全文获取类型
收费全文 | 36084篇 |
免费 | 2272篇 |
国内免费 | 109篇 |
专业分类
耳鼻咽喉 | 321篇 |
儿科学 | 1165篇 |
妇产科学 | 1013篇 |
基础医学 | 4945篇 |
口腔科学 | 616篇 |
临床医学 | 5919篇 |
内科学 | 6557篇 |
皮肤病学 | 598篇 |
神经病学 | 3442篇 |
特种医学 | 606篇 |
外科学 | 3123篇 |
综合类 | 403篇 |
一般理论 | 55篇 |
预防医学 | 4510篇 |
眼科学 | 469篇 |
药学 | 2113篇 |
中国医学 | 68篇 |
肿瘤学 | 2542篇 |
出版年
2023年 | 181篇 |
2022年 | 337篇 |
2021年 | 775篇 |
2020年 | 459篇 |
2019年 | 779篇 |
2018年 | 896篇 |
2017年 | 619篇 |
2016年 | 648篇 |
2015年 | 834篇 |
2014年 | 1173篇 |
2013年 | 1780篇 |
2012年 | 2653篇 |
2011年 | 2803篇 |
2010年 | 1529篇 |
2009年 | 1287篇 |
2008年 | 2541篇 |
2007年 | 2545篇 |
2006年 | 2564篇 |
2005年 | 2386篇 |
2004年 | 2305篇 |
2003年 | 2186篇 |
2002年 | 2041篇 |
2001年 | 220篇 |
2000年 | 151篇 |
1999年 | 298篇 |
1998年 | 412篇 |
1997年 | 367篇 |
1996年 | 326篇 |
1995年 | 279篇 |
1994年 | 271篇 |
1993年 | 253篇 |
1992年 | 166篇 |
1991年 | 137篇 |
1990年 | 133篇 |
1989年 | 128篇 |
1988年 | 106篇 |
1987年 | 112篇 |
1986年 | 90篇 |
1985年 | 107篇 |
1984年 | 155篇 |
1983年 | 157篇 |
1982年 | 194篇 |
1981年 | 167篇 |
1980年 | 159篇 |
1979年 | 93篇 |
1978年 | 74篇 |
1977年 | 81篇 |
1976年 | 60篇 |
1975年 | 53篇 |
1974年 | 68篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
992.
E Omoyinmi R Hamaoui A Pesenacker K Nistala H Moncrieffe S Ursu LR Wedderburn P Woo 《Rheumatology (Oxford, England)》2012,51(10):1881-1886
Objective. The role of the adaptive immune system has not been explored in detail compared with the innate immune system in systemic JIA (sJIA) pathogenesis. The aim of this study was to examine the phenotype of circulating peripheral blood CD4(+) T-cell subpopulations in a cross-sectional study of sJIA patients during disease remission on medication and during acute flare of the disease. Methods. Flow cytometry was used to examine the phenotype and cytokine production of IFNγ-, IL-4- and IL-17-producing CD4(+) T cells in the peripheral blood of 10 sJIA patients with active disease, 9 sJIA with inactive disease, 14 JIA patients with oligoarticular onset, 10 adult control subjects and 10 age-matched control subjects. In parallel, we examined the proportion of FoxP3(+) Tregs. Results. IFNγ- and IL-17-producing CD4(+) T cells and IL-17-producing CD3(+)CD4(-) T cells were present at higher proportions in the peripheral blood of sJIA patients, irrespective of their disease status. Our data also confirm the known increase of the proportions of IFNγ-producing Th1 cells with increasing age and suggest an increase with age in the IL-17-producing CD4(+) T-cell population. Conclusion. This study is the first to describe significantly higher proportions of Th1 and Th17 T helper cell subsets in the peripheral blood of sJIA patients. These proinflammatory cells may play a pathogenic role in sJIA. Our data also emphasize the importance of using paediatric age-matched control subjects when evaluating the T-cell cytokine profile in JIA. 相似文献
993.
994.
Rodríguez-Carrio J Prado C de Paz B López P Gómez J Alperi-López M Ballina-García FJ Suárez A 《Rheumatology (Oxford, England)》2012,51(10):1775-1784
Objective. The aim of this study was to investigate the endothelial progenitor cell population in SLE and early RA patients and its potential relationships with disease features and cytokine serum levels. Methods. Endothelial progenitor cells (EPCs), mature EPCs (mEPCs) and endothelial cells (ECs) were measured in peripheral blood samples from 83 SLE and 85 early RA patients and 39 healthy controls by flow cytometry on the basis of CD34, VEGF receptor 2 and CD133 expression. Serum levels of IL-1β, IL-6, IL-8, IL-17, VEGF-A, IFN-α, TGF-β and GM-CSF were quantified by immunoassays. Clinical and immunological data were obtained by reviewing clinical histories. Results. Circulating EPCs were increased in SLE but not in early RA patients associated with an enhanced CD34(+) bone marrow-progenitor cell release but unrelated to disease features. The amount of mEPCs, however, was significantly higher in SLE patients presenting anti-SSA/SSB antibodies and/or malar rash, whereas the presence of specific autoantibodies was associated with EC counts in early RA and SLE patients. As expected, most cytokines tested were altered in both diseases but, interestingly, IFN-α levels, and to a lesser extent IL-6 and IL-1β, were associated with CD133 loss and increased mEPC number, whereas VEGF and TGF-β seem to exert an opposite effect. Conclusion. Our results show that high IFN-α levels and/or the presence of disease-specific antibodies may identify a group of SLE patients with increased mEPC and EC counts, and consequently probably defective endothelial repair, thus supporting their use as surrogate biomarkers of endothelial damage and high cardiovascular risk. 相似文献
995.
996.
Garg S Chaves SS Pérez A D'Mello T Gershman K Meek J Yousey-Hindes K Arnold KE Farley MM Tengelsen L Ryan P Sharangpani R Lynfield R Morin C Baumbach J Hancock EB Zansky S Bennett NM Fowler B Bradley K Thomas A Cooper T Schaffner W Boulton R Finelli L Fry AM 《Clinical infectious diseases》2012,55(3):e18-e21
Influenza antiviral treatment is recommended for all persons hospitalized with influenza virus infection. During the 2010-2011 influenza season, antiviral treatment of children and adults hospitalized with laboratory-confirmed influenza declined significantly compared with treatment during the 2009 pandemic (children, 56% vs 77%; adults, 77% vs 82%; both P < .01). 相似文献
997.
Bergeron A Porcher R Raffoux E Sulahian A Ribaud P 《Clinical infectious diseases》2012,55(3):475-6; author reply 476-7
998.
King LA Nogareda F Weill FX Mariani-Kurkdjian P Loukiadis E Gault G Jourdan-DaSilva N Bingen E Macé M Thevenot D Ong N Castor C No?l H Van Cauteren D Charron M Vaillant V Aldabe B Goulet V Delmas G Couturier E Le Strat Y Combe C Delmas Y Terrier F Vendrely B Rolland P de Valk H 《Clinical infectious diseases》2012,54(11):1588-1594
999.
1000.