全文获取类型
收费全文 | 1407615篇 |
免费 | 115706篇 |
国内免费 | 3330篇 |
专业分类
耳鼻咽喉 | 18355篇 |
儿科学 | 46570篇 |
妇产科学 | 41073篇 |
基础医学 | 200703篇 |
口腔科学 | 37682篇 |
临床医学 | 125880篇 |
内科学 | 284067篇 |
皮肤病学 | 33349篇 |
神经病学 | 116794篇 |
特种医学 | 53822篇 |
外国民族医学 | 464篇 |
外科学 | 210470篇 |
综合类 | 32745篇 |
现状与发展 | 3篇 |
一般理论 | 487篇 |
预防医学 | 109857篇 |
眼科学 | 31455篇 |
药学 | 98474篇 |
1篇 | |
中国医学 | 3347篇 |
肿瘤学 | 81053篇 |
出版年
2021年 | 10855篇 |
2019年 | 11671篇 |
2018年 | 16575篇 |
2017年 | 12667篇 |
2016年 | 14260篇 |
2015年 | 16007篇 |
2014年 | 22560篇 |
2013年 | 33389篇 |
2012年 | 45383篇 |
2011年 | 47914篇 |
2010年 | 28157篇 |
2009年 | 27052篇 |
2008年 | 44313篇 |
2007年 | 46815篇 |
2006年 | 47386篇 |
2005年 | 45849篇 |
2004年 | 43742篇 |
2003年 | 41691篇 |
2002年 | 40192篇 |
2001年 | 73006篇 |
2000年 | 74531篇 |
1999年 | 61556篇 |
1998年 | 16990篇 |
1997年 | 15430篇 |
1996年 | 15581篇 |
1995年 | 14789篇 |
1994年 | 13395篇 |
1993年 | 12581篇 |
1992年 | 45837篇 |
1991年 | 43478篇 |
1990年 | 41486篇 |
1989年 | 39551篇 |
1988年 | 36179篇 |
1987年 | 35351篇 |
1986年 | 32860篇 |
1985年 | 31276篇 |
1984年 | 23823篇 |
1983年 | 20023篇 |
1982年 | 12207篇 |
1981年 | 10779篇 |
1979年 | 20700篇 |
1978年 | 14576篇 |
1977年 | 12084篇 |
1976年 | 11365篇 |
1975年 | 11620篇 |
1974年 | 13988篇 |
1973年 | 13534篇 |
1972年 | 12634篇 |
1971年 | 11469篇 |
1970年 | 10910篇 |
排序方式: 共有10000条查询结果,搜索用时 250 毫秒
121.
J. Savige L. Amos Frank Ierino H. G. Mack R. C. Andrew Symons P. Hughes 《Ophthalmic genetics》2016,37(4):369-376
Background: Dense deposit disease and atypical hemolytic uremic syndrome are often caused by Complement Factor H (CFH) mutations. This study describes the retinal abnormalities in dense deposit disease and, for the first time, atypical haemolytic uremic syndrome. It also reviews our understanding of drusen pathogenesis and their relevance for glomerular disease. Methods: Six individuals with dense deposit disease and one with atypical haemolytic uremic syndrome were studied from 2 to 40 years after presentation. Five had renal transplants. All four who had genetic testing had CFH mutations. Individuals underwent ophthalmological review and retinal photography, and in some cases, optical coherence tomography, and further tests of retinal function. Results: All subjects with dense deposit disease had impaired night vision and retinal drusen or whitish-yellow deposits. Retinal atrophy, pigmentation, and hemorrhage were common. In late disease, peripheral vision was restricted, central vision was distorted, and there were scotoma from sub-retinal choroidal neovascular membranes and atypical serous retinopathy. Drusen were present but less prominent in the young person with atypical uremic syndrome due to a heterozygous CFH mutation. Conclusions: Drusen are common in forms of C3 glomerulopathy caused by compound heterozygous or heterozygous CFH mutations. They are useful diagnostically but also impair vision. Drusen have an identical composition to glomerular deposits. They are also identical to the drusen of age-related macular degeneration, and may respond to the same treatments. Individuals with a C3 glomerulopathy should be assessed ophthalmologically at diagnosis, and monitored regularly for vision-threatening complications. 相似文献
122.
