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991.
T Niho C Ito Y Shibutani H Hashizume K Yamaguchi 《Nihon yakurigaku zasshi. Folia pharmacologica Japonica》1986,88(4):309-320
The pharmacological properties of MO-8282 (1,2,3,4-tetrahydro-2-methyl-9H-dibenzo [3,4: 6,7]cyclohepta [1,2-c]pyridine maleate) as an antidepressant were investigated. At doses 10 times less than those of amitriptyline, MO-8282 showed similar potencies in reducing the duration of immobility during forced swimming in rats and in potentiating stereotype induced by L-DOPA. Intermediate doses of MO-8282 reduced the duration of immobility during forced swimming, in mice as well, suppressed muricide behavior of olfactory-bulbectomized rats and antagonized clonidine-induced suppression of exploratory activity in mice. MO-8282 moderately antagonized the ptosis but not the hypothermia induced by reserpine in mice. MO-8282 exhibited weak antagonism against the tremor, lacrimation and diarrhea induced by tremorine, but its activity was milder than that of amitriptyline. The uptake of noradrenaline into rat hypothalamic synaptosomes was inhibited by MO-8282 at concentrations 20 times less than equally effective doses of amitriptyline, but the uptake of dopamine or serotonin was unaffected by MO-8282. A single oral administration of MO-8282 at a dose of 30 mg/kg accelerated noradrenaline turnover, but did not affect dopamine and serotonin turnover in the rat brain. MO-8282 strongly inhibited noradrenaline-, histamine- or adenosine-sensitive adenylate cyclase activity of guinea pig brain. Its mode of action differed from that of imipramine, rather resembling that of mianserin. MO-8282 did not affect monoamine oxidase activity of rat liver. These results suggest that the pharmacological characteristics of MO-8282 are different from those of tricyclic antidepressants and rather similar to those of mianserin, but more potent. The results, therefore, indicate that MO-8282 is possibly a novel antidepressant. 相似文献
992.
A brief historical review of the role of female medical students and female physicians in American medicine is presented. The 1985-1986 Council on Resident Education in Obstetrics and Gynecology Residency Data Bank was analyzed for gender distribution. Questionnaire studies were undertaken to study the possible effect of the increasing number of female residents in an obstetrics and gynecology residency program. Queries were sent to current and former residents, the attending staff, and the nursing and anesthesiology staffs. In order to evaluate the national scene, letters were mailed to directors of programs with 20 or more residents. The overall results indicated female residents have a positive effect on residency training. 相似文献
993.
Placement of the nasojejunal feeding tube under direct visual guidance using endoscopy offers an alternative method to those currently used. We found it to be a safe method easily performed by house staff. It is less burdensome than other described endoscopic techniques and does not require patient transfer or fluoroscopic facilities. 相似文献
994.
A quantitative spectrophotometric method has been developed for determining the impurity of isonaphthazarin in samples of
tetraxolin. The relative error of determination is about 1.0% at a confidence probability of P = 0.95%. The procedure is recommended for the quantitative control of the possible impurity of isonaphthazarin in the parent
substance of tetraxolin.
__________
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 1, pp. 38–40, January, 2007. 相似文献
995.
D. V. Moiseev S. I. Marchenko A. M. Moiseeva T. V. Trukhacheva P. T. Petrov A. I. Zhebentyaev 《Pharmaceutical Chemistry Journal》2007,41(1):25-33
Pyrimidine derivatives are widely used for the treatment of viral diseases and cancer. The analysis of pyrimidine derivatives
is typically performed using various chromatographic techniques, in particular, reversed-phase high performance liquid chromatography
(HPLC). The separation is typically carried out with (7–30)-cm-long C8 and C18 silica gel columns, mainly at room temperature, and a 1–1.5 ml-min eluent flow rate. The column is eluted in an isocratic
or gradient system, and a variety of mobile phases have been proposed. The detection is based on optical absorption or fluorescence
measurements, or makes use of mass spectrometry. Various methods of extraction of pyrimidine derivatives from biological samples
are discussed, and the corresponding detection limits are presented.
__________
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 5, pp. 26–34, May, 2007. 相似文献
996.
Objective: To study the diagnostic value of T2^*-weighted first-pass perfusion imaging in breast tumors. Methods: We analyzed the magnetic resonance imaging (MRI) information along with the pathological and immunohistochemistry results. Magnetic resonance imaging was performed in 28 patients with breast tumor. The time to signal intensity curves were generated according to the T2^*-weighted first-pass perfusion imaging. The curve's maximal signal intensity drop rate and maximal signal intensity decrease time were analyzed and compared with the pathological diagnoses after surgery. Results: Malignant breast lesions showed higher maximal signal intensity drop rate (44.69% ± 17.07 vs. 17.22% ±7.49, P 〈 0.001) than benign lesions, but there was no significant difference of maximal signal decrease time between those two lesions (23.94 s ± 4.92 vs. 20.02 s ± 6.83, P 〉 0.05). Conclusion: The T2^*-weighted first-pass perfusion imaging has enough sensitivity and specificity in breast tumor diagnosis. 相似文献
997.
