全文获取类型
收费全文 | 1280篇 |
免费 | 123篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 23篇 |
妇产科学 | 27篇 |
基础医学 | 158篇 |
口腔科学 | 6篇 |
临床医学 | 156篇 |
内科学 | 286篇 |
皮肤病学 | 9篇 |
神经病学 | 153篇 |
特种医学 | 43篇 |
外科学 | 85篇 |
综合类 | 17篇 |
一般理论 | 1篇 |
预防医学 | 199篇 |
眼科学 | 28篇 |
药学 | 163篇 |
中国医学 | 3篇 |
肿瘤学 | 45篇 |
出版年
2024年 | 1篇 |
2023年 | 16篇 |
2022年 | 43篇 |
2021年 | 56篇 |
2020年 | 38篇 |
2019年 | 66篇 |
2018年 | 57篇 |
2017年 | 43篇 |
2016年 | 59篇 |
2015年 | 41篇 |
2014年 | 51篇 |
2013年 | 62篇 |
2012年 | 80篇 |
2011年 | 120篇 |
2010年 | 64篇 |
2009年 | 59篇 |
2008年 | 114篇 |
2007年 | 89篇 |
2006年 | 71篇 |
2005年 | 72篇 |
2004年 | 45篇 |
2003年 | 42篇 |
2002年 | 41篇 |
2001年 | 13篇 |
2000年 | 10篇 |
1999年 | 5篇 |
1998年 | 6篇 |
1996年 | 2篇 |
1995年 | 3篇 |
1994年 | 4篇 |
1993年 | 2篇 |
1992年 | 5篇 |
1991年 | 3篇 |
1990年 | 4篇 |
1988年 | 2篇 |
1984年 | 4篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1968年 | 2篇 |
1967年 | 1篇 |
1963年 | 1篇 |
1958年 | 1篇 |
1956年 | 2篇 |
1954年 | 1篇 |
1948年 | 2篇 |
1945年 | 1篇 |
排序方式: 共有1407条查询结果,搜索用时 15 毫秒
31.
There is currently no structured system for nurses or allied health professionals to undertake further training to become a nurse specialist (NSp) or nurse practitioner (NP) in rheumatology on-site, while working in a district general hospital setting. These shortcomings have prompted us to develop a structured pathway that could be followed by staff nurses who wish to become NSp in rheumatology. The proposed pathway aims to assist the nurses or therapists (physiotherapists, psychologists, occupational therapist, podiatrists, etc.) to develop a sound knowledge based on the rationale, safety, and high quality clinical care when monitoring of patients taking disease-modifying anti-rheumatic drugs (DMARDs) to ensure they acquire skills enabling them to provide safe, evidence-based effective patient-centered care. Near the end of the pathway, the trainee would be expected to have an understanding of the particularities of chronic arthritis conditions as well as screening, assessment, and monitoring of patients receiving DMARDs and biological agents. Tests for competencies are included and certification may be considered. 相似文献
32.
Erin Rothwell Rebecca A. Anderson Kathryn J. Swoboda Louisa Stark Jeffrey R. Botkin 《American journal of medical genetics. Part A》2013,161(4):679-686
A population‐based pilot study of newborns screening for a rare genetic condition, spinal muscular atrophy (SMA), is being conducted with funding from the National Institutes of Health. The first component of the study is to assess the ethical, legal, and social implications of population‐based pilot studies with a focus on public engagement and parental decision‐making for the proposed opt‐out approach in this research. We conducted focus groups with members of the general public to ascertain attitudes about the pilot study and acceptability of an opt‐out approach in two states, Colorado and Utah, where the pilot screening is being proposed (N = 70). We developed an informational video for the project and showed it to the groups prior to the discussion in order to inform participants about population‐based research, newborn screening (NBS), permission/consent models, and SMA. Results indicated support for the conduct of pilot studies that is consistent with the current standard of practice for similar population‐based programs. There was support for an opt‐out approach for parental decision‐making; however there was limited parental knowledge about population‐based research, NBS and SMA. In general, our participants considered this pilot study to be low risk and of potential benefit to infants and families. The majority of participants were supportive of an opt‐out approach with information delivered through various avenues © 2013 Wiley Periodicals, Inc. 相似文献
33.
Dov Goldvasser MSc Anthony Marchie Louisa K. BragdonCharles R. Bragdon PhD Lars Weidenhielm Henrik Malchau 《The Journal of arthroplasty》2013
Detection of polyethylene wear and osteolysis in total knee arthroplasty using radiographs is imprecise. To correlate radiographic findings with retrieved tibial component analysis, we reviewed knee revision cases. A joint registry was used to identify all knee revisions. Radiographic scoring systems were developed. Radiographs were analyzed for osteolysis and implant alignment. Polyethylene liner retrievals were visually and optically graded for surface damage. Statistical analyses that included correlation analysis and Mann-Whitney U test were used. When osteolysis was found, radiographic scores and delamination score were significantly higher (P = .047 and P = .014, respectively). Delamination is a good indicator for polyethylene wear and osteolysis. There is a need to develop in vivo methods to identify polyethylene changes and thereby prevent severe clinical outcomes. 相似文献
34.