A novel BRAF mutation in association with primary amelanotic melanoma with oral metastases 下载免费PDF全文
123.
124.
125.
126.
127.
Ragnhild B. Wijma Marloes Emous Merel van den Broek Anke Laskewitz Anneke C. Muller Kobold André P. van Beek 《Surgery for obesity and related diseases》2019,15(1):73-81
Background
Early dumping is a poorly defined and incompletely understood complication after Roux-en-Y gastric (RYGB).Objective
We performed a mixed-meal tolerance test in patients after RYGB to address the prevalence of early dumping and to gain further insight into its pathophysiology.Setting
The study was conducted in a regional hospital in the northern part of the Netherlands.Methods
From a random sample of patients who underwent primary RYGB between 2008 and 2011, 46 patients completed the mixed-meal tolerance test. The dumping severity score for early dumping was assessed every 30 minutes. A sum score at 30 or 60 minutes of ≥5 and an incremental score of ≥3 points were defined as indicating a high suspicion of early dumping. Blood samples were collected at baseline, every 10 minutes during the first half hour, and at 60 minutes after the start.Results
The prevalence of a high suspicion of early dumping was 26%. No differences were seen for absolute hematocrit value, inactive glucagon-like peptide-1, and vasoactive intestinal peptide between patients with or without early dumping. Patients at high suspicion of early dumping had higher levels of active glucagon-like peptide-1 and peptide YY.Conclusion
The prevalence of complaints at high suspicion of early dumping in a random population of patients after RYGB is 26% in response to a mixed-meal tolerance test. Postprandial increases in both glucagon-like peptide-1 and peptide YY are associated with symptoms of early dumping, suggesting gut L-cell overactivity in this syndrome. 相似文献128.
129.
M. Zamparas V.C. Kapsalis G.L. Kyriakopoulos K.G. Aravossis A.E. Kanteraki A. Vantarakis I.K. Kalavrouziotis 《Sustainable Chemistry and Pharmacy》2019
At this study a multi-criteria model was developed to examine the available procedures, techniques and methods of handling infectious waste in the large healthcare unit of University Regional General Hospital of Patras, Western Greece. Particularly, this study examined the: a) current legislation and Directives issued for medical waste management at Greece and among the other EU-members, b) contribution of healthcare wastes (HCW) generation rate on social and economic parameters in selected European countries, c) available procedures, techniques, and methods upon the disposal of infectious wastes at the healthcare studied, and, d) propositions for integrated management of such hazardous wastes. Specifically, the Analytic Hierarchy Process (AHP) methodology was applied under pair wise comparison matrices in two stages: 1) the scale factors and the indicators, and 2) the criteria and their sub–criteria. The assessment of these pair wise matrices included the indicators and the sub–criteria. Subsequently, two pair wise comparison matrices, upon a) the “Fulfillment of environmental objectives” indicator and b) the “Energy consumption” sub criterion, were denoted. The AHP methodology yielded good results; however there is still space of improving the environmental performance. The normalized relative weights obtained for the criteria and sub criteria motivated specific actions that have to be handled. Particularly, the results indicated a very good value in environmental management criteria due the values obtained for the commitment towards the environmental policy standards and the waste management procedures. However, further improvements on staff awareness (such as development programs to enhance sensitivity) and more green purchasing suppliers, should be further addressed. 相似文献
130.
The term “oligometastatic prostate cancer” refers to a heterogeneous group of disease states currently defined solely on the basis of clinical features. Oligorecurrent disease, de novo oligometastases, and oligoprogressive disease likely have unique biologic underpinnings and natural histories. Evidence suggesting the existence of a subset of patients who harbor prostate cancer with limited metastatic potential currently includes disparate and overwhelmingly retrospective reports. Nevertheless, emerging prospective data have corroborated the “better-than-expected,” retrospectively observed outcomes, particularly in the setting of oligorecurrent prostate cancer. Improved functional imaging with prostate-specific membrane antigen-targeted strategies may enhance the identification of patients with oligometastatic prostate cancer in the short term. In the long term, refinement of the oligometastatic case definition likely will require biologic risk-stratification schemes. To determine optimal treatment strategies and identify patients most likely to benefit from metastasis-directed therapy, future efforts should focus on conducting high-quality, prospective trials with much-needed molecular correlative studies. 相似文献