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排序方式: 共有1165条查询结果,搜索用时 15 毫秒
991.
Amparo del Pino‐Gutiérrez PhD Fernando Fernández‐Aranda PhD Roser Granero PhD Salomé Tárrega PhD Ana Valdepérez MsC Zaida Agüera PhD Anders Håkansson MD PhD Anne Sauvaget MD PhD Neus Aymamí PhD Mónica Gómez‐Peña PhD Laura Moragas PhD Marta Baño MsC María Honrubia MsC José M. Menchón MD PhD Susana Jiménez‐Murcia PhD 《International journal of mental health nursing》2017,26(2):121-128
Similarities between gambling disorder and substance use disorders have been extensively described. To date, however, few studies using large clinical samples have been carried out that reliably assess the relationship between different levels of alcohol consumption and gambling disorders. The present study aimed to assess the impact of baseline alcohol consumption levels on the clinical profile in a large sample of treatment‐seeking individuals. Nine hundred and fifty‐one consecutive outpatients diagnosed with gambling disorder according to DSM‐IV criteria were compared after being included in three alcohol consumption groups (low risk, abuse and risk of dependence) based on their total raw scores on the AUDIT questionnaire. Results showed a high prevalence of risk of alcohol dependence in GD patients who were immigrants, unemployed, and had a low level of education. A positive linear trend was also found between alcohol consumption level and the prevalence of other current and life‐time comorbid mental disorders, and for the presence of drug abuse. Statistically significant differences were found between the three alcohol consumption groups in terms of the evolution and severity of the gambling disorder, self‐directedness personality trait, and levels of general psychopathology, hostility and paranoid ideation. In conclusion, the results showed an association between increased alcohol consumption and greater dysfunction. 相似文献
992.
Human pegivirus molecular epidemiology in Argentina: Potential contribution of Latin American migration to genotype 3 circulation
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993.
Monica Mazza Giuliana Lucci Francesca Pacitti Maria Chiara Pino Melania Mariano Massimo Casacchia 《Neuropsychological rehabilitation》2013,23(5):675-703
Schizophrenics display impairments in domains of social cognition such as theory of mind and emotion recognition. Recent studies, showing that the relationship of social cognition abilities with functional outcome is more significant than other neuro-cognitive functions, have considered these abilities as a target for intervention research. This article describes preliminary data from a new group-based study focused on Emotion and ToM Imitation Training (ETIT), an imitation treatment aimed at improving social cognition and social functioning in schizophrenia. In the present study, 16 outpatients with schizophrenia completed ETIT assessment and were compared with 17 outpatients who participated to a Problem Solving Training group. Participants were assessed at pre- and post-test on measures of emotion recognition, theory of mind, cognition, flexibility and social functioning. We compared the rehabilitation training effects on neuro-physiological activation through the event-related potentials (ERPs) method, which was recorded pre- and post-rehabilitation training. The results showed that when compared to the control group, ETIT participants improved on every social cognitive measure and showed better social functioning at post-test. Improvement in social cognition, in particular in emotion recognition, is also supported by ERP responses: we recorded an increase in electroactivity of medio-frontal areas only after ETIT treatment. Action observation and imitation could be regarded as a new frontier in rehabilitation. 相似文献
994.
995.
Amy White Adam Guenzel Coleman Turgeon Maria Escolar Dawn Peck Gisele Pino April Studinski George Hoganson Peter Baker Jennifer Rubin Alanna Strong Rachel Hickey Jennifer Burton Nicole Engelhardt Leighann Sremba Sharon Chen Martin Bialer Laura Pisani Dietrich Matern 《Molecular genetics and metabolism》2021
996.
997.
998.
P. Moriña M. Herrera J. Venegas D. Mora M. Rodríguez E. Pino 《Intensive care medicine》1997,23(1):58-64
Objective:
To determine whether nebulized salbutamol improves the respiratory mechanics of patients with adult respiratory distress syndrome
(ARDS). We also assessed the mechanisms that contribute to high respiratory system resistances during this disease.
