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排序方式: 共有554条查询结果,搜索用时 15 毫秒
101.
Evelyn Ward BSc RD Monica Hopkins Bnurs MSc PG Dip Ed RSCN RGN Lesley Arbuckle BSc PG Dip RD Nicola Williams BSc MSc RD Lynette Forsythe BSc RD Sylwia Bujkiewicz PhD Barry Pizer MB ChB PhD MRCP FRCPCH Edward Estlin BSc PhD MRCP FRCPCH Susan Picton BM BS BmedSci MRCP FRCPCH 《Pediatric blood & cancer》2009,53(4):570-575
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Vanessa Gibson RGN PG Dip Health Social Research CertEd RNT 《Journal of advanced nursing》1996,23(2):353-356
Transplantation of organs has become the treatment of choice for many conditions, yet there remains a worldwide shortage of donor organs This paper reviews the factors which influence organ procurement It concentrates on the public's and the professional's attitudes and examines the potential role research could play in overcoming these difficulties and thus increasing donor referrals 相似文献
107.
Gambacorti-Passerini C; Grignani F; Arienti F; Pandolfi PP; Pelicci PG; Parmiani G 《Blood》1993,81(5):1369-1375
Fusion proteins present in leukemic cells frequently contain a new amino acid at the fusion point. We tested whether a peptide (BCR1/25) encompassing the fusion region of the hybrid molecule pml/RAR alpha, which is selectively expressed by acute promyelocytic leukemia (APL) cells, can be recognized by human T lymphocytes in vitro. CD4+ lymphocytes, at both polyclonal and clonal level, recognized peptide BCR1/25 in an HLA-DR--restricted fashion on presentation by autologous antigen-presenting cell (APC) or by APC expressing the HLA-DR11 restricting molecule. Control peptides corresponding to the normal pml and RAR alpha proteins were not recognized. One clone (DEG5) also exerted a high and specific cytotoxicity against autologous cells pulsed with BCR1/25. The autologous DE LCL containing a transduced pml/RAR alpha fusion gene and expressing a bcr1 type of the pml/RAR alpha hybrid protein induced the proliferation of DE anti-BCR1/25 T cell clones. It is concluded that the bcr1 type-pml/RAR alpha fusion protein of APL contains an antigenic site, absent from the normal parent molecules and recognized by human CD4+ lymphocytes. 相似文献
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C Hedman AR Andersen PG Andersson NE Gilhus P Kangasniemi J-E Olsson E Strandman K Nestvold J Olesen 《Cephalalgia : an international journal of headache》1988,8(4):279-284
There is little information available concerning whether, and to what extent, migraine-prophylactic agents interfere with the symptoms of migraine attacks. The present study is a placebo-controlled, double-blind study concerning metoprolol in classic migraine. The data refer to the symptoms of single migraine attacks. During metoprolol treatment more attacks were characterized as mild (p = 0.002), and mean global rating (an integrated estimate of headache intensity and of other discomfort) was lower (4.2 versus 5.2, p = 0.003). The mean headache intensity per attack (1.97 versus 2.15) and the mean duration (5.5 versus 6.8 h) were not significantly different. Consumption of analgesics per attack was lower during metoprolol treatment (0.6 versus 1.1; p = 0.02). Attacks with associated symptoms accompanying the headache were fewer during metoprolol treatment (p = 0.014). Total visual and non-visual aura symptoms occurred with similar frequency, but scintillations and paraesthesia were more frequent during metoprolol treatment, whereas speech disturbances were less frequent. In spite of lower consumption of analgesics, the symptoms appeared milder during metoprolol than during placebo. The pattern of changes indicates that metoprolol exerts its action via the sympathetic nervous system; peripheral vasoconstriction is hardly the underlying mechanism of action. 相似文献
110.
Alexander Vesprey Eun Sung Suh Didem Göz Aytürk Xu Yang Miracle Rogers Branden Sosa Yingzhen Niu Ivo Kalajzic Lionel B Ivashkiv Mathias PG Bostrom Ugur M Ayturk 《Journal of bone and mineral research》2021,36(5):1000-1011
Metal implants are commonly used in orthopedic surgery. The mechanical stability and longevity of implants depend on adequate bone deposition along the implant surface. The cellular and molecular mechanisms underlying peri-implant bone formation (ie, osseointegration) are incompletely understood. Herein, our goal was to determine the specific bone marrow stromal cell populations that contribute to bone formation around metal implants. To do this, we utilized a mouse tibial implant model that is clinically representative of human joint replacement procedures. Using a lineage-tracing approach, we found that both Acta2.creERT2 and Tmem100.creERT2 lineage cells are involved in peri-implant bone formation, and Pdgfra- and Ly6a/Sca1-expressing stromal cells (PαS cells) are highly enriched in both lineages. Single-cell RNA-seq analysis indicated that PαS cells are quiescent in uninjured bone tissue; however, they express markers of proliferation and osteogenic differentiation shortly after implantation surgery. Our findings indicate that PαS cells are mobilized to repair bone tissue and participate in implant osseointegration after surgery. Biologic therapies targeting PαS cells might improve osseointegration in patients undergoing orthopedic procedures. © 2021 American Society for Bone and Mineral Research (ASBMR). 相似文献