全文获取类型
收费全文 | 3234篇 |
免费 | 159篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 201篇 |
妇产科学 | 57篇 |
基础医学 | 382篇 |
口腔科学 | 37篇 |
临床医学 | 176篇 |
内科学 | 763篇 |
皮肤病学 | 55篇 |
神经病学 | 293篇 |
特种医学 | 77篇 |
外科学 | 378篇 |
综合类 | 137篇 |
一般理论 | 1篇 |
预防医学 | 258篇 |
眼科学 | 64篇 |
药学 | 316篇 |
中国医学 | 7篇 |
肿瘤学 | 187篇 |
出版年
2022年 | 25篇 |
2021年 | 80篇 |
2020年 | 47篇 |
2019年 | 46篇 |
2018年 | 71篇 |
2017年 | 54篇 |
2016年 | 54篇 |
2015年 | 41篇 |
2014年 | 65篇 |
2013年 | 119篇 |
2012年 | 145篇 |
2011年 | 184篇 |
2010年 | 107篇 |
2009年 | 122篇 |
2008年 | 170篇 |
2007年 | 126篇 |
2006年 | 124篇 |
2005年 | 112篇 |
2004年 | 122篇 |
2003年 | 108篇 |
2002年 | 84篇 |
2001年 | 84篇 |
2000年 | 83篇 |
1999年 | 84篇 |
1998年 | 43篇 |
1997年 | 27篇 |
1996年 | 34篇 |
1995年 | 18篇 |
1994年 | 26篇 |
1992年 | 53篇 |
1991年 | 51篇 |
1990年 | 60篇 |
1989年 | 74篇 |
1988年 | 65篇 |
1987年 | 58篇 |
1986年 | 43篇 |
1985年 | 55篇 |
1984年 | 40篇 |
1983年 | 40篇 |
1981年 | 18篇 |
1980年 | 24篇 |
1979年 | 35篇 |
1978年 | 22篇 |
1977年 | 26篇 |
1976年 | 24篇 |
1975年 | 27篇 |
1974年 | 26篇 |
1973年 | 32篇 |
1972年 | 26篇 |
1971年 | 20篇 |
排序方式: 共有3408条查询结果,搜索用时 31 毫秒
41.
42.
43.
M I Colado E O'Shea R Granados A Misra T K Murray A R Green 《British journal of pharmacology》1997,121(4):827-833
- It is well established that 3,4-methylenedioxymethamphetamine (MDMA or ‘ecstasy'') is neurotoxic and produces long term degeneration of cerebral 5-hydroxytryptamine (5-HT) nerve terminals in many species. Since MDMA is used extensively as a recreational drug by young people, it is being ingested by many women of child bearing age. We have therefore examined the effect of administering high doses of MDMA to rats during pregnancy on the cerebral content of both the dams and the neonates.
- MDMA (20 mg kg−1, s.c.) was injected twice daily on days 14–17 of the gestation period. The initial dose produced a marked hyperthermic response in the dam which was progressively attenuated in both peak height and area under the curve following further doses of the drug. The body weight of the dams decreased during the period of treatment.
- There was a modest decrease in litter size (−20%) of the MDMA-treated dams.
- The concentration of 5-HT and its metabolite 5-HIAA was decreased by over 65% in the hippocampus and striatum and 40% in the cortex of the dams 1 week after parturition. In contrast, the content of 5-HT and 5-HIAA in the dorsal telencephalon of the pups of the MDMA-treated dams was the same as that seen in tissue from pups born to control animals.
- Administration of MDMA (40 mg kg−1, s.c.) to adult rats increased thiobarbituric acid reacting substances (TBARS) in cortical tissue 3 h and 6 h later, indicating increased lipid peroxidation. No increase in TBARS was seen in the cortical tissue of 7–10 day neonates injected with this dose of MDMA 3 h or 6 h earlier.
