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101.
Konstantina Papalexopoulou Athanasios Chalkias Ioannis Dontas Paraskevi Pliatsika Charalampos Giannakakos Panagiotis Papapanagiotou Afroditi Aggelina Theodoros Moumouris Georgios Papadopoulos Theodoros Xanthos 《Heart & lung : the journal of critical care》2014
Objectives
To examine whether education and age affect skill acquisition and retention in lay rescuers after a European Resuscitation Council (ERC) CPR/AED course.Background
Because of the importance of bystander CPR/AED skills in the setting of cardiac arrest, acquisition and retention of resuscitation skills has gained a great amount of interest.Methods
The ERC CPR/AED course format for written and practical evaluation was used. Eighty lay people were trained and evaluated at the end of the course, as well as at one, three, and six months.Results
Retention of CPR/AED skills improved over time, recording the lowest practical scores at one month after initial training and the lowest written scores at initial training. In practical evaluation scores, when examined longitudinally, age presented a significant adverse effect and higher background education presented a non-significant positive effect. Moreover, regarding written evaluation scores, when examined longitudinally, education presented a significant positive effect while age did not significantly correlate with written scores.Conclusions
Education and age affected retention of CPR/AED skills in lay rescuers. Also, our results suggest that the ERC CPR/AED course format may be poorly designed to discriminate between participants with different levels of practical and written resuscitation skills and merit a thorough investigation in future studies. 相似文献102.
Magdalena Kraft Macarena Pia Knop Jean-Marie Renaudin Kathrin Scherer Hofmeier Claudia Pföhler Maria Beatrice Bilò Roland Lang Regina Treudler Nicola Wagner Thomas Spindler Jonathan O'B Hourihane Ioana Maris Alice Koehli Andrea Bauer Lars Lange Sabine Müller Nikolaos G. Papadopoulos Bettina Wedi Anne Moeser Luis F. Ensina Montserrat Fernandez-Rivas Ewa Cichocka-Jarosz George Christoff Blanca E. Garcia Iwona Poziomkowska-Gęsicka Victoria Cardona Tihomir B. Mustakov Uta Rabe Vera Mahler Linus Grabenhenrich Sabine Dölle-Bierke Margitta Worm The Network for Online Registration of Anaphylaxis 《Allergy》2020,75(4):901-910
103.
Ioana Agache Jessica Beltran Cezmi Akdis Mubeccel Akdis Carlos Canelo-Aybar Giorgio Walter Canonica Thomas Casale Tomas Chivato Jonathan Corren Stefano Del Giacco Thomas Eiwegger Davide Firinu James E. Gern Eckard Hamelmann Nicola Hanania Mika Mäkelä Irene Hernández-Martín Parameswaran Nair Liam O'Mahony Nikolaos G. Papadopoulos Alberto Papi Hae-Sim Park Luis Pérez de Llano Margarita Posso Claudio Rocha Santiago Quirce Joaquin Sastre Mohamed Shamji Yang Song Corinna Steiner Jurgen Schwarze Pablo Alonso-Coello Oscar Palomares Marek Jutel 《Allergy》2020,75(5):1023-1042
Five biologicals have been approved for severe eosinophilic asthma, a well-recognized phenotype. Systematic reviews (SR) evaluated the efficacy and safety of benralizumab, dupilumab, mepolizumab, omalizumab and reslizumab (alphabetical order) compared to standard of care for severe eosinophilic asthma. PubMed, Embase and Cochrane Library were searched to identify RCTs and health economic evaluations, published in English. Critical and important asthma-related outcomes were evaluated for each of the biologicals. The risk of bias and the certainty of the evidence were assessed using GRADE. 19 RCTs (three RCTs for benralizumab, three RCTs for dupilumab, three RCTs for mepolizumab, five RCTs for omalizumab and five RCTs for reslizumab), including subjects 12 to 75 years old (except for omalizumab including also subjects 6-11 years old), ranging from 12 to 56 weeks were evaluated. All biologicals reduce exacerbation rates with high certainty of evidence: benralizumab incidence rate ratio (IRR) 0.53 (95% CI 0.39 to 0.72), dupilumab (IRR) 0.43 (95% CI 0.32 to 0.59), mepolizumab IRR 0.49 (95% CI 0.38 to 0.66), omalizumab (IRR) 0.56 (95% CI 0.40 to 0.77) and reslizumab (IRR) 0.46 (95% CI 0.37 to 0.58). Benralizumab, dupilumab and mepolizumab reduce the daily dose of oral corticosteroids (OCS) with high certainty of evidence. All evaluated biologicals probably improve asthma control, QoL and FEV1, without reaching the minimal important difference (moderate certainty). Benralizumab, mepolizumab and reslizumab slightly increase drug-related adverse events (AE) and drug-related serious AE (low to very low certainty of evidence). The incremental cost-effectiveness ratio per quality-adjusted life year value is above the willingness to pay threshold for all biologicals (moderate certainty). Potential savings are driven by decrease in hospitalizations, emergency and primary care visits. There is high certainty that all approved biologicals reduce the rate of severe asthma exacerbations and for benralizumab, dupilumab and mepolizumab for reducing OCS. There is moderate certainty for improving asthma control, QoL, FEV1. More data on long-term safety are needed together with more efficacy data in the paediatric population. 相似文献
104.
