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951.
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Community engagement with genetics: public perceptions and expectations about genetics research 下载免费PDF全文
Holly Etchegary PhD Jane Green PhD Patrick Parfrey MD Catherine Street BPharm Daryl Pullman PhD 《Health expectations》2015,18(5):1413-1425
Background
Knowledge of molecular biology and genomics continues to expand rapidly, promising numerous opportunities for improving health. However, a key aspect of the success of genomic medicine is related to public understanding and acceptance.Design
Using community consultations and an online survey, we explored public attitudes and expectations about genomics research.Results
Thirty‐three members of the general public in Newfoundland, Canada, took part in the community sessions, while 1024 Atlantic Canadians completed the online survey. Overall, many participants noted they lacked knowledge about genetics and associated research and took the opportunity to ask numerous questions throughout sessions. Participants were largely hopeful about genomics research in its capacity to improve health, not only for current residents, but also for future generations. However, they did not accept such research uncritically, and a variety of complex issues and questions arose during the community consultations and were reflected in survey responses.Discussion
With the proliferation of biobanks and the rapid pace of discoveries in genomics research, public support will be crucial to realize health improvements. If researchers can engage the public in regular, transparent dialogue, this two‐way communication could allow greater understanding of the research process and the design of efficient and effective genetic health services, informed by the public that will use them. 相似文献953.
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Elena Makovac Sarah N Garfinkel Andrea Bassi Barbara Basile Emiliano Macaluso Mara Cercignani Giovanni Calcagnini Eugenio Mattei Daniela Agalliu Pietro Cortelli Carlo Caltagirone Marco Bozzali Hugo Critchley 《Neuropsychopharmacology》2015,40(7):1649-1658
Autonomic nervous system activity is an important component of human emotion. Mental processes influence bodily physiology, which in turn feeds back to influence thoughts and feelings. Afferent cardiovascular signals from arterial baroreceptors in the carotid sinuses are processed within the brain and contribute to this two-way communication with the body. These carotid baroreceptors can be stimulated non-invasively by externally applying focal negative pressure bilaterally to the neck. In an experiment combining functional neuroimaging (fMRI) with carotid stimulation in healthy participants, we tested the hypothesis that manipulating afferent cardiovascular signals alters the central processing of emotional information (fearful and neutral facial expressions). Carotid stimulation, compared with sham stimulation, broadly attenuated activity across cortical and brainstem regions. Modulation of emotional processing was apparent as a significant expression-by-stimulation interaction within left amygdala, where responses during appraisal of fearful faces were selectively reduced by carotid stimulation. Moreover, activity reductions within insula, amygdala, and hippocampus correlated with the degree of stimulation-evoked change in the explicit emotional ratings of fearful faces. Across participants, individual differences in autonomic state (heart rate variability, a proxy measure of autonomic balance toward parasympathetic activity) predicted the extent to which carotid stimulation influenced neural (amygdala) responses during appraisal and subjective rating of fearful faces. Together our results provide mechanistic insight into the visceral component of emotion by identifying the neural substrates mediating cardiovascular influences on the processing of fear signals, potentially implicating central baroreflex mechanisms for anxiolytic treatment targets. 相似文献
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Philipp J. Hohensinner Julia Mayer Julia Kirchbacher Julia Kral-Pointner Barbara Thaler Christoph Kaun Lena Hell Patrick Haider Marion Mussbacher Johannes A. Schmid Stefan Stojkovic Svitlana Demyanets Michael B. Fischer Kurt Huber Katharina Woran Christian Hengstenberg Walter S. Speidl Rudolf Oehler Ingrid Pabinger Johann Wojta 《Haematologica》2021,106(2):454
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Tatiana Raskovalova Patrick B. Deegan Pramod K. Mistry Elena Pavlova Ruby Yang Ari Zimran Juliette Berger Celine Bourgne Bruno Pereira Jose Labarere Marc G. Berger 《Haematologica》2021,106(2):437
Chitotriosidase activity and CCL18 concentration are interchangeably used for monitoring Gaucher disease (GD) activity, together with clinical assessment. However, comparative studies of these two biomarkers are scarce and of limited sample size. The aim of this systematic review with meta-analysis of individual participant data (IPD) was to compare the accuracy of chitotriosidase activity and CCL18 concentration for assessing type I GD severity. We identified cross-sectional and prospective cohort studies by searching Medline, EMBASE, and CENTRAL from January 1995 to June 2017, and by contacting research groups. The primary outcome was a composite of liver volume >1.25 multiple of normal (MN), spleen volume >5 MN, hemoglobin concentration <11 g/dL, and platelet count <100x109/L. Overall, IPD included 1,109 observations from 334 patients enrolled in nine primary studies, after excluding 111 patients with undocumented values and 18 patients with deficient chitotriosidase activity. IPD were unavailable for 14 eligible primary studies. The primary outcome was associated with a 5.3-fold (95% Confidence Interval [CI]: 4.2-6.6) and 3.0-fold (95% CI: 2.6-3.6) increase of the geometric mean for chitotriosidase activity and CCL18 concentration, respectively. The corresponding areas under the receiver operating characteristics curves were 0.82 and 0.84 (summary difference, 0.02, 95% CI: -0.02 to 0.05). The addition of chitotriosidase activity did not improve the accuracy of the CCL18 concentration. Estimates remained robust in the sensitivity analysis and consistent across subgroups. Neither the chitotriosidase activity nor the CCL18 concentration varied significantly according to a recent history of bone events among 97 patients. In conclusion, the CCL18 concentration is as accurate as chitotriosidase activity in assessing hematological and visceral parameters of GD severity and can be measured in all GD patients. This meta-analysis supports the use of CCL18 rather than chitotriosidase activity for monito-ring GD activity in routine practice. 相似文献
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Gallogly Susan Fujisawa Takeshi Hung John D. Brittan Mairi Skinner Elizabeth M. Mitchell Andrew J. Medine Claire Luque Neus Zodda Erika Cascante Marta Hadoke Patrick W. Mills Nicholas L. Tura-Ceide Olga 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》2021,35(6):1281-1290
Cardiovascular Drugs and Therapy - Endothelial dysfunction is central to the pathogenesis of acute coronary syndrome. The study of diseased endothelium is very challenging due to inherent... 相似文献
960.
Singh Ayesha Coulter Amanda R. Trainor Patrick J. Singam Narayana Sarma V. Aladili Bahjat N. Amraotkar Alok R. Owolabi Ugochukwu S. DeFilippis Andrew P. 《Journal of thrombosis and thrombolysis》2021,51(1):120-128
Journal of Thrombosis and Thrombolysis - Platelet activation and subsequent aggregation is a vital component of atherothrombosis resulting in acute myocardial infarction. Therefore, quantifying... 相似文献