- The data suggest that exposure to MDMA in utero during the maturation phase does not produce damage to 5-HT nerve terminals in the foetal rat brain, in contrast to the damage seen in the brains of the mothers. This may be due to MDMA being metabolized to free radical producing entities in the adult brain but not in the immature brain or, alternatively, to more effective or more active free radical scavenging mechanisms being present in the immature brain.
44.
Lazarus MD Chansky HA Misra S Williams GR Iannotti JP 《Journal of shoulder and elbow surgery / American Shoulder and Elbow Surgeons ... [et al.]》1994,3(1):1-11
We retrospectively reviewed 68 patients (70 shoulders) who underwent either open or arthroscopic acromioplasty performed by a single surgeon (JPI) for chronic impingement syndrome in the presence of an intact rotator cuff. Group 1 consisted of 24 shoulders that had open acromioplasty and group 2 consisted of 46 shoulders that had arthroscopic acromioplasty. The minimum follow-up was 12 months for both groups. There was no statistical difference in mean postoperative shoulder scores between the operative groups. However, there were more excellent results in the open group as compared with the arthroscopic group (54.2% vs 41.9%, respectively). In addition, there was a higher percentage of poor results in group 2 as compared with group 1 (27.9% vs 16.6%, respectively). Arthroscopic acromioplasty was associated with shorter hospital stays and faster achievement of maximal pain relief as compared with open acromioplasty. Examination of postoperative radiographs often revealed subacromial calcifications. These calcifications were more frequent after arthroscopic acromioplasty and were associated with a worse result. 相似文献
45.
46.
Chakrabarti R Vikramadithyan RK Dileepkumar T Kumar KB Kumar MP Misra P Rao PB Lohray VB Lohray BB Rajagopalan R 《Arzneimittel-Forschung》1999,49(11):905-911
Euglycemic and hypolipidemic activities of a novel indole analogue of thiazolidinedione, DRF 2189 (CAS 172647-53-9), have been evaluated in different animal models. Compared to troglitazone (CAS 97322-87-7), DRF 2189 exhibited interesting plasma glucose and triglyceride lowering activity in genetically diabetic and obese db/db mice. It also produced a significant reduction in plasma glucose, triglyceride, total cholesterol levels and improvement in oral glucose tolerance in another genetic mouse model, the ob/ob mice. In high-fat diet fed Sprague-Dawley rats, DRF 2189 treatment showed improvement in plasma lipid parameters. Like other thiazolidinediones, this compound also possesses peroxisome proliferator activated receptor gamma (PPAR gamma) transactivation potential. In anaesthetized rat experiment, DRF 2189 produced a transient fall in blood pressure without any change in the ECG pattern. It showed non-specific smooth muscle relaxant activity against acetylcholine, histamine and potassium chloride induced contractions in isolated guinea pig ileum. A twenty-eight-day toxicity study in Wistar rats did not show any signs of treatment related adverse effects. The overall antidiabetic and hypolipidemic activities of DRF 2189 are comparable with rosiglitazone (CAS 155141-29-0) and superior to troglitazone. In conclusion, results from these preclinical studies indicate that DRF 2189, a novel thiazolidinedione, has a marked potential for the management of type-2 diabetes. 相似文献
47.
