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121.
Femia P González del Pino B Pérez-Fernández N 《Acta otorrinolaringologica espanola》2011,62(4):311-317
This is a review of the normal methods for vestibular examination, both clinical and instrumental, to evaluate the vestibular system. Emphasis is given to the examination sequence and objectives in each method. 相似文献
122.
Bermejo-Martin JF Tenorio A Ortiz de Lejarazu R Eiros JM Matías V Dominguez-Gil M Pino M Alonso A Blanco-Quiros A Arranz E Ardura J 《Intervirology》2008,51(2):112-115
Human respiratory syncytial virus (RSV) is the leading viral cause of severe respiratory illness in infants and young children worldwide. RSV isolates can be divided into 2 subgroups, type A and type B. Here, we compare for the first time the nasal profiles of 27 immune mediators in response to both viral subtypes in 14 children infected with RSV/A, 8 children infected with RSV/B, 11 children coinfected with RSV/A plus other respiratory viruses, and finally, 27 control children, all <2 years old. Our results evidence that children's infection with both RSV subtypes induces very similar profiles of immune mediators in the upper respiratory tract, characterized by the elevation of Th1 and Th2 cytokines, chemokines and growth factors. Interestingly, no major differences in the profiles of the immune mediators were found between the children infected exclusively with RSV/A and those infected with RSV/A plus other respiratory viruses. 相似文献
123.
Toxic epidermal necrolysis (TEN) is a severe mucocutaneous syndrome that can be occasionally caused by anticonvulsant drugs. In some cases, cranial irradiation may act as a precipitating factor. Thus, in cancer patients who suffer from brain metastases and are administered antiepileptic drugs for seizure prophylaxis, the risk of developing TEN after receiving palliative brain radiotherapy cannot be ignored. We is reported. The case of a young patient with non-small cell lung cancer (NSCLC) treated with prophylactic phenobarbital who developed TEN within a few days of completing cranial radiotherapy for brain metastases is reported. To minimize the risk of TEN in patients undergoing brain radiotherapy, prophylactic anticonvulsant therapy is recommended only after an accurate measurement of the true benefits. Alternatively, discontinuation of antiepileptic treatment before the initiation of brain radiotherapy, or the use of anticonvulsants associated with a lower risk of developing cutaneous reactions might be considered. 相似文献
124.
Fuelling the mechanisms of asthma: Increased fatty acid oxidation in inflammatory immune cells may represent a novel therapeutic target
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Eussen BH van de Laar I Douben H van Kempen L Hochstenbach R De Man SA Van Opstal D de Klein A Poddighe PJ 《European journal of medical genetics》2007,50(2):112-119
We describe a unique family with two children having a delay in psychomotor development. In both children we identified an interstitial duplication dup(2)(q34q33) using multiple, complementary molecular cytogenetic techniques. Comparative genomic hybridisation (CGH) and array-CGH were used to determine the size and the location of the duplicated region, the orientation of the duplicated region was identified with fluorescence in situ hybridisation (FISH). Both parents demonstrated a normal karyotype and normal CGH and array-CGH-profiles. However, FISH on peripheral blood cells from the mother showed the inv dup(2) in 9% of metaphases and 19% of interphase nuclei. To our knowledge this is the first report of a mosaic carrier of duplication in the long arm of chromosome 2. The finding of chromosomal mosaicism of at least 19% in the mother increases the recurrence risk. The exact characterisation of the inv dup(2) with FISH probes enabled us to offer a reliable prenatal FISH test. Comparison of the clinical features of the two children with those of previously described cases supports the hypothesis that the characteristic facial phenotype is linked to the distal part of the 2q33-q37 region. This report illustrates that in case of two sibs with an identical structural chromosomal abnormality the possibility of parental chromosomal mosaicism must be thoroughly investigated. 相似文献
129.
Noelia Sanmamed Pino Alcantara Elena Cerezo Miren Gaztañaga Noemi Cabello Sara Gómez Ana Bustos Anxela Doval Juan Corona Gabriel Rodriguez Mercedes Duffort Francisco Ortuño Javier de Castro Manuel Enrique Fuentes Alvaro Sanz Amanda López Manuel Vazquez 《International journal of radiation oncology, biology, physics》2021,109(4):880-885
130.
Oterino de la Fuente D Baños Pino JF Fernández Blanco V Rodríguez Alvarez A Peiró S 《Gaceta sanitaria / S.E.S.P.A.S》2007,21(4):316-320
OBJECTIVE: To describe primary care and hospital emergency utilization rates in Asturias health districts from 1994 to 2001 and to analyse their variability. METHODS: Hospital and primary care rates from 1994 to 2001 in the 8 Asturias health districts were estimated. Their variability was analysed using indirect standardisation and small area variation statistics. RESULTS: Almost 6.5 million of emergencies (hospitals: 43.8%) were attended in Asturias from 1994 to 2001. The average annual growth was 6.2% (primary care: 7.8%; hospitals: 5.1%) with differences among districts. Primary care variability was higher (variation coefficient: 0.38 and 0.27 in 1994 and 2001) than hospital variability (variation coefficient: 0.14 and 0.11) and it decreased in the period. CONCLUSIONS: Emergency Health Services utilization growth between 1994 and 2001, with strong variability among health districts. 相似文献