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Pino Cidad Ana Boto Almudena Del Hierro Maria Capote Susana Noval Amanda Garcia Susana Santiago 《Korean journal of ophthalmology : KJO》2014,28(3):278-283
We studied three patients who developed left unilateral punctate keratitis after suffering left-sided Wallenberg Syndrome. A complex evolution occurred in two of them. In all cases, neurophysiological studies showed damage in the trigeminal sensory component at the bulbar level. Corneal involvement secondary to Wallenberg syndrome is a rare cause of unilateral superficial punctate keratitis. The loss of corneal sensitivity caused by trigeminal neuropathy leads to epithelial erosions that are frequently unobserved by the patient, resulting in a high risk of corneal-ulcer development with the possibility of superinfection. Neurophysiological studies can help to locate the anatomical level of damage at the ophthalmic branch of the trigeminal nerve, confirming the suspected etiology of stroke, and demonstrating that prior vascular involvement coincides with the location of trigeminal nerve damage. In some of these patients, oculofacial pain is a distinctive feature. 相似文献
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E. Roldán M. Gómez M.R. Pino J. Díaz 《International journal of environmental health research》2015,25(3):277-287
The aim of this study was to determine the temperature threshold that triggers an increase in heat-induced mortality in Zaragoza, Spain to determine the impact of extreme heat on mortality and in-hospital cost. A longitudinal ecological study was conducted according to an autoregressive integrated moving average model of a time series for daily deaths and to determine the relative risk of mortality for each degree that the temperature threshold was exceeded. Mortality showed a statistically significant increase when the daily maximum temperature exceeded 38?°C. A Relative Risk was 1.28 with a 95?% confidence interval (95?%CI:1.08–1.57) This threshold temperature didn’t change over time. A total of 107 (95?%CI:42–173) heat-attributable deaths were estimated for the period 2002–2006, and the in-hospital estimated cost of these deaths reach € 426,087(95?%CI.€167,249–€688,907). The articulation of preventive measures to minimize the impact of extreme heat on human health is necessary because of the mortality–temperature relationship. 相似文献
25.
Pino Cidad Eugenia González Mónica Asencio Jesús García 《Korean journal of ophthalmology : KJO》2015,29(5):331-335
PurposeTo study the retinal pigment epithelium (RPE) and retinal alterations in chronic central serous chorioretinopathy treated with photodynamic therapy, and its correlation with functional parameters such as best-corrected visual acuity (BCVA) and contrast sensitivity (CS).MethodsRetrospective, noncomparative, consecutive evaluation by optical coherence tomography and its correlation with BCVA and CS in 31 eyes of 26 patients.ResultsIn all affected patients, 88.5% were male with a mean age of 42.9 years. The right eye was involved in 64.5% of cases, bilateral in 19% and 73.9% were hyperopic (spherical refraction between 0 and +5.0 diopters). Of these cases, 51.5% had peri-RPE abnormalities, 17.3% hyperreflective substances at RPE, 19.4% RPE atrophy, 55.3% foveolar atrophy, 3.1% pigment epithelial detachment, 5.2% subretinal fluid persistence, 8.3% fibrin deposits, 68.4% photoreceptor inner and outer segment line interruption and 31.1% external limiting membrane interruption.ConclusionsTime evolution and number of outbreaks were related to the decrease in foveal and chorodial thickness and in those with worse BCVA and CS. RPE abnormalities and atrophy were related to the age of onset of symptoms. Photoreceptor elongation has been correlated with poor BCVA and inner and outer segment line destructuring and interruption with poor CS. 相似文献
26.
