全文获取类型
收费全文 | 274篇 |
免费 | 12篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 9篇 |
妇产科学 | 18篇 |
基础医学 | 25篇 |
口腔科学 | 9篇 |
临床医学 | 33篇 |
内科学 | 73篇 |
皮肤病学 | 3篇 |
神经病学 | 4篇 |
特种医学 | 57篇 |
外科学 | 15篇 |
综合类 | 12篇 |
预防医学 | 10篇 |
眼科学 | 1篇 |
药学 | 8篇 |
中国医学 | 3篇 |
肿瘤学 | 5篇 |
出版年
2019年 | 3篇 |
2017年 | 3篇 |
2016年 | 5篇 |
2015年 | 7篇 |
2014年 | 7篇 |
2013年 | 12篇 |
2012年 | 15篇 |
2011年 | 2篇 |
2010年 | 5篇 |
2009年 | 6篇 |
2008年 | 6篇 |
2007年 | 10篇 |
2006年 | 4篇 |
2005年 | 4篇 |
2004年 | 2篇 |
2003年 | 5篇 |
2002年 | 4篇 |
2001年 | 5篇 |
2000年 | 2篇 |
1999年 | 3篇 |
1998年 | 20篇 |
1997年 | 13篇 |
1996年 | 12篇 |
1995年 | 14篇 |
1994年 | 7篇 |
1993年 | 16篇 |
1992年 | 2篇 |
1991年 | 4篇 |
1990年 | 3篇 |
1989年 | 9篇 |
1988年 | 5篇 |
1987年 | 5篇 |
1986年 | 4篇 |
1985年 | 5篇 |
1984年 | 2篇 |
1983年 | 2篇 |
1982年 | 3篇 |
1981年 | 2篇 |
1980年 | 7篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1976年 | 4篇 |
1975年 | 2篇 |
1959年 | 2篇 |
1958年 | 2篇 |
1957年 | 6篇 |
1956年 | 4篇 |
1955年 | 4篇 |
1954年 | 5篇 |
1950年 | 2篇 |
排序方式: 共有287条查询结果,搜索用时 0 毫秒
81.
The purpose of this study was to quantitate the number and labeling index of monoclonal plasma cells in the blood of patients with newly diagnosed multiple myeloma (MM) to learn if these values were independent prognostic factors for survival. Patients were candidates for this study if they had untreated myeloma requiring therapy, were evaluated at our institution between 1984 and 1993, and had a sample of blood analyzed with a sensitive immunofluorescence technique for monoclonal plasma cells and the blood B-cell labelling index (BLI). The % blood monoclonal plasma cells (%BPC) and the BLI were analyzed along with stage, marrow plasma cell LI, % marrow plasma cells, calcium, creatinine, albumin, beta-2-microglobulin, and C-reactive protein as univariate and multivariate factors for survival. Eighty percent of the 254 patients accrued to this study had monoclonal BPC detected. The median % BPC was 6% and 57% (144 of 254) of patients had a high number (> or = 4%). Patients with > or = 4% BPC had a median survival of 2.4 years vs 4.4 years for those with < 4% BPC (P < .001). The BLI was also prognostic (P = .008). In a multivariate analysis, the % BPC, age, albumin, stage, marrow plasma cell LI, and the BLI were independent factors for survival. The %BPC and the marrow plasma cell LI best separated the group into low, intermediate, and high risk myeloma with median survivals of 52, 35, and 26 months, respectively. Patients with high %BPC were less likely to have lytic bone disease from their MM (P = .002). The %BPC and the BLI are independent prognostic factors for survival and are useful in identifying patients as low, intermediate, and high risk. Clonal cells in the blood should be quantified in future clinical trials for myeloma. 相似文献
82.
Aplastic anemia and myelogenous leukemia are prominent pathologic effects in beagles exposed to continuous, daily, low-dose gamma irradiation. In the present work, granulocyte reserves and related mobilization functions have been sequentially assessed by the endotoxin stress assay during the preclinical and clinical phases of these hemopoietic disorders. Characteristic patterns of granulocyte reserve mobilization are described that reflect given stages of pathologic progression. For radiation-induced leukemia, a five stage pattern has been proposed. In contrast, a simple pattern of progressive, time- dependent contraction of granulocyte reserves and mobilization capacity was noted in the development of terminal aplastic anemia. Early preclinical phases of radiation-induced leukemia appear to involve an extensive depletion of the granulocyte reserves ((phase I) during the first approximately 200 days of exposure followed by a partial renewal of the reserves and associated mobilization functions approximately 200 and 400 days (phase II). Sustained, subnormal granulocyte mobilizations (phase III) following endotoxin stress typify the responses of dogs during the intermediate phase, whereas late preclinical, preleukemic stages (phase IV) are characterized by a further expansion of the reserves and in the mobilization capacities, particularly of the less mature granulocytes. Such late alterations in the pattern of granulocyte mobilization, together with other noted cellular aberrancies in the peripheral blood and marrow, appear to indicate leukemia (phase V) onset. 相似文献
83.
