ASO Author Reflections: Thoraco-Abdominal Approach with Phrenotomy for Large Liver Tumor in Close Contact with the Vena Cava and the Hepatocaval Confluence

Annals of Surgical Oncology -     

Modification of the brain proteome of Africanized honeybees (Apis mellifera) exposed to a sub‐lethal doses of the insecticide fipronil

Fipronil is a phenylpyrazole insecticide that is widely used in Brazilian agriculture for pest control. Although honeybees are not targets of fipronil, studies indicate that this pesticide can be harmful to honeybees. To assess the effects of fipronil in the brain of Africanized Apis mellifera workers, this study focused on the toxico-proteome profiling of the brain of newly emerged and aged honeybee workers that were exposed to a sub-lethal dose (10 pg fipronil per day. i.e. ¹/₁₀₀ of LD₅₀/bee/day during 5 days) of the insecticide. Proteomic analysis identified 25 proteins that were differentially up-regulated or down-regulated when the fipronil-exposed and non-exposed groups were compared. These proteins are potentially related to pathogen susceptibility, neuronal chemical stress, neuronal protein misfolding, and occurrence of apoptosis, ischemia, visual impairment, damaged synapse formation, brain degeneration, memory and learning impairment. The exposure of honeybees to a very low dose of fipronil, even for a short period of time (5 days), was sufficient to cause a series of important neuroproteomic changes in the brains of honeybees.     

Effects of dietary phosphorus restriction on the production of 1,25(OH)2D3 (calcitriol) in patients with moderated renal failure

Calcitriol deficiency and phosphate retention are two main factors in the pathogenesis of renal hyperparathyroidism. In spite of normal serum levels, phosphate may have an important role even in moderate RI. The aim of this study was to evaluate the effect of dietary phosphorus restriction on serum levels of calcitriol in patients with moderate RI. We studied 21 patients (7 F/14 M); mean age 61.7 +/- 15 years old; corrected creatinine clearance 51.4 +/- 14 ml/m. Serum PTH, calcitriol 25(OH)D3, calcium, phosphorus and urinary excretion of calcium and phosphorus were measured before and after 30 days on phosphorus restricted diet (700 mg/day). RESULTS: [table: see text] CONCLUSIONS: Our patients with moderate RI have elevated serum levels of PTH while calcitriol was in the lower normal range. Dietary phosphorus restriction resulted in a significant decrease in PTH levels and a significant increase in serum calcitriol concentrations. The levels of 25(OH)D3 did not change in this study.     

Analysis of high frequency and low amplitude late potentials in the body surface electrocardiogram, in acute and chronic stages of ischemic cardiopathy

A study to evaluate late potentials (LP) was carried out in 50 patients diagnosed as suffering from coronary heart disease. All the patients were divided into two groups: Group A, was made of 25 patients in the acute period of myocardial infarction, and group B, was made of other 25 patients in the chronic phase, with more of 3 months of evolution from the acute event. Average age in group A was 54.2 years, and 58.1 years in group B. Twenty normal volunteer subjects (group C) were also studied as a reference group. All the subjects in the 3 groups were in normal sinus rhythm, and no one of them showed bundle branch block in the basal ECG. Analysis of the vector magnitude was made for each point of the averaged wave, as the result of the mean root square of the addition of bipolar leads X, Y and Z, using a LP-3000 Fidelity Medical Inc. equipment, with a four poles Butterworth filter. LP were detected in 32% of the patients in group A, and in 56% of the group B (p less than 0.001). No LP was observed in patients of the group C. Concerning the localization of myocardial infarction, maximum CPK value, or Lown's grade of ventricular arrhythmias observed in coronary care unit, or in the 3rd week Holter monitoring, did not show significant statistical correlationship with the presence of LP in group A.(ABSTRACT TRUNCATED AT 250 WORDS)     

Cyclic fatigue resistance of three rotary file systems in a dynamic model after immersion in sodium hypochlorite

Odontology - To evaluate the effect of immersion in 3% sodium hypochlorite solution in the resistance to cyclic fatigue of three nickel–titanium (NiTi) rotary file systems, ProTaper Next...