全文获取类型
收费全文 | 2175篇 |
免费 | 100篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 44篇 |
妇产科学 | 127篇 |
基础医学 | 236篇 |
口腔科学 | 16篇 |
临床医学 | 142篇 |
内科学 | 559篇 |
皮肤病学 | 46篇 |
神经病学 | 230篇 |
特种医学 | 78篇 |
外科学 | 299篇 |
综合类 | 8篇 |
预防医学 | 88篇 |
眼科学 | 42篇 |
药学 | 122篇 |
中国医学 | 3篇 |
肿瘤学 | 247篇 |
出版年
2023年 | 18篇 |
2022年 | 51篇 |
2021年 | 56篇 |
2020年 | 29篇 |
2019年 | 43篇 |
2018年 | 56篇 |
2017年 | 46篇 |
2016年 | 58篇 |
2015年 | 55篇 |
2014年 | 103篇 |
2013年 | 107篇 |
2012年 | 175篇 |
2011年 | 146篇 |
2010年 | 89篇 |
2009年 | 78篇 |
2008年 | 153篇 |
2007年 | 141篇 |
2006年 | 161篇 |
2005年 | 135篇 |
2004年 | 147篇 |
2003年 | 113篇 |
2002年 | 84篇 |
2001年 | 18篇 |
2000年 | 11篇 |
1999年 | 21篇 |
1998年 | 40篇 |
1997年 | 22篇 |
1996年 | 20篇 |
1995年 | 14篇 |
1994年 | 22篇 |
1993年 | 6篇 |
1992年 | 6篇 |
1991年 | 12篇 |
1990年 | 4篇 |
1989年 | 4篇 |
1988年 | 9篇 |
1987年 | 2篇 |
1985年 | 6篇 |
1984年 | 6篇 |
1983年 | 5篇 |
1982年 | 4篇 |
1981年 | 2篇 |
1980年 | 3篇 |
1977年 | 2篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1973年 | 2篇 |
1972年 | 1篇 |
1971年 | 1篇 |
1969年 | 1篇 |
排序方式: 共有2293条查询结果,搜索用时 31 毫秒
21.
Zannolli R Mostardini R Pucci L Sorrentino L Biagioli M Perotti R Guarna M Hadjistilianou T Zerega G Pierluigi M Franco B D'Ambrosio A Morgese G 《American journal of medical genetics》2001,102(1):29-35
We report on a 2-year-old girl with a de novo mutation [45,XX,der(5),t(5;14) (pter;q11.2)] with corpus callosum agenesis, multiple cysts (cerebral and cardiac), subtle eye abnormalities, and at least two different skin defects, strongly indicating neuroectodermal involvement, as a neuromuscular choristoma (hamartoma) and an eccrine hamartoma. Fluorescent in situ hybridization with different single-locus probes showed that chromosome 5 has a very small deletion, confined to a region composed of repetitive sequences. By contrast, the long (q) arm of chromosome 14 seems to be much more involved in the rearrangement, with partial monosomy spanning from the centromere to the D14S72 and D14S261 loci. The extent of the deleted region of chromosome 14 is approximately 16 cM. To our knowledge, this is the smallest reported deletion involving the chromosome 14q11.2 region to be associated with a developmental disorder resulting in variable eye, skin, and brain anomalies. We suggest that a new syndrome, mimicking in some ways the MLS phenotype, is caused by a deletion in the chromosome 14q11.2 region. 相似文献
22.
