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81.
MICHEL PAIRET PETER ENGELMANN HUBERTUS VON NICOLAI PASCAL CHAMPEROUX SERGE RICHARD GERHARD RAUBER GÜNTHER ENGELHARDT 《The Journal of pharmacy and pharmacology》1997,49(2):184-186
The effects of ambroxol on the spasmolytic action of clenbuterol were investigated on acetylcholine-induced bronchospasm in guinea-pigs. Ambroxol (50 mg kg?1 day?1) or vehicle was administered orally for 14 days. Approximately 45 min after the final dose on day 14, the animals were anaesthetized and the spasmolytic effects of clenbuterol (3, 6 or 12 μg kg?1 injected intravenously) were determined by use of acetylcholine (40 μg kg?1, i.v.)-induced bronchoconstriction. For both vehicle- and ambroxol-treated animals, a positive linear relationship was observed between the log-dose of clenbuterol and the percent inhibition of bronchospasm. The calculated ED25 of clenbuterol (i.e. the dose producing 25% inhibition of the acetylcholine-induced bronchospasm) was 3.98 μg kg?1 (3.29 to 4.82 μg kg?1, 95% confidence interval) in the presence of ambroxol and 5.81 μg kg?1 (4.98 to 6.79 μg kg?1) in the absence of ambroxol. The linear regressions with or without ambroxol differed from each other (P < 0001) but ran parallel (covariance analysis), enabling us to calculate a relative potency, the value of which was 1.46 (1.16 to 1.84). These results demonstrate that the spasmolytic activity of clenbuterol is significantly improved in animals pretreated with ambroxol. 相似文献
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85.
EUGENE M. BUYS NORBERT M. van HEMEL JOHANNES C. KELDER PASCAL F.H.M. van DESSEL LEX BAKEMA 《Pacing and clinical electrophysiology : PACE》1994,17(12):2292-2296
A high dislodgment rate during long-term atrial pacing using the unipolar sickle-shaped active fixation lead was recently reported; therefore, the long-term results of atrial pacing in 118 consecutive patients with the bipolar sickle-shaped active fixation lead (Biotronik FH60-BP) were evaluated. Between January 1989 and September 1993, 87 leads (74%) were inserted for dual chamber pacing and 31 leads (26%) for atrial pacing only. At the time of implantation, the bipolar atrial electrogram had a mean voltage of 4.4 ± 1.6 mV, whereas the acute atrial threshold was 0.72 ± 0.38 V and 1.46 ± 0.67 ml at 0.5-msec pulse duration and mean resistance 506 ± 79 Ω. Early lead dislodgment (< 1 month after implantation) occurred in 9 patients (7.6%). During a mean follow-up of 21.8 months (median 20.9 months), late dislodgment (> 1 month after implantation) occurred in 6 patients (5.1%) after a mean interval of 7.9 months (range 3–14 months). Due to the unacceptably high late dislodgment rate, which to date remains unexplained, new implants of this lead are not recommended. 相似文献
86.
Apical versus Non‐Apical Lead: Is ICD Lead Position Important for Successful Defibrillation? 下载免费PDF全文
GUY AMIT M.D. M.P.H. JIA WANG M.Sc. STUART J. CONNOLLY M.D. MICHAEL GLIKSON M.D. STEPHAN HOHNLOSER M.D. DAVID J. WRIGHT M.D. JOHANNES BRACHMANN M.D. PASCAL DEFAYE M.D. JOERG NEUZNER M.D. PHILIPPE MABO M.D. LISELOT VANERVEN M.D. XAVIER VINOLAS M.D. GILLES O‘HARA M.D. JOSEF KAUTZNER M.D. URSULA APPL B.S.B.M.E. FREDRIK GADLER M.D. Ph.D. KENNETH STEIN M.D. YUVAL KONSTANTINO M.D. JEFF S. HEALEY M.D. M.Sc. 《Journal of cardiovascular electrophysiology》2016,27(5):581-586
87.
JOCELYNE BRUN GENEVIEÉVE CHAMBA YADH KHALFALLAH PASCAL GIRARD ISABELLE BOISSY HÉLEÉNE BASTUJI GENEVIEÉVE SASSOLAS & BRUNO CLAUSTRAT 《Journal of sleep research》1998,7(2):105-114
Modafinil is an alerting substance which has been used successfully to treat narcolepsy. Nothing is known about its effect on hormone secretions. For this purpose, eight healthy young men were enrolled in a double blind trial to test the effects of modafinil on daily plasma melatonin, cortisol and growth hormone (GH) rhythms. Blood was sampled for hormone assays, every hour during the daytime and every 30 min during the nighttime. In addition, rectal temperature and mental performances were determined during the study which comprised 3 sessions, two weeks apart: a 24 h control session including a night with sleep (S1) and two 48 h sessions S2 and S3 with a sleep-deprived night (N1) followed by a recovery night (N2). Modafinil (300 mg2) or placebo were randomly attributed during N1 at 22 h and 8 h.
