全文获取类型
收费全文 | 741篇 |
免费 | 34篇 |
国内免费 | 28篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 29篇 |
妇产科学 | 31篇 |
基础医学 | 94篇 |
口腔科学 | 7篇 |
临床医学 | 105篇 |
内科学 | 185篇 |
皮肤病学 | 8篇 |
神经病学 | 26篇 |
特种医学 | 63篇 |
外科学 | 69篇 |
综合类 | 18篇 |
预防医学 | 36篇 |
眼科学 | 11篇 |
药学 | 89篇 |
肿瘤学 | 29篇 |
出版年
2023年 | 3篇 |
2022年 | 5篇 |
2021年 | 20篇 |
2020年 | 13篇 |
2019年 | 11篇 |
2018年 | 15篇 |
2017年 | 12篇 |
2016年 | 17篇 |
2015年 | 19篇 |
2014年 | 24篇 |
2013年 | 31篇 |
2012年 | 54篇 |
2011年 | 38篇 |
2010年 | 29篇 |
2009年 | 37篇 |
2008年 | 39篇 |
2007年 | 52篇 |
2006年 | 27篇 |
2005年 | 27篇 |
2004年 | 31篇 |
2003年 | 22篇 |
2002年 | 22篇 |
2001年 | 15篇 |
2000年 | 14篇 |
1999年 | 18篇 |
1998年 | 19篇 |
1997年 | 20篇 |
1996年 | 18篇 |
1995年 | 20篇 |
1994年 | 15篇 |
1993年 | 22篇 |
1992年 | 4篇 |
1991年 | 8篇 |
1990年 | 10篇 |
1989年 | 13篇 |
1988年 | 8篇 |
1987年 | 4篇 |
1986年 | 4篇 |
1985年 | 7篇 |
1984年 | 6篇 |
1983年 | 5篇 |
1982年 | 4篇 |
1981年 | 3篇 |
1980年 | 2篇 |
1979年 | 3篇 |
1978年 | 2篇 |
1976年 | 2篇 |
1971年 | 2篇 |
1940年 | 1篇 |
1939年 | 1篇 |
排序方式: 共有803条查询结果,搜索用时 15 毫秒
791.
792.
793.
Genetic and cellular basis of cerebral cavernous malformations: implications for clinical management
S Bacigaluppi SF Retta S Pileggi M Fontanella L Goitre L Tassi A La Camera A Citterio MC Patrosso G Tredici S Penco 《Clinical genetics》2013,83(1):7-14
Bacigaluppi S, Retta SF, Pileggi S, Fontanella M, Goitre L, Tassi L, La Camera A, Citterio A, Patrosso MC, Tredici G, Penco S. Genetic and cellular basis of cerebral cavernous malformations: implications for clinical management. Cerebral cavernous malformations (CCMs) are a diffuse cerebrovascular disease affecting approximately 0.5% of the population. A CCM is characterized by abnormally enlarged and leaky capillaries arranged in mulberry‐like structures with no clear flow pattern. The lesion might predispose to seizures, focal neurological deficits or fatal intracerebral hemorrhage. However, a CCM can also remain neurologically silent. It might either occur sporadically or as an inherited disorder with incomplete penetrance and variable expressivity. Due to advances in imaging techniques, the incidence of CCM diagnoses are increasing, and the patient must be managed on a multidisciplinary basis: genetic counselling, treatment if needed, and follow‐up. Advances have been made using radiological and pathological correlates of CCM lesions adding to the accumulated knowledge of this disease, although management of these patients is very variable among centers. This review is aimed at providing an update in genetic and molecular insights of this condition. Included are implications for genetic counselling, and possible approaches to prevention and treatment that derive from the understanding of pathogenetic mechanisms. 相似文献
794.
Hairy cell leukemia: a tumor of pre-plasma cells 总被引:7,自引:0,他引:7
Monoclonal antibodies defining B-, T-, and myeloid-restricted cell surface antigens were used to characterize the lineage and state of differentiation of tumor cells isolated from 22 patients with hairy cell leukemia (HCL). These tumors were shown to be of B lineage because they strongly expressed the B cell-restricted antigens B1 and B4 and lacked T cell- and monocyte-restricted antigens. Moreover, the strong expression of the plasma cell-associated PCA-1 antigen on the majority of hairy cells suggested that these tumors correspond to later stages of B cell ontogeny. Dual fluorescence experiments further confirmed that HCL splenocytes that coexpressed B1 and PCA-1 demonstrated both the morphology and tartrate-resistant acid phosphatase positivity of hairy cells. The observation that some hairy cells either spontaneously produce immunoglobulin (Ig) or could be induced to proliferate and secrete Ig provides complementary support for the view that HCL is a pre-plasma cell tumor. However, staining of hairy cells with anti-IL2R1 monoclonal antibody, which is directed to the T cell growth factor receptor and/or with the anti-Mo1 reagent, directed to C3bi complement receptor, distinguish these cells from currently identified B cells. 相似文献
795.