Ferdinando Nicoletti Roberto di Marcou Wilma Barcelliniu Gaetano Magro Hans U. Schorlemmeru Roland Kurrleu Michele Lunettau Sebastiano Grasso Paola Zacconeu Pierluigi Meronif 《European journal of immunology》1994,24(8):1843-1847
We have evaluated the effects of a treatment with soluble interleukin-1 receptor (sIL-1R) in the accelerated model of autoimmune diabetes induced by cyclophosphamide (CY) in the non-obese diabetic (NOD) mouse. Prior to the CY challenge (350 mg/kg body weight), female euglycemic NOD mice were randomly divided into three groups (A–C). Groups B and C were treated daily from 1 day before to 13 days after the CY challenge with sIL-1R at doses of 0.2 and 2 mg/kg body weight. Group A was treated with PBS. By 2 weeks after CY administration, an acute form of autoimmune diabetes with glycosuria, hyperglycemia and severe insulitis occurred in the majority (13/20, 65%) of the control mice (group A). In contrast, repeated injections with sIL-1R protected NOD mice from insulin-dependent diabetes mellitus (IDDM) development in a dose-dependent fashion; the incidence of IDDM was 53.3% (8/15) in the mice treated with 0.2 mg/kg and only 6.7% (1/15) in those treated with 2 mg/kg. However, none of the doses of the sIL-1R reduced the extent of insulitis in NOD mice. Importantly, the anti-diabetogenic property of sIL-1R may not involve major T cell function impairment; accordingly, in parallel experiments, splenic lymphoid cells from NOD mice not challenged with CY, but treated with 2 mg/kg sIL-1R for 5 consecutive days showed a normal distribution of mononuclear cell subsets and maintained their capacity to secrete interferon-γ and IL-2 and to proliferate in response to polyclonal mitogenic stimulation with concanavalin A. 相似文献
23.
Clinical Features of Fatal Familial Insomnia: Phenotypic Variability in Relation to a Polymorphism at Codon 129 of the Prion Protein Gene 总被引:2,自引:0,他引:2
Pasquale Montagna Pietro Cortelli Patrizia Avoni Paolo Tinuper Giuseppe Plazzi Roberto Gallassi Francesco Portaluppi Jean Julien Claude Vital Marie Bernadette Delisle Pierluigi Gambetti Elio Lugaresi . 《Brain pathology (Zurich, Switzerland)》1998,8(3):515-520
Fatal Familial Insomnia is a hereditary prion disease characterized by a mutation at codon 178 of the prion protein gene cosegregating with the methionine polymorphism at codon 129 of the mutated allele. It is characterized by disturbances of the wake-sleep cycle, dysautonomia and somatomotor manifestations (myoclonus, ataxia, dysarthria, spasticity). PET studies disclose severe thalamic and additionally cortical hypometabolism. Neuropathology shows marked neuronal loss and gliosis in the thalamus, especially the medio-dorsal and anterior-ventral nuclei, olivary hypertrophy and some spongiosis of the cerebral cortex. Detailed analysis of 14 cases from 5 unrelated families showed that patients ran either a short (9.1+ 1.1 months) or a prolonged (30.8 + 21.3 months) clinical course according to whether they were homozygote met/met or heterozygote met/val at codon 129. Moreover, homozygotes had more prominent oneiric episodes, insomnia and dysautonomia at onset, whereas heterozygotes showed ataxia and dysarthria at onset, earlier sphincter loss and epileptic Grand Mai seizures; they also displayed more extensive cortical involvement on PET and at postmortem examination. Our data suggest that the phenotype expression of Fatal Familial Insomnia is related, at least partly, to the polymorphism at codon 129 of the prion protein-gene. 相似文献
24.
Pierluigi Zoccolotti 《Behavior genetics》1978,8(4):377-379
Evidence for an inherited component in the determination of the preferred eye in sighting dominance is presented that replicates the earlier findings by Merrell (1957). Significantly more left-sighting-preferent individuals were found in the progeny of R×L and L×L matings than in the R×R matings.The preparation of this study was supported by National Institute of Mental Health Grant MH-21989. 相似文献
25.
Riccardo Asero Alberto Tedeschi Maurizio Lorini Maria Gerosa Pierluigi Meroni Piersandro Riboldi 《Annals of allergy, asthma & immunology》2003,91(1):79-81
BACKGROUND: The nature of histamine-releasing factors involved in the pathogenesis of chronic idiopathic urticaria (CIU) is still controversial, since functional IgG autoantibodies specific for the high-affinity IgE receptor, Fc(epsilon)RI, can be detected in only 20% of patients showing a strong skin reactivity on the autologous serum skin test. The absence of systemic eosinophilia in CIU patients, along with the increase in mast cells in skin biopsy specimens, suggests a possible role for stem cell factor (SCF), the only cytokine/growth factor known to induce mediator release from human mast cells. OBJECTIVE: To investigate the possible role of SCF as a histamine-releasing factor in patients with CIU. METHODS: The SCF levels were measured in serum samples from 65 patients with CIU who scored strongly positive on the autologous serum skin test; of these patients, 32 had negative results and 33 had positive results on in vitro histamine release assay by a quantitative commercial sandwich immunoassay technique. Serum samples from 40 healthy subjects were used as controls. RESULTS: Serum SCF levels in all 65 CIU patients did not differ from those found in healthy controls. No difference in SCF levels was found between patients with positive and negative results on histamine release assay. CONCLUSIONS: An increase in serum SCF levels does not play a pathogenic role in CIU. 相似文献
26.