As expected, performance was improved after modafinil administration and body temperature was maintained or increased. Plasma melatonin and cortisol profiles were similar after modafinil and placebo administration. The levels observed during the recovery and the control nights (N2) displayed no difference. For GH, during both sleep deprived nights, secretion was dramatically reduced compared with the control one, although the number of secretory episodes was unchanged.
These data show that the alerting property of modafinil is not related to an alteration of hormone profiles and suggest that the acute modafinil administration is devoid of short-term side-effects. 相似文献
As expected, performance was improved after modafinil administration and body temperature was maintained or increased. Plasma melatonin and cortisol profiles were similar after modafinil and placebo administration. The levels observed during the recovery and the control nights (N2) displayed no difference. For GH, during both sleep deprived nights, secretion was dramatically reduced compared with the control one, although the number of secretory episodes was unchanged.
These data show that the alerting property of modafinil is not related to an alteration of hormone profiles and suggest that the acute modafinil administration is devoid of short-term side-effects. 相似文献
88.
CATHERINE RUBAT PASCAL COUDERT PIERRE BASTIDE PIERRE TRONCHE 《The Journal of pharmacy and pharmacology》1995,47(2):162-170
The potential antidepressant effects of two pyridazine derivatives, 5-benzyl 6-methyl 2-[4-(3-trifluoro-methyl phenyl) piperazin-1-yl] methylpyridazin-3-one (PC4) and 5-benzyl 6-methyl 2-[4-(3-chlorophenyl) piperazin-1-yl] methylpyridazin-3-one (PCI3), were evaluated using classical psychopharmacological tests in mice. The intraperitoneal LD50 values of PC4 and PC13 were respectively 1125·8 and 429-6mg kg?1. Only at intraperitoneal doses of 100mg kg?1 did PC4 or PC13 significantly decrease locomotor activity. Both compounds (5–20 mg kg?1, i.p.) reduced the duration of immobility of mice in the forced swimming test, antagonized reserpine (2–5 mg kg?1, i.p.)-induced ptosis, and potentiated reserpine (2–5 mg kg?1, i.p.)-induced hypothermia. PC4 and PCI3 (20mg kg?1, i.p.) partly reversed hypothermia induced by low dose apomorphine (5 mg kg?1, s.c.) but were less effective for higher doses of apomorphine (16 mg kg?1, s.c). At 200 mg kg?1, intraperitoneal PC13 enhanced the toxic effects of yohimbine (30 mg kg?1, s.c), while PC4 was inactive. Head twitches produced either by L-5-hydroxytryptophan (4 mg kg?1, i.p.) in mice pretreated with pargyline (100mg kg?1, i.p.) or by 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (3 mg kg?1, i.p.) were antagonized by both pyridazine derivatives (20 mg kg?1, i.p.). PC4 and PC13 showed analgesic properties in the phenylbenzoquinone-induced abdominal constriction test (50 < ED50 < 5-5mg kg?1, i.p.) and in the hot-plate test (10 to 37% of analgesia at 10 mg kg?1, i.p.). These antinociceptive effects were not significantly diminished by naloxone (1 mg kg?1, i.p.). Furthermore, acute intraperitoneal administration of both compounds (20 mg kg?1 for PC4 and 5mg kg?1 for PC13) potentiated morphine (7–5 mg kg?1, s.c.) analgesia in the hot-plate test. Thus, these results suggest that PC4 and PC 13 possess potential antidepressant effects related to different aminergic mechanisms, especially at the 5-HT2 receptor level. 相似文献
89.
ARTIFICIAL URETERAL REPLACEMENT FOR URETERAL NECROSIS AFTER RENAL TRANSPLANTATION: REPORT OF 3 CASES
FRANCOIS DESGRANDCHAMPS PASCAL PAULHAC SOPHIE FORNAIRON ERIC DE KERVILLER ALAIN DUBOUST PIERRE TEILLAC ALAIN LE DUC 《The Journal of urology》1998,159(6):1830-1832