全文获取类型
收费全文 | 9003篇 |
免费 | 1009篇 |
国内免费 | 25篇 |
专业分类
耳鼻咽喉 | 100篇 |
儿科学 | 262篇 |
妇产科学 | 122篇 |
基础医学 | 1243篇 |
口腔科学 | 182篇 |
临床医学 | 1217篇 |
内科学 | 1711篇 |
皮肤病学 | 241篇 |
神经病学 | 772篇 |
特种医学 | 342篇 |
外科学 | 1338篇 |
综合类 | 316篇 |
现状与发展 | 30篇 |
一般理论 | 7篇 |
预防医学 | 1168篇 |
眼科学 | 123篇 |
药学 | 447篇 |
1篇 | |
中国医学 | 11篇 |
肿瘤学 | 404篇 |
出版年
2023年 | 201篇 |
2021年 | 124篇 |
2020年 | 113篇 |
2019年 | 136篇 |
2018年 | 159篇 |
2017年 | 154篇 |
2016年 | 123篇 |
2015年 | 166篇 |
2014年 | 206篇 |
2013年 | 309篇 |
2012年 | 352篇 |
2011年 | 384篇 |
2010年 | 278篇 |
2009年 | 276篇 |
2008年 | 374篇 |
2007年 | 351篇 |
2006年 | 345篇 |
2005年 | 331篇 |
2004年 | 306篇 |
2003年 | 261篇 |
2002年 | 296篇 |
2001年 | 281篇 |
2000年 | 284篇 |
1999年 | 261篇 |
1998年 | 133篇 |
1997年 | 136篇 |
1996年 | 101篇 |
1995年 | 94篇 |
1994年 | 79篇 |
1993年 | 103篇 |
1992年 | 198篇 |
1991年 | 189篇 |
1990年 | 200篇 |
1989年 | 195篇 |
1988年 | 187篇 |
1987年 | 173篇 |
1986年 | 166篇 |
1985年 | 175篇 |
1984年 | 125篇 |
1983年 | 111篇 |
1982年 | 92篇 |
1981年 | 91篇 |
1980年 | 84篇 |
1979年 | 77篇 |
1978年 | 90篇 |
1977年 | 61篇 |
1976年 | 75篇 |
1975年 | 61篇 |
1974年 | 77篇 |
1971年 | 68篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
51.
Cyclosporine nephrotoxicity in lung transplant recipients. 总被引:3,自引:0,他引:3
End-stage lung disease has been treated successfully by lung transplantation (LTXP) at our institution since 1983. We report on the renal function of 30 LTXP recipients who were followed for at least 6 months (mean, 39 months; range, 6-60 months). All patients received quadruple immunosuppressive therapy including cyclosporine A, with a trough serum level (RIA) between 150 and 250 ng/ml for the first 6 months between 125 and 150 mg/ml after 6 months. The mean serum creatinine (SeCr) increased from a baseline value of 75 +/- 3.5 to 182 +/- 13.9 microM at the end of the follow-up. The greatest change in SeCr occurred within the first 6 months post LTXP. Fifteen of 30 patients who were initially normotensive required at least one antihypertensive medication post LTXP. By the end of the follow-up, 9 patients had SeCr > 200 microM. Two patients in this institution have progressed to end-stage renal disease requiring dialytic therapy. CsA nephrotoxicity has emerged as a major source of morbidity in the lung transplant population. Nephrotoxicity occurs early, and there does not appear to be any trend toward reversibility despite a lowering of the dose. Renal parenchymal injury may be progressive, despite an apparent plateau of the SeCr in some patients. 相似文献
52.
53.
Roderik Metz Gino MMJ Kerkhoffs Egbert-Jan MM Verleisdonk Geert J van der Heijden 《BMC musculoskeletal disorders》2007,8(1):108
Background
We present the design of an open randomized multi-centre study on surgical versus conservative treatment of acute Achilles tendon ruptures. The study is designed to evaluate the effectiveness of conservative treatment in reducing complications when treating acute Achilles tendon rupture. 相似文献54.
Robert L Eisner Randolph E Patterson 《Journal of nuclear medicine》2007,48(11):1912-3; author reply 1913-4
55.