Jonathan P. Stange Louisa G. Sylvia Pedro Vieira da Silva Magalhães Ellen Frank Michael W. Otto David J. Miklowitz Michael Berk Andrew A. Nierenberg Thilo Deckersbach 《Journal of psychiatric research》2013
Background
Relatively little is known about psychological predictors of the onset of mania among individuals with bipolar disorder, particularly during episodes of depression. In the present study we investigated attributional style as a predictor of onset of hypomanic, manic or mixed episodes among bipolar adults receiving psychosocial treatment for depression. We hypothesized that “extreme” (i.e., excessively pessimistic or optimistic) attributions would predict a greater likelihood of developing an episode of mood elevation.Method
Outpatients with DSM-IV bipolar I or II disorder (N = 105) enrolled in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) were randomly allocated to one of three types of intensive psychotherapy for depression or a brief psychoeducational intervention. Patients completed a measure of attributional style at baseline and were followed prospectively for up to one year. All analyses were by intent to treat.Results
Logistic regressions and Cox proportional hazards models indicated that extreme (both positively- and negatively-valenced) attributions predicted a higher likelihood of (and shorter time until) transition from depression to a (hypo)manic or mixed episode (ps < .04), independent of the effects of manic or depressive symptom severity at baseline. Extreme attributions were also retrospectively associated with more lifetime episodes of (hypo)mania and depression (ps < .05).Conclusions
Evaluating extreme attributions may help clinicians to identify patients who are at risk for experiencing a more severe course of bipolar illness, and who may benefit from treatments that introduce greater cognitive flexibility. 相似文献35.
Klein Anke Krebs Oliver Gehl Axel Morgner Judith Reeger Louisa Augustin Christa Edler Carolin 《International journal of legal medicine》2019,133(5):1567-1574
International Journal of Legal Medicine - In cases of crimes involving blood, the perpetrators often attempt to remove the traces they have left behind. Setting fire to the crime scene, aside from... 相似文献
36.
Thomas Louisa Lockwood Patricia L. Garvert Mona M. Balsters Joshua H. 《Journal of autism and developmental disorders》2022,52(2):700-713
Journal of Autism and Developmental Disorders - Neuroeconomics paradigms have demonstrated that learning about another’s beliefs can make you more like them (i.e., contagion). Due to social... 相似文献
37.
Morgane Linard MD PhD Alix Ravier MD Louisa Mougué MD Iris Grgurina MSc Anne-Laurence Boutillier PhD Alexandra Foubert-Samier MD PhD Frédéric Blanc MD PhD Catherine Helmer MD PhD 《Movement disorders》2022,37(3):464-477
α-synucleinopathies, encompassing Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy, are devastating neurodegenerative diseases for which available therapeutic options are scarce, mostly because of our limited understanding of their pathophysiology. Although these pathologies are attributed to an intracellular accumulation of the α-synuclein protein in the nervous system with subsequent neuronal loss, the trigger(s) of this accumulation is/are not clearly identified. Among the existing hypotheses, interest in the hypothesis advocating the involvement of infectious agents in the onset of these diseases is renewed. In this article, we aimed to review the ongoing relevant factors favoring and opposing this hypothesis, focusing on (1) the potential antimicrobial role of α-synuclein, (2) potential entry points of pathogens in regard to early symptoms of diverse α-synucleinopathies, (3) pre-existing literature reviews assessing potential associations between infectious agents and Parkinson's disease, (4) original studies assessing these associations for dementia with Lewy bodies and multiple system atrophy (identified through a systematic literature review), and finally (5) potential susceptibility factors modulating the effects of infectious agents on the nervous system. © 2022 International Parkinson and Movement Disorder Society 相似文献
38.
Edwards L Ring C France CR al'Absi M McIntyre D Carroll D Martin U 《Biological psychology》2007,76(1-2):72-82
Supraspinal pain modulation may explain hypertensive hypoalgesia. We compared nociceptive flexion reflex (NFR) thresholds and pain during rest and computer game play in hypertensives and normotensives (Experiment 1) and normotensives with and without hypertensive parents (Experiment 2). The game was selected to modulate activity in pain pathways. NFR thresholds did not differ between groups during rest or game play. Pain ratings never differed between hypertensives and normotensives, whereas individuals with hypertensive parents reported less pain during the first two NFR assessments, compared to those without. NFR thresholds and pain were reduced by game play compared to rest. The failure of game play to differentially modulate NFR thresholds or associated pain reports between groups argues against enhanced supraspinal modulation of nociception and pain in hypertensives and those at increased risk for hypertension. 相似文献
39.
40.
Yuri P. Springer PhD Devin L. Lucas PhD Louisa J. Castrodale DVM MPH Joseph B. McLaughlin MD MPH 《American journal of industrial medicine》2018,61(1):32-41