105.
106.
M. Jutel N. G. Papadopoulos H. Gronlund H.‐J. Hoffman B. Bohle P. Hellings G.‐J. Braunsthal A. Muraro P. Schmid‐Grendelmeier T. Zuberbier I. Agache 《Allergy》2014,69(6):708-718
The majority of patients seeking medical advice for allergic diseases are first seen in a primary care setting. Correct diagnosis with identification of all offending allergens is an absolute prerequisite for appropriate management of allergic disease by the general practitioner. Allergy diagnostic tests recommended for use in primary care are critically reviewed in accordance with the significant workload in a primary care setting. Simplified pathways for recognition and diagnosis of allergic diseases are proposed, that should be further adapted to local (national) conditions. 相似文献
107.
T. Holzhauser L. K. Poulsen M. H. Gowland C. A. Akdis E. N. C. Mills N. Papadopoulos G. Roberts S. Schnadt R. van Ree A. Sheikh S. Vieths the EAACI Food Allergy Anaphylaxis Guidelines Group 《Allergy》2014,69(11):1464-1472
Individuals suffering from IgE‐mediated food allergy usually have to practise life‐long food allergen avoidance. This document aims to provide an overview of recent evidence‐based recommendations for allergen risk assessment and management in the food industry and discusses unmet needs and expectations of the food allergic consumer in that context. There is a general duty of care on the food industry and obligations in European Union legislation to reduce and manage the presence of allergens alongside other food hazards. Current evidence enables quantification of allergen reference doses used to set‐up reliable food safety management plans for some foods. However, further work is required to include a wider variety of foods and to understand the impact of the food matrix as well as additional factors which affect the progression and severity of symptoms as a function of dose. Major concerns have been raised by patients, carers and patient groups about the use of precautionary ‘may contain’ labelling to address the issue of unintended presence of allergens; these therefore need to be reconsidered. New and improved allergen detection methods should be evaluated for their application in food production. There is an urgent requirement for effective communication between healthcare professionals, patient organizations, food industry representatives and regulators to develop a better approach to protecting consumers with food allergies. 相似文献
108.
G. Roberts K. Beyer C. Bindslev‐Jensen V. Cardona A. Dubois G. duToit P. Eigenmann M. Fernandez Rivas S. Halken L. Hickstein A. Høst E. Knol G. Lack M. J. Marchisotto B. Niggemann B. I. Nwaru N. G. Papadopoulos L. K. Poulsen A. F. Santos I. Skypala A. Schoepfer R. Van Ree C. Venter M. Worm B. Vlieg–Boerstra S. Panesar D. de Silva K. Soares‐Weiser A. Sheikh B. K. Ballmer‐Weber C. Nilsson N. W. de Jong C. A. Akdis the EAACI Food Allergy Anaphylaxis Guidelines Group 《Allergy》2014,69(8):1008-1025
Food allergy can result in considerable morbidity, impact negatively on quality of life, and prove costly in terms of medical care. These guidelines have been prepared by the European Academy of Allergy and Clinical Immunology's (EAACI) Guidelines for Food Allergy and Anaphylaxis Group, building on previous EAACI position papers on adverse reaction to foods and three recent systematic reviews on the epidemiology, diagnosis, and management of food allergy, and provide evidence‐based recommendations for the diagnosis and management of food allergy. While the primary audience is allergists, this document is relevant for all other healthcare professionals, including primary care physicians, and pediatric and adult specialists, dieticians, pharmacists and paramedics. Our current understanding of the manifestations of food allergy, the role of diagnostic tests, and the effective management of patients of all ages with food allergy is presented. The acute management of non‐life‐threatening reactions is covered in these guidelines, but for guidance on the emergency management of anaphylaxis, readers are referred to the related EAACI Anaphylaxis Guidelines. 相似文献
109.
110.
Concurrent pleural infiltration by chronic lymphocytic leukemia and adenocarcinoma of unknown primary site diagnosed by effusion cytology
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Ioannis Vrettos M.D. Konstantinos Kamposioras M.D. Stamatios Peridis M.D. Dionisios Aninos M.D. Ph.D. Stella Kazika M.D. Aris Spathis Ph.D. Petros Karakitsos M.D. Ph.D. Angelos Papadopoulos M.D. Ph.D. 《Diagnostic cytopathology》2014,42(2):151-155
Synchronous malignancies in a pleural effusion are rare. A case of concurrent pleural infiltration by adenocarcinoma of unknown primary site and chronic lymphocytic leukemia (CLL) is presented in this case study, which was diagnosed by effusion cytology. Pleural effusion is not an uncommon complication in patients with B‐CLL. Even in a pleural effusion rich in monoclonal lymphocytes, the presence of a second cancer must be excluded because this can be the main cause of mortality. The role of cytology in such cases is of paramount importance. Diagn. Cytopathol. 2014;42:151–155. © 2012 Wiley Periodicals, Inc. 相似文献