Steve Ramcharitar Mark S Patterson Robert J van Geuns Martin van der Ent Georgios Sianos Gijs M J M Welten Ron T van Domburg Patrick W Serruys 《Catheterization and cardiovascular interventions》2007,70(5):662-668
OBJECTIVES: To directly compare the magnetic navigation system (MNS) guidewires with conventional guidewires in branching tortuous phantoms with operators of varying MNS and percutaneous coronary intervention experience. BACKGROUND: Vessel tortuosity, angulation, and side branches remain limiting factors in coronary interventions. The MNS addresses these limitations by precisely directing the tip of a magnetised guidewire in vivo aided by two permanent adjustable external magnets. METHODS: Crossing and fluoroscopy times of six operators were evaluated in five tortuous Perspex(R) phantom vessels in three consecutive attempts. Standard guidewire (SG) usage was unrestricted. Two 2nd generation magnetic guidewires (MG) were used. Failure was noted if the cross was unsuccessful within 5 min. RESULTS: The magnetic navigation was vastly superior to SG techniques with increasingly tortuous phantoms. It dramatically decreased both the crossing and fluoroscopy times with maximal reduction from 201.7 +/- 111 to 36.4 +/- 13 sec, P < 0.001 and 204.7 +/- 24 to 47.2 +/- 19 sec, P < 0.001, respectively. The MNS had a 98.8% procedural success rate compared to 68% with SG techniques. Moreover it considerably limited the amount of wire usage from 5.5 to 1.3. Operators with prior MG experience performed significantly better than those without, except in the simplest phantom where the difference was nonsignificant (33.8 +/- 13 sec vs. 41.7 +/- 17 sec, P = 0.2). CONCLUSION: MNS significantly reduces both the crossing and fluoroscopy times in tortuous coronary phantom models achieving excellent success rates with dramatic reductions in guidewire usage. Operators with prior MNS experience had an advantage over the inexperienced. 相似文献
56.
P Iranzo MM Alsina I Martínez-De Pablo S Segura JM Mascaró C Herrero 《Journal of the European Academy of Dermatology and Venereology》2007,21(7):902-907
BACKGROUND: The mainstay of treatment for pemphigus is systemic corticosteroids. Different adjuvants have been used to reduce side-effects of long-term corticotherapy. Gold is an anti-inflammatory drug used in autoimmune diseases, whose use has waned with the advent of new immunosuppressive agents. OBJECTIVE: To study the outcome of the use of intramuscular gold treatment of pemphigus vulgaris refractory to previous therapies. METHODS: Thirteen patients with pemphigus vulgaris who had failed to respond to several prior therapies were treated with aurothiomalate, as a steroid-sparing agent. Patients were monitored to assess disease activity and gold toxicity. RESULTS: Seven patients achieved complete remission. Four patients were able to taper prednisone doses, although pemphigus flared when prednisone was discontinued or reduced. Toxicity was observed in the other two patients. CONCLUSIONS: In 53.4% of the patients, the use of chrysotherapy resulted in the complete clearing of the disease, discontinuation of all systemic therapies and induced a long-term clinical remission. Prednisone doses were able to be reduced in the remaining 46.6%. Any side-effects were reversible with drug discontinuation. Gold therapy showed efficacy as a secondary line treatment in refractory pemphigus vulgaris. 相似文献
57.
Anthony P. Khalifah Ramsey R. Hachem Murali M. Chakinala Roger D. Yusen Aviva Aloush G. Alexander Patterson Thalachallour Mohanakumar Elbert P. Trulock Michael J. Walter 《American journal of transplantation》2005,5(8):2022-2030
Bronchiolitis obliterans syndrome (BOS) is a major cause of lung allograft dysfunction. Although previous studies have identified mild to severe rejection (grade>or=A2) as a risk factor for BOS, the role of minimal rejection (grade A1) remains unclear. To determine if A1 rejection by itself is a risk factor for BOS, we performed a retrospective cohort study on 228 adult lung transplant recipients over a 7-year period. Cohorts were defined by their most severe rejection episode (none, A1 only, and >or=A2) and analyzed for the subsequent development and progression of BOS using univariate and multivariate time-dependent Cox regression analysis. In the univariate model, the occurrence of isolated minimal rejection was a risk factor for all stages of BOS. Similarly, multivariate models that included HLA mismatch, cytomegalovirus pneumonitis, community acquired viral infection, underlying disease and type of transplant demonstrated that A1 rejection was a distinct risk factor for BOS. Furthermore, the associated risk with A1 rejection was slightly greater than the risk from >or=A2 and treatment of A1 rejection decreased the risk for subsequent BOS stage 1. We conclude that minimal rejection is associated with an increased risk for BOS development and progression that is comparable to A2 rejection. 相似文献
58.
A case of infectious mononucleosis presenting as bilateral acute dacryocystitis in a 7-year-old girl is reported. Acute dacryocystitis is uncommon in this age group, and an underlying systemic illness should be suspected particularly when it is bilateral. 相似文献
59.
D Mahalanabis H Ashraf MM Rahman GJ Fuchs 《Acta paediatrica (Oslo, Norway : 1992)》1998,87(11):1113-1115
One-hundred and six male children aged 6-23 months with a history of acute watery diarrhoea of less than 72 h duration were randomized to receive either folic acid in a dose of 5 mg at 8-h intervals or placebo for 5 d. There were 54 children in the folic acid group and 52 in the placebo group. The admission characteristics were comparable between the two groups. No significant differences were observed in the intake of oral rehydration solution or stool output between the groups. The mean ± SD of total stool output (g kg−1 ) was 532 ± 476 vs 479 ± 354 and the duration (h) of diarrhoea was 108 ± 68 vs 103 ± 53 in the folic acid vs placebo group, respectively. The findings, therefore, should have a positive influence on preventing the inappropriate use of folic acid in acute diarrhoea. 相似文献
60.