M. G. Ismailova 《Pharmaceutical Chemistry Journal》2007,41(5):281-284
A new technology is developed for the production of activated charcoal (AU-L) tablets from cotton lignin, a readily available
local raw plant material. The physicochemical and technological properties of the parent substance (powder) have been studied
and the optimum composition of tablets has been determined. The best technological characteristics of both the initial mass
and the ready-to-use tablets are achieved for the composition involving a 3% methyl cellulose gel as a binding component and
microcrystalline cellulose as a filler. The qualitative characteristics of AU-L tablets have been studied and their sorption
capacity has been determined. The new technology will be implemented at the Tashkent Pharmaceutical Plant (Uzfarmprom Company).
__________
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 5, pp. 49–52, May, 2007. 相似文献
998.
Y. O. Karatasso I. V. Logunova M. G. Sergeeva E. N. Nikolaev S. D. Varfolomeev V. V. Chistyakov 《Pharmaceutical Chemistry Journal》2007,41(3):166-169
A highly sensitive method for the quantitative determination of a potential antiarrhythmic drug (OF-7976) in the blood plasma
has been developed. The method is based on the electron spray ionization/mass spectrometry (ESI-MS) technique without preliminary
chromatographic separation and makes use of nibentan as the internal standard. A linear relationship between drug concentration
and the peak intensity of ions of the analyzed substance (m/z = 398) and the internal standard (m/z = 382) is established. The detection limit is 3 ng/(0.5 ml plasma). The method is linear from 3 to 25 ng/(0.5 ml plasma)
with a correlation coefficient of 0.98. The coefficient of variation was less than 7 %.
__________
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 3, pp. 45–48, March, 2007. 相似文献
999.
The amount of protein bound per 1 mL of the perfluorocarbon (PFC) emulsion depends on the emulsifier composition and the particle
size. A relationship between the amount of bound protein on the particle surface and the physicochemical parameters of the
PFC emulsion interaction with the blood serum, which indirectly characterize the surface properties of the PFC particles,
is established.
__________
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 12, pp. 40–43, December, 2007. 相似文献
1000.
Phoebe S. Y. Lo Michael C. F. Tong Dennis A. Revicki Ching Chyi Lee John K. S. Woo Henry C. K. Lam C. Andrew van Hasselt 《Quality of life research》2006,15(5):877-887
Background: The Rhinitis Symptom Utility Index (RSUI), originally developed in the United States, consists of a patient-preference weighting
scheme and a 10-item questionnaire measuring the severity and frequency of rhinitis related symptoms over a 14-day period.
This study aimed to determine whether the Chinese RSUI could adopt the US-based multi-attribute utility function (MAUF) in
scoring rhinitis symptoms. Methods: In a Hong Kong study, 116 Chinese adults with allergic rhinitis completed the RSUI questionnaire and 36-item Short-Form
Health Survey (SF-36) after they had been seen by two otorhinolaryngologists for disease-severity ratings. Respondents then
completed computer-administered direct preference measures, i.e., visual analogue scale (VAS) and standard gamble (SG) assessments.
The VAS and SG data were used to estimate a MAUF for the Chinese-based RSUI. Results: The derived MAUF was somewhat different than the one developed for the US RSUI. Test–retest reliability for the Chinese
RSUI was satisfactory (ICC = 0.71, p<0.001). Scores differentiated among cases with mild, moderate, and severe symptoms (p<0.001); and between those who did and did not require medications to control symptoms (p = 0.031). Findings were significantly correlated with SF-36 domain scores (r = 0.19 to 0.37; p=0.041 to <0.001). When the US-based scoring function was applied to the Chinese subjects, the resulting mean RSUI score was
significantly lower (p<0.001). Comparisons between directly measured VAS and SG scores between the US and Chinese samples, demonstrated significant
differences (all p<0.05), with the US subjects consistently rating rhinitis symptoms as worse than Chinese subjects. Conclusions: The Chinese RSUI has good measurement properties that reflect patient preferences from the Chinese. Results suggest that
there are differences in preference rating between US and Chinese subjects and that use of the US-based preference function
for the RSUI would bias the measurement of rhinitis symptom outcomes in Chinese subjects. 相似文献