全文获取类型
收费全文 | 10371篇 |
免费 | 821篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 54篇 |
儿科学 | 242篇 |
妇产科学 | 139篇 |
基础医学 | 1376篇 |
口腔科学 | 177篇 |
临床医学 | 1180篇 |
内科学 | 1684篇 |
皮肤病学 | 139篇 |
神经病学 | 1518篇 |
特种医学 | 449篇 |
外科学 | 1163篇 |
综合类 | 156篇 |
一般理论 | 11篇 |
预防医学 | 1190篇 |
眼科学 | 275篇 |
药学 | 787篇 |
中国医学 | 21篇 |
肿瘤学 | 643篇 |
出版年
2022年 | 65篇 |
2021年 | 145篇 |
2020年 | 86篇 |
2019年 | 132篇 |
2018年 | 162篇 |
2017年 | 128篇 |
2016年 | 172篇 |
2015年 | 200篇 |
2014年 | 232篇 |
2013年 | 325篇 |
2012年 | 483篇 |
2011年 | 503篇 |
2010年 | 305篇 |
2009年 | 256篇 |
2008年 | 476篇 |
2007年 | 498篇 |
2006年 | 486篇 |
2005年 | 499篇 |
2004年 | 488篇 |
2003年 | 464篇 |
2002年 | 465篇 |
2001年 | 248篇 |
2000年 | 349篇 |
1999年 | 300篇 |
1998年 | 148篇 |
1997年 | 115篇 |
1996年 | 143篇 |
1995年 | 118篇 |
1994年 | 97篇 |
1993年 | 101篇 |
1992年 | 205篇 |
1991年 | 209篇 |
1990年 | 280篇 |
1989年 | 184篇 |
1988年 | 202篇 |
1987年 | 161篇 |
1986年 | 149篇 |
1985年 | 160篇 |
1984年 | 129篇 |
1983年 | 115篇 |
1982年 | 95篇 |
1981年 | 105篇 |
1980年 | 67篇 |
1979年 | 90篇 |
1978年 | 80篇 |
1977年 | 56篇 |
1975年 | 57篇 |
1974年 | 54篇 |
1972年 | 50篇 |
1968年 | 55篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
22.
23.
M. L. Margallo-Lana P. B. Moore D. W. K. Kay R. H. Perry B. E. Reid T. P. Berney & S. P. Tyrer 《Journal of intellectual disability research : JIDR》2007,51(6):463-477
Background The clinical and neuropathological features associated with dementia in Down’s syndrome (DS) are not well established. Aims To examine clinico‐pathological correlations and the incidence of cognitive decline in a cohort of adults with DS. Method A total of 92 hospitalized persons with DS were followed up from 1985 to December 2000. At outset, 87 participants were dementia‐free, with a median age of 38 years. Assessments included the Prudhoe Cognitive Function Test (PCFT) and the Adaptive Behavior Scale (ABS), to measure cognitive and behavioural deterioration. Dementia was diagnosed from case records and caregivers’ reports. Results Eighteen (21%) patients developed dementia during follow‐up, with a median age of onset 55.5 years (range 45–74). The PCFT demonstrated cognitive decline among those with a less severe intellectual disability (mild and moderate) but not among the profoundly disabled people (severe and profound). Clinical dementia was associated with neuropathological features of Alzheimer’s disease, and correlated with neocortical neurofibrillary tangle densities. At the age of 60 years and above, a little more than 50% of patients still alive had clinical evidence of dementia. Conclusions Clinical dementia associated with measurable cognitive and functional decline is frequent in people with DS after middle age, and can be readily diagnosed among less severely intellectually disabled persons using measures of cognitive function such as the PCFT and behavioural scales such as the ABS. In the more profoundly disabled people, the diagnosis of dementia is facilitated by the use of behavioural and neurological criteria. In this study, the largest prospective DS series including neuropathology on deceased patients, the density of neurofibrillary tangles related more closely to the dementia of DS than senile plaques. In people with DS surviving to middle and old age, the development of dementia of Alzheimer type is frequent but not inevitable, and some people with DS reach old age without clinical features of dementia. 相似文献
24.
