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111.
112.
Interpretation of CT scans with PACS image display in stack mode 总被引:4,自引:0,他引:4
113.
114.
Iron promotes DEN initiated GST-P foci in rat liver 总被引:3,自引:0,他引:3
Diethylnitrosamine (DEN) was administered to rats as a single dose, which
is known not to give rise to liver tumours without subsequent promotion.
Iron dextran (Fe/Dex) was then administered parenterally to the animals, to
induce iron overload. At 3 and 6 months after the final Fe/Dex treatments,
livers were examined quantitatively for the numbers of the placental form
of glutathione-S-transferase (GST-P) expressing foci, the area occupied by
these foci and their size distribution. The results demonstrate that iron
not only increased the number of foci after DEN initiation in the rat
liver, but that the area occupied by these lesions increased significantly
between 3 and 6 months after initiation. There is no evidence that iron
increased the number of GST- P expressing foci present in rats not exposed
to DEN. This indicates that iron did not act as an initiator in this rodent
model of liver cancer. The increase in the area of the liver occupied by
the foci in iron and DEN treated rats was due to an increase in the size of
the foci, as well as to an increase in the number of foci. This is the
first demonstration that iron can act as a promoter of DEN initiated
hepatocytes. It also demonstrates that fibrogenesis is not an absolute
requirement for the promotion, by iron, of liver foci in the rat, and that
this could also be the case for iron overload in man. Iron may also act as
a promoter of already initiated hepatocytes in the development of human
liver cancer, as it does in the rat.
相似文献
115.
116.
AG Essen-Steele 《MedR Medizinrecht》2004,22(11):629-631
Ohne Zusammenfassung 相似文献
117.
HK Larsen AG Danielsen D Krustrup K Weismann 《Journal of the European Academy of Dermatology and Venereology》2005,19(5):634-637
Neutrophil dermatosis of the dorsal hands (NDDH) is a recently described skin manifestation regarded as a subset of acute febrile neutrophilic dermatotis (Sweet syndrome). We describe 5 cases with pustular and ulcerative plaques and/or bullae and vesicles of the dorsal hands. Three of the patients also had skin changes at sides other than the hands. Associated conditions were found in two patients, one patient treated with hemo-dialysis for chronic glomerulonephritis, and one patient had suffered from a streptococcal tonsillitis prior to the eruption. Two of the patients had fever, two had neutrophil leucocytosis in peripheral blood and two had elevated sedimentation rates. Histological findings showed signs of vasculitis in biopsies from two of the patients. NDDH is discussed on the basis of prior case reports concerning the subject, and it is concluded that Neutrophil dermatosis of the dorsal hands should be regarded as a localized variety of Sweet syndrome. 相似文献
118.
119.
RG Heine BM Button A Olinsky PD Phelan AG Catto-Smith 《Archives of disease in childhood》1998,78(1):44-48
AIM: To establish the incidence of pathological gastro-oesophageal reflux (GOR) in newly diagnosed infants with cystic fibrosis and to identify clinical predictors of increased reflux. METHODS: 26 infants with cystic fibrosis less than 6 months of age (14 male, 12 female; mean (SEM) age 2.1 (0.21) months, range 0.8 to 5.6 months) underwent prolonged oesophageal pH monitoring (mean duration 27.1 (0.49) hours; range 21.3 to 30.2 hours). Reflux symptoms, anthropometric variables, pancreatic status, meconium ileus, genotype, and chest x ray findings were correlated with pH monitoring data. RESULTS: Five infants (19.2%) had an abnormal fractional reflux time of greater than 10%, seven (26.9%) of 5-10%, and 14 (53.8%) of below 5%. Infants who presented with frequent vomiting had a significantly higher fractional reflux time than infants who had infrequent or no vomiting. There was no significant association between abnormal chest x rays and pathological GOR. Sex, genotype, nutritional status, meconium ileus, and pancreatic enzyme supplementation were not significantly associated with pathological GOR. CONCLUSIONS: About one in five newly diagnosed infants with cystic fibrosis had pathological GOR. Pathologically increased reflux was present before radiological lung disease was established. Apart from frequent vomiting, no useful clinical predictors of pathological reflux were found. 相似文献
120.
J Farquharson EC Jamieson RW Logan MB McFadyen WJ Patrick AG Howatson F Cockburn 《Archives of disease in childhood》1998,79(1):28-32
Abnormal fetal and infant growth have increasingly been correlated with adult onset cardiovascular disease. To date, there is little known about the lipid fatty acid profiles in infant cardiovascular tissue. Therefore, we analysed total lipid fatty acids from thoracic and abdominal aorta intima and media from 24 normally grown sudden infant death syndrome cases. Aorta from small for gestational age (n = 2), failure to thrive from birth (n = 3), and premature (n = 1) infants were also examined. Dihomo-gamma-linolenic acid (C20:3n-6) and oleic acid (C18:1n-9) concentrations were significantly lower in the thoracic than in the abdominal aorta. Similar dietary related differences were found in the subgroup (n = 15) of infants fed on formula milks. Both abdominal and thoracic intimal arachidonic (C20:4n-6) to dihomo-gamma-linolenic acid ratios were greater in the infants with retarded growth after birth than in their normally grown counterparts. Growth restriction in infancy might disrupt the normal accretion of vascular endothelial polyunsaturated fatty acids. 相似文献