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GIORGIO CIONI PIERO D'ALIMONTE FABIO ZERBINATI PAOLO VENTURA ALESSANDRO CRISTANI ANNALISA VIGNOLI RENATO ROMAGNOLI EZIO VENTURA 《Journal of gastroenterology and hepatology》1992,7(4):388-392
Sixteen patients (15 males, aged 48-70) affected by liver cirrhosis and oesophageal varices were subjected to duplex-Doppler ultrasonographic study (DDUS). Four patients (three with a portal thrombosis and one with a hepatofugal portal flow) were excluded from the subsequent pharmacological test. The twelve remaining patients took part in a double blind cross-over study that evaluated the variations of heart rate (HR), mean systemic arterial pressure (SAP), portal vein diameter (PVD), maximal and mean portal flow velocity (PFV) after the administration of either 40 mg of propranolol or placebo per os, on two consecutive days. Propranolol caused no significant variation in mean SAP and in PVD, whereas it reduced the HR from 67.7 +/- 8.0 to 58.4 +/- 7.0 beats/min (mean +/- s.d.; P less than 0.001); the maxPFV dropped from 18.2 +/- 5.4 to 14.0 +/- 3.7 cm/s (P less than 0.001) and the meanPFV dropped from 15.3 +/- 4.1 to 13.2 +/- 3.1 cm/s (P less than 0.005). No significant variation was observed with placebo. After propranolol administration eight patients exhibited a significant maxPFV decrease, whereas the other four patients exhibited only a drop in HR, suggesting either drug inefficacy, inappropriate dosage or inadequate duration of treatment. DDUS is the only non-invasive method for the examination of the portal vein system.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
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LUIGI FEDELE PAOLO VERCELLINI STEFANO BIANCHI DIANA BRIOSCHI MILENA DORTA 《BJOG : an international journal of obstetrics and gynaecology》1990,97(5):393-396
Summary. Twenty-four women with symptomatic multiple uterine myomas were allocated randomly to treatment with buserelin, 1200μg/day intranasally, for 3 months followed by myomectomy ( n = 8) or to immediate myomectomy ( n = 16). Pre-operative treatment with buserelin reduced the mean uterine volume from 432 (SD 165) to 242 (SD 82) ml ( P < 0.01) but intra-operative blood loss and postoperative morbidity were not significantly less in this group. Six months after operation, pelvic examination was normal in all the patients. However, ultrasonography with transvaginal probe demonstrated the presence of myomas of < 1.5 cm in five women (63%) treated pre-operatively with the analogue and in two women (13%) who underwent immediate surgery (P < 0.05). Induction of a period of hypo-oestrogenism before myomectomy seems to favour short-term recurrence of uterine myomas, limiting the efficacy of surgery. 相似文献
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SAKIS THEMISTOCLAKIS M.D. ANTONIO RAVIELE M.D. PAOLO CHINA M.D. CARLO PAPPONE M.D. ROBERTO DE PONTI M.D. AMIRAN REVISHVILI M.D. ETIENNE ALIOT M.D. KARL‐HEINZ KUCK M.D. PER IVAR HOFF M.D.I. DIPEN SHAH M.D. JESúS ALMENDRAL M.D. ANTONIS S. MANOLIS M.D. GIAN‐BATTISTA CHIERCHIA M.D. ALI OTO M.D. RADU G. VATASESCU M.D. MATJAZ SINKOVEC M.D. RICCARDO CAPPATO M.D. 《Journal of cardiovascular electrophysiology》2014,25(10):1074-1081
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PAOLO ANDERLINI DONNA PRZEPIORKA YANG HUH JO LAUPPE PAULA MILLER JANICE SUNDBERG DAVID SEONG RICHARD CHAMPLIN & MARTIN KÖRBLING 《British journal of haematology》1996,93(4):940-942
Seventy-seven normal donors underwent leukapheresis for peripheral blood progenitor cell collection beginning on day 4 ( n = 45) or day 5 ( n = 32) of filgrastim mobilization (12 μg/kg/d). The two groups were comparable for age, weight, blood volumes processed during leukapheresis and target CD34+ cell dose to be collected. The day 5 schedule allowed a more consistent achievement of the target cell dose with one apheresis ( P = 0.005) and resulted in the initial collection of a significantly larger number of CD34+ cells ( P = 0.009). There was no statistically significant difference in the leukapheresis yield of lymphoid subsets and natural killer cells. 相似文献
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Specific immunopathologic data can be found in 95% of patients with pemphigus vulgaris and in 70% of patients with bullous pemphigoid. Antibodies in pemphigus vulgaris can belong to different classes of immunoglobulins and can be destroyed by immunosuppression. Twenty percent of the pemphigus patients had differing results suggesting early recurrence of disease. In patients with bullous pemphigoid, there is great variability in anti-basal zone antibodies. When the disease clears, there is still a wide range of immunologic patterns. 相似文献