全文获取类型
收费全文 | 24622篇 |
免费 | 1524篇 |
国内免费 | 176篇 |
专业分类
耳鼻咽喉 | 235篇 |
儿科学 | 530篇 |
妇产科学 | 467篇 |
基础医学 | 3662篇 |
口腔科学 | 275篇 |
临床医学 | 2321篇 |
内科学 | 6154篇 |
皮肤病学 | 365篇 |
神经病学 | 2119篇 |
特种医学 | 1071篇 |
外国民族医学 | 8篇 |
外科学 | 4212篇 |
综合类 | 69篇 |
一般理论 | 4篇 |
预防医学 | 1343篇 |
眼科学 | 278篇 |
药学 | 1352篇 |
中国医学 | 41篇 |
肿瘤学 | 1816篇 |
出版年
2023年 | 135篇 |
2022年 | 220篇 |
2021年 | 606篇 |
2020年 | 364篇 |
2019年 | 585篇 |
2018年 | 690篇 |
2017年 | 464篇 |
2016年 | 558篇 |
2015年 | 711篇 |
2014年 | 935篇 |
2013年 | 1204篇 |
2012年 | 1912篇 |
2011年 | 1891篇 |
2010年 | 1095篇 |
2009年 | 1103篇 |
2008年 | 1685篇 |
2007年 | 1699篇 |
2006年 | 1662篇 |
2005年 | 1707篇 |
2004年 | 1576篇 |
2003年 | 1492篇 |
2002年 | 1404篇 |
2001年 | 208篇 |
2000年 | 153篇 |
1999年 | 226篇 |
1998年 | 266篇 |
1997年 | 232篇 |
1996年 | 193篇 |
1995年 | 163篇 |
1994年 | 117篇 |
1993年 | 142篇 |
1992年 | 107篇 |
1991年 | 81篇 |
1990年 | 81篇 |
1989年 | 58篇 |
1988年 | 58篇 |
1987年 | 45篇 |
1986年 | 51篇 |
1985年 | 47篇 |
1984年 | 40篇 |
1983年 | 49篇 |
1982年 | 41篇 |
1981年 | 48篇 |
1980年 | 37篇 |
1979年 | 21篇 |
1978年 | 16篇 |
1977年 | 15篇 |
1976年 | 14篇 |
1975年 | 20篇 |
1972年 | 12篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
12.
13.
14.
Etienne Challet Sylviane Gourmelen Paul Pevet Philippe Oberling Laure Pain 《Neuropsychopharmacology》2007,32(3):728-735
Several common postdischarge symptoms, such as sleep disorders, headache, drowsiness or general malaise, evoke disturbances of circadian rhythms due to jet lag (ie crossing time zones) or shift work rotation. Considering that general anesthesia is associated with numerous effects on the central nervous system, we hypothesized that it may also act on the circadian timing system. We first determined the effects of the circadian timing on general anesthesia. We observed that identical doses of propofol showed marked circadian fluctuations in duration of effects, with a peak at the middle of the resting period (ie 7 h after lights on). Then, we examined the effects of general anesthesia on circadian timing, by analysing stable free-running circadian rhythms (ie in constant environmental conditions), an experimental approach used widely in circadian biology. Free-running rats were housed in constant darkness and temperature to assess possible phase-shifting effects of propofol anesthesia according to the time of the day. When administered around (+/-2 h) the daily rest/activity transition point, a 30-min propofol anesthesia induced a 1-h phase advance in the free-running rest-activity rhythm, while anesthesia had no significant resetting effect at other times of the day. Anesthesia-induced hypothermia was not correlated with the phase-shifting effects of propofol anesthesia. From our results, anesthesia itself can reset circadian timing, and acts as a synchronizing cue for the circadian clock. 相似文献
15.
In the last few years, survival of patients infected with human immunodeficiency virus (HIV) has been improved because of a decreased incidence of some opportunistic complications attributable to prophylactic treatments and antiretroviral drugs. The impact of these agents should also be reflected in the quality of life (QoL) of patients. We have reviewed this topic with an emphasis on different types of measurements such as Q-TWIST, MOS and the Spitzer score which seem to be most appropriate for this patient population. We do not think that a special type of assessment should be designed for HIV-infected persons. It would be less time-consuming to improve already existing validated scores focusing on HIV infection. QoL in intravenous drug users with HIV should be evaluated more often. 相似文献
16.