Chemotherapeutic agents and hepatotoxicity. 总被引:4,自引:0,他引:4
M C Perry 《Seminars in oncology》1992,19(5):551-565
25.
Exposure of animals to aversive events produces stress-induced analgesia. A common method of producing stress in animals is the cold-water swim (CWS). The present series of experiments examines the effect of CWS on tonic pain, as measured by the formalin test, and explores possible mechanisms of action. Experiment 1 demonstrates that a 3.5-min swim in 2°C water produces a delayed nociceptive response (DNR), characterized by a prolonged period of no formalin responding which then begins and continues during the time when control animals, which have not received the CWS, are finished responding. The delayed response begins at 50–60 min postformalin injection, peaks at 80 min, and is still present at 120 min. Experiment 2 indicates that paw temperature effects are not responsible for the DNR, although core body temperature effects are a possible mechanism. However, systematic delays in the formalin injection following the CWS (Experiment 3) drastically altered the DNR even though core body temperature remained unchanged, suggesting that a decrease of core body temperature is insufficient to account for the DNR. Experiment 4 demonstrates that the NMDA antagonist MK-801 administered prior to the CWS dramatically reduces the DNR. The present experiment is the first study that reports a delay as long as 60 min in pain responding. It is concluded that the delayed response to formalin injection is the result of complex interactions involving peripheral mechanisms and central neuronal plasticity in which activity initiated by a noxious input persists after the cessation of the input as a consequence of a stressful event such as the cold-water swim. 相似文献
26.
P. H. Whincup M. A. Mendall I. J. Perry D. P. Strachan M. Walker 《Heart (British Cardiac Society)》1996,75(6):568-572
OBJECTIVE: To determine whether Helicobacter pylori, a chronic bacterial infection often acquired in childhood, is associated with increased risk of coronary heart disease and stroke later in life. DESIGN: Nested case-control study. SETTING: Prospective study of cardiovascular disease in men aged 40-59 years at entry (1978-1980) in 24 British towns. SUBJECTS: 135 cases of myocardial infarction and 137 cases of stroke occurring before December 1991; 136 controls were identified, frequency matched to cases by town and age group. METHODS: Serum samples stored at entry were analysed by an enzyme linked immunosorbent assay for the presence of H pylori specific IgG antibodies. RESULTS: 95 of the myocardial infarction cases (70%) and 93 (68%) of the stroke cases were seropositive for H pylori compared with 78 (57%) of the controls (odds ratio for myocardial infarction 1.77, 95% confidence interval (CI) 1.06 to 2.95, P = 0.03; odds ratio for stroke 1.57, 95% CI 0.95 to 2.60, P = 0.07). Helicobacter pylori infection was associated with manual social class, residence in Northern England or Scotland, cigarette smoking, higher systolic pressure and blood glucose, and a lower height-standardised forced expiratory volume in one second. Adjustment for these factors attenuated the relation between H pylori and myocardial infarction (odds ratio = 1.31, 95% CI 0.70 to 2.43, P = 0.40) and effectively abolished the relation with stroke (odds ratio = 0.96, 0.46 to 2.02, P = 0.92). The relation between helicobacter infection and fatal myocardial infarction was slightly stronger (odds ratio 2.41, 95% CI 1.13 to 5.12) but was also markedly attenuated after adjustment (1.56, 95% CI 0.68 to 3.61). CONCLUSION: In this prospective study the association between Helicobacter pylori infection and increased risk of myocardial infarction and stroke was substantially confounded by the relation between this infection, adult social class, and major cardiovascular risk factors. 相似文献
27.