Surendran Sabapathy Marc F Awater Donald A Schneider Rebecca A Kingsley Maria TE Hopman Norman R Morris 《INT J CHRONIC OBSTR》2006,1(1):73-81
We compared exercise capacity (peak O2 uptake; V̇O2peak) and lower limb vasodilatory capacity in 9 patients with moderate COPD (FEV1 52.7 ± 7.6% predicted) and 9 age-matched healthy control subjects. V̇O2peak was measured via open circuit spirometry during incremental cycling. Calf blood flow (CBF) measurements were obtained at rest and after 5 minutes of ischemia using venous occlusion plethysmography. While V̇O2peak was significantly lower in the COPD patients (15.8 ± 3.5 mL·kg−1·min−1) compared with the control group (25.2 ± 3.5 mL·kg−1·min−1), there were no significant differences between groups in peak CBF or peak calf conductance measured 7 seconds post-ischemia. V̇O2peak was significantly correlated with peak CBF and peak conductance in the control group, whereas no significant relationship was found between these variables in the COPD group. However, the rate of decay in blood flow following ischemia was significantly slower (p < 0.05) for the COPD group (−0.036 ± 0.005 mL·100 mL−1·min−1·s−1) when compared with controls (−0.048 ± 0.015 mL·100 mL−1·min−1·s−1). The results suggest that the lower peak exercise capacity in patients with moderate COPD is not related to a loss in leg vasodilatory capacity. 相似文献
84.
ANNELINE S.J.M. TE RIELE M.D. CYNTHIA A. JAMES Ph.D. BINU PHILIPS M.D. NEDA RASTEGAR M.D. ADITYA BHONSALE M.D. JUDITH A. GROENEWEG M.D. BRITTNEY MURRAY M.S. CRYSTAL TICHNELL M.G.C. DANIEL P. JUDGE M.D. JEROEN F. VAN DER HEIJDEN M.D. Ph.D. MAARTEN J.M. CRAMER M.D. Ph.D. BIRGITTA K. VELTHUIS M.D. Ph.D. DAVID A. BLUEMKE M.D. Ph.D. STEFAN L. ZIMMERMAN M.D. IHAB R. KAMEL M.D. Ph.D. RICHARD N.W. HAUER M.D. Ph.D. HUGH CALKINS M.D. HARIKRISHNA TANDRI M.D. 《Journal of cardiovascular electrophysiology》2013,24(12):1311-1320
85.
86.
CHARLES C. TE M.D. STAVROS STAVRAKIS M.D. PEDRO LOZANO M.D. DWIGHT REYNOLDS M.D. F.H.R.S. 《Journal of cardiovascular electrophysiology》2013,24(2):224-226
Apparent Acute Reversible Right Ventricular Pacing‐Induced Left Ventricular Dysfunction . We report the case of a 70‐year‐old Caucasian male with a dual chamber (right atrium/right ventricle) pacemaker implanted for sinus node dysfunction and not pacemaker (PM) dependent who was found to have an apparent acute worsening of left ventricular (LV) function with right ventricular (RV) apical pacing caused by the mode switch to VVI pacing as battery depletion occurred. LV dysfunction resolved immediately with RV pacing turned off. To our knowledge, this is the first report of this phenomenon. (J Cardiovasc Electrophysiol, Vol. 24, pp. 224‐226, February 2013) 相似文献
87.
PHILIPPE BRUNEL M.D. ASHOK TIROUVANZIAM M.D. ROBERT GROSSETÊTE M.D. DOMINIQUE CROCHET M.D. 《Journal of interventional cardiology》2000,13(2):117-121
This study reports our preliminary experience of percutaneous coronary angioplasty with low dose heparin and immediate withdrawal of the femoral sheath. After selection, 120 patients underwent a procedure with a low dose of heparin (4,300 ± 700 IU). A total of 120 of 123 lesions (97.6%) were treated successfully by the femoral route. There were no major cardiac complications during the procedure and hospital stay. Patients were allowed to be ambulant 6 hours after the procedure. No significant bleeding occurred. There was no need for surgery relative to the approach route nor for blood transfusion. The use of low dose heparin and immediate withdrawal of the femoral sheath did not increase the risk of coronary angioplasty in these selected patients. The period of bed confinement was shortened and the patients were ambulant earlier, leading to a reduction in their hospital stay with no increase in costs. 相似文献
88.
目的:评价补肺健脾益肾方治疗老年慢性阻塞性肺疾病(COPD)稳定期的疗效及对患者外周血T淋巴细胞亚群、BODE指数及生活质量的影响.方法:将80例中医辨证为肺脾肾气虚型COPD稳定期患者随机分组,对照组(40例)仅采取常规西医治疗,而观察组(40例)在常规西医治疗的基础上联合补肺健脾益肾汤,治疗8周后比较临床疗效及患者外周血T淋巴细胞亚群、BODE指数及生活质量的变化.结果:经治疗后观察组BODE指数及BMI积分、FEV1积分、MMRC积分、6MWT积分均较对照组明显减少,差异具有统计学意义(P<0.05);经治疗后观察组CD3+、CD4+及CD4+/CD8+较对照组明显升高,CD8 +水平较对照组明显降低,差异具有统计学意义(P<0.05);两组经治疗后肺功能指标FEV1和FEV1/FVC均较治疗前有明显改善,差异具有统计学意义(P<0.05);两组治疗后SGRQ评分均较治疗前明显降低,但观察组治疗后SGRQ评分明显低于对照组,差异具有统计学意义(P<0.05).结论:补肺健脾益肾方用于老年COPD稳定期治疗可改善患者肺功能及BODE指数,提高生活质量,增强细胞免疫功能. 相似文献
89.
90.
目的 :诱导出贯叶金丝桃的愈伤组织 ,并确定其中含有金丝桃素。方法 :在不同条件下采用组织培养技术 ,进行贯叶金丝桃的愈伤组织诱导研究 ,用HPLC方法确定其中含有的金丝桃素。结果和结论 :最佳诱导条件是MS基本培养基加入生长调节物质 2 ,4 D(4μg·L- 1 )和 6 BA(0 .2 μg·L- 1 )。叶腋等分生组织较多的部位易于诱导愈伤组织。诱导出的愈伤组织 ,经HPLC方法确定其含金丝桃素 相似文献