Jean-Luc Garrigue Philippe Catroux Jacques Leclaire 《Clinical reviews in allergy & immunology》1995,13(3):189-200
Conclusion The search for a link between cellular and molecular events involved in delayed-type CHS reactions and the early molecular
activation of xenobiotics is a new field of research. It should largely contribute to the debate on the best way forward for
predictive toxicology in general. 相似文献
17.
To study the effect of different schedules of allergen administration on the early (EAR) and late allergic reaction (LAR), 15 asthmatic patients with dual response after allergen challenge were submitted to two consecutive bronchoprovocation tests (BPT). BPT1 was carried out with semilogarithmic increase of allergen doses until a FEV1 drop of 20% was recorded. BPT2 was performed 2 weeks later using the highest allergen dose that had elicited the dual reaction in BPT1. Both EAR and LAR were very similar for a given patient. As the allergen dose used in BPT2 is smaller than the cumulative allergen dose administered in BPT1, this protocol takes into account a possible influence on BPT2 of bronchial hyperreactivity induced by BPT1 performed 2 weeks before. 相似文献
18.
Michel Rostin Philippe Barthe Georges Houin Michel Alvinerie François Bouissou 《Pediatric nephrology (Berlin, Germany)》1990,4(5):470-473
The aim of this study was to establish whether the criteria for the clinical effectiveness of steroids are correlated with the pharmacokinetics of prednisolone in children treated with prednisone during an attack of idiopathic nephrotic syndrome (INS). Thirteen patients with nephrosis were included. Prednisolone, prednisone and cortisol levels were measured using a specific high-performance liquid chromatography assay after an oral dose of 1 mg/kg body weight of prednisone taken at the onset of the disease. All the pharmacokinetic parameters, including the conversion of prednisone to prednisolone were similar to the data already published in children with INS. No correlation was found between the values of pharmacokinetic parameters and criteria of clinical effectiveness. Hypo-albuminaemia was significantly correlated with the area under the plasma-concentration curve but not with the elimination half-life of prednisolone. Moreover, the prednisolone elimination half-life correlated with the urinary exretion of 17-hydroxycorticosteroids achieved in the first 6h. The present study suggests that routine measurements of prednisolone kinetics do not help when assessing the treatment of children with INS. 相似文献
19.
Philippe Brun Heykel Kchouk Brigitte Mouchet Véronique Baudouin Alain Raynaud Chantal Loirat Annabelle Azancot-Benisty 《Pediatric nephrology (Berlin, Germany)》1997,11(1):27-30
To evaluate the reliability of Doppler ultrasonography (US) in identifying children with renal artery stenosis (RAS) among
those with hypertension, we compared Doppler US results in 22 hypertensive children (mean age 8.9±4.3 years), with (13 cases)
and without RAS at angiography, and in 33 normotensive children (mean age 8.8±4.7 years). We observed 2 false-negatives and
2 false-positives with Doppler US. Of the 2 false-negative diagnoses, 1 had RAS on an accessory renal artery located behind
a normal upper polar artery and the other was observed in a patient with bilateral multiple stenosis of the very distal segments
of renal arteries. The 2 false-positive diagnoses were due to sinuous left renal artery and to technical reasons, respectively.
In another patient, Doppler US showed a tight RAS, while arteriography was normal. RAS was subsequently confirmed by a second
arteriography. Peak systolic velocity values of Doppler US were significantly higher in patients with proven angiographic
RAS (3.44±0.66 m/s) than in hypertensive patients with normal renal arteries at angiography (0.99±0.35 m/s, P <0.0001) and normotensive healthy children (1.04±0.23 m/s, P <0.0001). With the use of multiple views, and the experience acquired with practice, false-negatives or false-positives due
to the geometry of the renal artery can be avoided. Nevertheless, very distal stenosis can be missed by Doppler US.
Received October 30, 1995; received in revised form April 16, 1996; accepted May 14, 1996 相似文献
20.