796.
797.
Evan P. Pasha Alex C. Birdsill Stephanie Oleson Andreana P. Haley Hirofumi Tanaka 《Brain imaging and behavior》2018,12(6):1658-1668
Metabolic syndrome (MetS) adversely affects the vasculature and cerebral white matter (CWM) integrity. Arterial stiffening has been associated with diminished CWM integrity. Physical activity (PA) can ameliorate components of MetS and subsequently affect arterial stiffening and CWM integrity. Our aim was to determine the role of PA on mitigating the adverse influence of MetS on arterial stiffness and CWM integrity. In a cross-sectional study design, sixty-six middle-aged adults (40–62 years) composed of 18 sedentary MetS (Sed MetS), 21 physically active MetS (Active MetS), and 27 healthy individuals absent of MetS risk factors were studied. Carotid artery stiffness was assessed via simultaneous ultrasound and tonometry. CWM integrity was measured using diffusion tensor imaging (DTI) through metrics of fractional anisotropy (FA) and mean diffusivity (MD). Carotid β-stiffness index in Active MetS was lower than Sed MetS but was not different from Healthy controls (6.6?±?1.5, 7.7?±?2.1, and 5.6?±?1.6 au, p?=?0.001). CWM integrity was significantly greater in Active MetS subjects compared to Sed MetS subjects but statistically equal to Healthy controls in the anterior limb of the internal capsule, and splenium of the corpus callosum, uncinate fasciculus, and superior corona radiata (all p?<?0.05). Middle-aged individuals with MetS who habitually perform PA demonstrated lower arterial stiffness and more favorable CWM integrity than their sedentary peers, indicating that PA may be effective in mitigating the adverse effects of MetS on the vasculature and brain at midlife. 相似文献
798.
799.
Ann Tran Matthew T. S. Yan Donald R. Branch Megan Blacquiere Nicolas Pineault Roya Pasha Gwen Clarke 《Transfusion》2023,63(4):877-882
Background
The Jr blood group system includes a single, high-prevalence antigen, Jra, encoded by the ABCG2 gene. The impact of anti-Jra in pregnancy is variable, ranging from no clinical effect to severe anemia including some fetal deaths. Case reports have postulated that anti-Jra mediated fetal anemia is poorly hemolytic, suggesting other mechanisms of anemia may be involved.Study Design and Methods
We describe the case of severe anti-Jra mediated fetal anemia. At Canadian Blood Services laboratories, maternal anti-Jra was tested for phagocytic activity via a monocyte monolayer assay (MMA) and erythroid suppression via inhibition of burst forming unit-erythroid (BFU-E) colony formation assays. The New York Blood Center sequenced exons 4 and 7 of the ABCG2 gene.Results and Discussion
Sequencing of exons 4 and 7 of the ABCG2 gene revealed maternal compound heterozygosity for two nonsense mutations at exon 7 (c.706 C > T and c.784G > T). Fetal sequencing revealed the c.706C > T polymorphism. The MMA showed a borderline phagocytic index (around the cutoff of five for both donor segments tested [5 ± 1 and 7 ± 3]). The BFU-E colony formation inhibition assay suggested a dose-dependent inhibition of BFU-E colony formation with inhibition percentages of 4%, 11%, and 43% at maternal serum concentrations of 2%, 5%, and 10%, respectively. Our findings support the hypothesis that anti-Jra may impair erythropoiesis leading to clinically significant fetal/neonatal anemia. A referral to maternal fetal medicine is recommended if anti-Jra is detected in pregnancy, regardless of the titer. 相似文献800.
Dmitry Antukh Dmitry Shchekochikhin Teona Rosina Elena Mershina Olga Larina Sergey Pasha Elena Zaklyazminskaya Valentin Sinitsyn Sergey Moiseev 《Clinical Case Reports》2021,9(8)
Common diagnostic approach in patients with suspected cardiac amyloidosis includes cardiac magnetic resonance imaging and scintigraphy. We report the first clinical case of false‐positive results of scintigraphy in a patient with Danon disease. 相似文献