticulum and an aberrant right subclavian artery. We identified a type IA endoleak intraoperatively, which was managed immediately with proximal extension. Performing this operation in the hybrid operating room facilitated optimal surgical management. 相似文献