Patients and setting:
Eleven consecutive patients with ARDS without clinical evidence of chronic obstructive pulmonary disease, admitted to a polivalent
intensive care unit, and mechanically ventilated with Siemens Elema Servo C ventilator at constant inspiratory flow.
Method:
Peak airway pressure (Ppeak), airway pressure immediately after end inspiratory occlusion (P1), plateau pressure (P2) and
intrinsic positive end-expiratory pressure (PEEPi) were measured at baseline condition and then 5, 15, and 30 min after 1 mg
of salbutamol had been administered via a nebulizer through the endotracheal tube. Partial pressure of arterial oxygen (PaO2), heart rate (HR) and mean blood pressure (BP) were monitored and minimal respiratory system resistances (Rrs, m), additional
resistances (DRrs) and static compliance (Cst) were computed
Results:
Between baseline and post-salbutamol, we observed changes in Ppeak, P1, P2, PEEPi and Rrs, m. As there were no significant
differences between values at the different intervals during post administration, the results are described comparing baseline
and 15 min post-salbutamol administration values. We found a significant decrease in Ppeak (4.9±0.8 cmH2O), P1 (3±0.6 cmH2O), P2 (2.1±0.6 cmH2O), PEEPi (1.9±0.5 cmH2O) and Rrs, m (1.9±0.3 cmH2O/1 s-1); DR, rs decreased in five patients, did not change in four and increased in two. HR, PaO2 and BP did not change.
Conclusions:
a) Salbutamol administered through the endotracheal tube by a nebulizer device lessens respiratory system resistances and
airway and alveolar pressures, and therefore could decrease the risk of barotrauma and alveolar damage; b) high respiratory
system resistances in ARDS have an increased smooth muscle tone component that can be reversible with salbutamol.
Received: 20 January 1995 Accepted: 15 September 1996 相似文献
999.
Buthionine sulfoximine increases the toxicity of nifurtimox and benznidazole to Trypanosoma cruzi
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Faundez M Pino L Letelier P Ortiz C López R Seguel C Ferreira J Pavani M Morello A Maya JD 《Antimicrobial agents and chemotherapy》2005,49(1):126-130
l-Buthionine (S,R)-sulfoximine (BSO) increased the toxicity of nifurtimox and benznidazole toward the epimastigote, trypomastigote, and amastigote forms of Trypanosoma cruzi. BSO at 500 muM decreased total glutathione-derived thiols by 70 to 80% in 48 h. In epimastigotes, 500 muM BSO decreased the concentration of nifurtimox needed to inhibit constant growth of the parasites by 50%, from 14.0 to 9.0 muM, and decreased that of benznidazole from 43.6 to 24.1 muM. The survival of epimastigotes or trypomastigotes treated with nifurtimox or benznidazole, as measured by MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) reduction, was significantly decreased by 500 muM BSO. In Vero cells infected with amastigotes, 25 muM BSO was able to potentiate the effect of nifurtimox and benznidazole as measured by the percentage of infected Vero cells multiplied by the average number of intracellular amastigotes (endocytic index). At 0.5 muM nifurtimox, the proportion of Vero cells infected decreased from 27 to 20% and the endocytic index decreased from 2,500 to 980 when 25 muM BSO was added. Similar results were obtained with benznidazole- and BSO-benznidazole-treated cells. This study indicates that potentiation of nifurtimox or benznidazole by BSO could decrease the clinical dose of both drugs and diminish the side effects or the length of therapy. 相似文献
1000.
Ana Boladeras Luigina Santorsa Cristina Gutierrez Evelyn Martinez Joan Pera Francisco Pino José Francisco Suarez Ferran Ferrer Aurora Díaz Alfredo Polo Ferran Guedea 《Radiotherapy and oncology》2014