A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066 总被引:7,自引:0,他引:7
Snape MF Misra A Murray TK De Souza RJ Williams JL Cross AJ Green AR 《Neuropharmacology》1999,38(1):181-193
The in vitro and in vivo effects of the novel acetylcholinesterase inhibitors donepezil and NXX-066 have been compared to tacrine. Using purified acetylcholinesterase from electric eel both tacrine and donepezil were shown to be reversible mixed type inhibitors, binding to a similar site on the enzyme. In contrast, NXX-066 was an irreversible non-competitive inhibitor. All three compounds were potent inhibitors of rat brain acetylcholinesterase (IC50 [nM]; tacrine: 125 +/- 23; NXX-066: 148 +/- 15; donepezil: 33 +/- 12). Tacrine was also a potent butyrylcholinesterase inhibitor. Donepezil and tacrine displaced [3H]pirenzepine binding in rat brain homogenates (IC50 values [microM]; tacrine: 0.7; donepezil: 0.5) but NXX-066 was around 80 times less potent at this M1-muscarinic site. Studies of carbachol stimulated increases in [Ca2+]i in neuroblastoma cells demonstrated that both donepezil and tacrine were M1 antagonists. Ligand binding suggested little activity of likely pharmacological significance with any of the drugs at other neurotransmitter sites. Intraperitoneal administration of the compounds to rats produced dose dependent increases in salivation and tremor (ED50 [micromol/kg]; tacrine: 15, NXX-066: 35, donepezil: 6) with NXX-066 having the most sustained effect on tremor. Following oral administration, NXX-066 had the slowest onset but the greatest duration of action. The relative potency also changed, tacrine having low potency (ED50 [micromol/kg]; tacrine: 200, NXX-066: 30, donepezil: 50). Salivation was severe only in tacrine treated animals. Using in vivo microdialysis in cerebral cortex, both NXX-066 and tacrine were found to produce a marked (at least 30-fold) increase in extracellular acetylcholine which remained elevated for more than 2 h after tacrine and 4 h after NXX-066. 相似文献
48.
K A Reddy B B Lohray V Bhushan A S Reddy N V Rao Mamidi P P Reddy V Saibaba N J Reddy A Suryaprakash P Misra R K Vikramadithyan R Rajagopalan 《Journal of medicinal chemistry》1999,42(17):3265-3278
Several thiazolidinediones having chroman moieties were synthesized and evaluated for their euglycemic and hypolipidemic activities. Some of the analogues having an aminoalkyl group as a linker between the chroman ring and 4-[5-(2,4-dioxo-1, 3-thiazolidinyl)methyl]phenoxy moiety seem to be better than troglitazone. In vitro transactivation assays of PPARgamma have been carried out with these glitazones to understand their molecular mechanism. For the first time we have found that some of the unsaturated thiazolidinediones are superior to their saturated counterpart in the in vivo assay. A more potent thiazolidinedione analogue than troglitazone is reported. Pharmacokinetic studies have shown that protection of the OH group in the chroman moiety leads to a decrease in metabolism, thereby resulting in a superior pharmacological profile. 相似文献
49.
A novel topical clofazimine (CLO) gel formulation containing liposomally encapsulated CLO, was prepared and investigated in vitro followed by a clinical evaluation. CLO liposomes were prepared by the lipid film hydration technique. Comparative in vitro diffusion studies were conducted with plain and liposomal CLO in HPMC K4M gel base (2% and 5%) using human cadaver skin (HCS). A double blind clinical study was conducted on eight leprosy patients. The results of these studies show that the new liposomal topical gel formulation not only prolongs the drug release but also promotes drug retention by the skin. Studies further support formation of a reservoir of drug on the skin modifying therapeutic efficacy of the formulation. The new liposomal gel formulation of CLO considerably reduces the healing time of external lesions due to a significantly prolonged skin residence time compared to plain CLO gel and hence is expected to reduce the time needed for leprosy treatment. 相似文献
50.
The nature of gene action for biomass yield and tropane alkaloid content was ascertained through diallel analysis in Egyptian henbane, HYOSCYAMUS MUTICUS L. Dominance variation was preponderant over additive genetic variance, dominance being in the overdominance range for both traits. On an overall basis, recessive alleles had a positive (i.e. increasing) effect on both the characters. However, the positive or negative effects of recessive or dominant alleles were genotype-specific. Hence, transgressive breeding was suggested for isolating segregants with dominant alleles for herb yield and with recessives for alkaloid content so as to achieve overall high yields of tropane alkaloid per unit area. 相似文献