27.
Ann W. Hsing Joseph K. McLaughlin Pierluigi Cocco Harvey T. Co Chien Joseph F. Fraumeni Jr. 《Cancer causes & control : CCC》1998,9(3):269-275
Objectives: The etiology of male breast cancer is obscure, although an excess risk has been associated with Klinefelter syndrome, testicular disorders, benign breast disease including gynecomastia, use of exogenous estrogens, radiation, and a family history of male or female breast cancer. We conducted a case-control study to investigate risk factors further for breast cancer in men.Methods: Based on data from the 1986 National (United States) Mortality Followback Survey (NMFS) of almost 20,000 deceased adults (age 25 years or over), we compared information obtained from next-of-kin interviews of 178 men who died of breast cancer with that of 512 male controls who died of other causes. Information was obtained on selected demographic and other factors, including diet, exercise, occupation, height and weight, and use of tobacco and alcohol.Results: Increased risks were found for men who were described by their next-of-kin as very overweight (odds ratio [OR] = 2.3, 95 percent confidence interval [CI] = 1.1-5.0). The risks associated with the three upper quartiles of body mass index (BMI) (wt/ht2) were 1.3, 1.6, and 2.3, respectively, with a significant dose-response relationship (P < 0.01). An excess risk was also associated with limited exercise (OR = 1.3, CI = 0.8-2.0). Consumption of red meat was associated with an increased risk, and consumption of fruits and vegetables with a decreased risk, although the trends were not significant. No association was found for tobacco or alcohol use, but an excess risk was associated with higher levels of socioeconomic status (SES) (OR = 1.8, CI = 1.1-3.0).Conclusions: Our study suggests that obesity increases the risk of male breast cancer, possibly through hormonal mechanisms, while dietary factors, physical activity, and SES indicators also deserve further investigation. Cancer Causes andd Control 1998, 269-275 相似文献
28.
Enrico Zecca Daniele de Luca Simonetta Costa Marco Marras Pierluigi de Turris Costantino Romagnoli 《The journal of maternal-fetal & neonatal medicine》2006,19(9):569-574
OBJECTIVE: To investigate the effect of different delivery room strategies on survival, short term morbidity, and outcomes in extremely premature infants. METHODS: This retrospective cohort study included all preterm infants with a gestational age between 24 and 28 weeks who were born in 1992-1997 (period A; n = 161) and in 1998-2003 (period B; n = 163). In period A, elective intubation was performed. In period B, if spontaneous breathing was present, nasal continuous positive airway pressure (nCPAP) was applied. RESULTS: Survival rate and the number of never-intubated infants significantly increased in period B. No differences were found concerning short-term morbidity. Among major outcomes, the need for retinopathy of prematurity (ROP) surgery and the length of stay were significantly lower in period B. Subgroup analysis showed no significant differences from period A to period B in infants with gestational age 24-26 weeks. In the 27-28 weeks subgroup, the never-intubated infants rate increased from 2.8% to 21.3% and survival rate increased from 63% to 79%. A reduced need for ROP surgery and a shorter hospital stay were also observed. CONCLUSIONS: Changes in delivery room strategy tending to reduce mechanical ventilation in extremely premature infants are likely to benefit essentially infants of 27-28 weeks of gestation. Extension of such benefits to premature infants at the limit of viability requires further research. 相似文献
29.
30.
Angiography vs transesophageal echocardiography‐guided patent foramen ovale closure: A propensity score matched analysis of a two‐center registry 下载免费PDF全文