Memory following cholinergic (NBM) and noradrenergic (DNAB) lesions made singly or in combination: potentiation of disruption by scopolamine 总被引:1,自引:0,他引:1
A Sahgal A B Keith S Lloyd J M Kerwin E K Perry J A Edwardson 《Pharmacology, biochemistry, and behavior》1990,37(4):597-605
Groups of rats were trained on either delayed matching or nonmatching to position tasks, then divided into four subgroups and given the following bilateral lesions: (a) SHAM [vehicle injection into the nucleus basalis magnocellularis (NBM) and dorsal noradrenergic bundle (DNAB)], (b) DNAB (6-hydroxydopamine lesion of the DNAB, vehicle into the NBM), (c) NBM (quisqualic acid lesion of the NBM, vehicle into the DNAB) and (d) DUAL (neurotoxin lesions of both DNAB and NBM). Following postoperative recovery, the DUAL lesion subjects were slightly impaired, but by the seventh day of testing all groups were performing at similar levels. This strongly suggests that quisqualate lesions of the NBM are not sufficient to produce severe and lasting mnemonic disorders resembling those seen in Alzheimer's disease (AD). These data also indicate that the noradrenergic system may not be of critical importance with respect to cognition. It was reasoned that an additional anticholinergic treatment might exacerbate an underlying deficiency. All groups were injected, peripherally, with the cholinergic antagonist scopolamine (0-0.5 mg/kg). This drug dose-dependently disrupted performance in all groups. Moreover, the highest dose had a marked effect in the DUAL group, impairing performance even when no mnemonic burden was present (at zero delay). The results suggest that cholinergic NBM and noradrenergic DNAB lesions produce only transient mnemonic deficiencies. A combination of the two can be disruptive, but longer term task (or reference) memory is the primary process affected, and only under certain conditions. The implication of these findings to research concerning animal models relating to Alzheimer's disease is discussed. 相似文献
28.
Endovascular stent implantation in patients with stenotic aortoarteriopathies: early and medium-term results. 总被引:1,自引:0,他引:1
Ernest S Siwik Stanton B Perry James E Lock 《Catheterization and cardiovascular interventions》2003,59(3):380-386
Data regarding stent implantation for stenotic aortoarteriopathy (SAA) are incomplete. We report on nine patients with this rare syndrome who underwent arterial stent implantation. Indications, results, and complications for patients with SAA were reviewed. Nine patients underwent 11 procedures. Twenty-two stents were implanted in the aorta or brachiocephalic vessels. Five patients had diffuse stenoses, three patients had middle aortic syndrome, and one patient had thoracic and abdominal coarctation. Associated diagnoses included Williams syndrome (2), neurofibromatosis (2), Takayasu's (1), and congenital rubella (1). Median gradient was 60 mm Hg (20-140 mm Hg). Poststent gradient was 15 mm Hg (0-60 mm Hg; P < 0.001). Additional stents were implanted in two patients and five underwent stent redilation. Two patients (22%) were found to have aneurysm formation. Stent implantation effectively provides gradient relief in SAA. Gradient reduction persists or is amenable to redilation. Importantly, however, uncomplicated stent implantation does not preclude aneurysm formation and may be more common than in traditional patient groups. 相似文献
29.
Cognitive functioning and psychiatric symptomatology in patients with chronic hepatitis C. 总被引:2,自引:0,他引:2
Robin C Hilsabeck Tarek I Hassanein Meghan D Carlson Elizabeth A Ziegler William Perry 《Journal of the International Neuropsychological Society》2003,9(6):847-854
Hepatitis C virus (HCV) infection is a major public-health-care problem, with over 170 million infected worldwide. Patients with chronic HCV infection often complain of various cognitive problems as well as symptoms of depression, anxiety, and fatigue. Relatively little is known, however, about the specific cognitive deficits that are common among HCV patients, and the influence of psychiatric symptomatology on cognitive functioning. In the current study of 21 chronically infected HCV patients, we assessed subjective cognitive dysfunction, depression, anxiety, and fatigue and compared these symptom areas to cognitive tests assessing visuoconstruction, learning, memory, visual attention, psychomotor speed, and mental flexibility. Results revealed that cognitive impairment ranged from 9% of patients on a visuoconstruction task to 38% of patients on a measure of complex attention, visual scanning and tracking, and psychomotor speed, and greater HCV disease severity as indicated by liver fibrosis was associated with greater cognitive dysfunction. Objective cognitive impairment was not related to subjective cognitive complaints or psychiatric symptomatology. These findings suggest that a significant portion of patients with chronic HCV experience cognitive difficulties that may interfere with activities of daily living and quality of life. Future research using cognitive measures with HCV-infected patients may assist researchers in identifying if there is a direct effect of HCV infection on the brain and which patients may be more likely to progress to cirrhosis and hepatic encephalopathy. 相似文献
30.