Effects of chronic iodine excess in a cohort of long-term American workers in West Africa 总被引:3,自引:0,他引:3
Pearce EN Gerber AR Gootnick DB Khan LK Li R Pino S Braverman LE 《The Journal of clinical endocrinology and metabolism》2002,87(12):5499-5502
A cross-sectional survey of 102 Peace Corps volunteers in Niger, West Africa, in 1998 had previously demonstrated a high rate of thyroid dysfunction and goiter attributable to excess iodine from their water filters. The Peace Corps volunteers were followed-up a mean of 30 wk after they ceased using iodine-based water filtration systems. Goiter was present in 44% of subjects during excess iodine ingestion and in 30% after removal of excess iodine. Mean serum iodine decreased from 293 micro g/liter during excess iodine ingestion to 84 micro g/liter after cessation of excess iodine. Mean total serum T(4) values increased from 100.4 to 113.3 nmol/liter (7.8 to 8.8 micro g/dl). Mean serum free T(4) increased from 32.2 to 34.7 pmol/liter (2.5 to 2.7 ng/dl). Mean serum TSH decreased from 4.9 to 1.8 mU/liter. Mean serum thyroid peroxidase antibody levels decreased from 33,000 to 22,000 IU/liter (33 to 22 IU/ml). We found that during prolonged excess iodine exposure there were marked increases in serum total iodine concentrations, and the prevalence of goiter, elevated serum TSH values, and elevated serum thyroid peroxidase antibody values increased. The prevalence of all abnormalities decreased after removal of excess iodine from the drinking water system. 相似文献
27.
R. Scicali A. Di Pino R. Platania G. Purrazzo V. Ferrara A. Giannone F. Urbano A. Filippello V. Rapisarda E. Farruggia S. Piro A.M. Rabuazzo F. Purrello 《Nutrition, metabolism, and cardiovascular diseases : NMCD》2018,28(1):35-43
Background and aims
Familial hypercholesterolemia (FH) is underdiagnosed and public cholesterol screening may be useful to find new subjects. In this study, we aim to investigate the prevalence of FH patients in a hospital screening program and evaluate their atherosclerotic burden using intima-media thickness (IMT).Methods and results
We screened 1575 lipid profiles and included for genetic analysis adults with a low-density lipoprotein (LDL) cholesterol >190 mg/dL and triglycerides <200 mg/dL and first-degree child relatives with LDL cholesterol >160 mg/dL and triglycerides <200 mg/dL. The diagnosis of FH was presumed by Dutch Lipid Clinic Network (DLCN) criteria and confirmed by the presence of the genetic variant. Mean common carotid intima-media thickness (IMT) was assessed using consensus criteria. After confirming LDL cholesterol value and excluding secondary hypercholesterolemia, 56 subjects with a DLCN ≥4 performed genetic analysis. Of these, 26 had an FH genetic variant. The proportion of patients with a mutation having a DLCN score of 6–8 was 75%; in individuals with a DLCN score >8 it was 100%. Mean IMT was higher in FH patients compared to non FH (0.73 [0.61–0.83] vs 0.71 [0.60–0.75] mm, p < 0.01). Moreover, we detected two mutations not previously described. Finally, simple regression analysis showed a correlation of IMT with LDL cholesterol >190 mg/dL and corneal arcus (p < 0.01 and p < 0.001, respectively).Conclusions
A hospital screening was useful to detect FH subjects with increased atherosclerosis. Also, next-generation sequencing was able to detect new FH mutations. 相似文献28.
Ane Murueta‐Goyena Rocío Del Pino Marta Galds Begoa Arana Marian Acera Mar Carmona‐Abelln Tamara Fernndez‐Valle Beatriz Tijero Olaia Lucas‐Jimnez Natalia Ojeda Naroa Ibarretxe‐Bilbao Javier Pea Jesus Cortes Unai Ayala Maitane Barrenechea Juan Carlos Gmez‐Esteban Iigo Gabilondo 《Annals of neurology》2021,89(1):165-176
29.
Dawn Peck Amy White Gisele Pino April Studinski Meghan Strenk Randi Gadea Jennifer Gannon Bryce Heese Esperanza Font-Montgomery Tracy Klug Jennifer Burton George Hoganson Devin Oglesbee Dimitar Gavrilov Dietrich Matern Kimiyo Raymond Piero Rinaldo Silvia Tortorelli 《Molecular genetics and metabolism》2021