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171.
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173.
Van Landeghem G; Haese P; Lamberts L; Barata J; DeBroe M 《Nephrology, dialysis, transplantation》1997,12(8):1692-1698
Background: The association between aluminium and
dialysis encephalopathy and deterioration of the neurological state during
desferrioxamine treatment of dialysis patients is well established. At
present little is known about the speciation and the mechanisms underlying
the element's neurotoxicity. Methods. Aluminium speciation was performed in
cerebrospinal fluid samples of acutely aluminium-intoxicated dialysis
patients using a recently developed high-performance liquid
chromatographic/electro-thermal atomic absorption spectrometric hybrid
method. Results: Baseline cerebrospinal fluid
aluminium levels of samples taken shortly after the intoxication were low
but elevated (5.0±2.0 &mgr;g/l, n=3) as compared to subjects
with normal renal function (<1 &mgr;g/l). In contrast to the
situation noted in serum and to the iron speciation in cerebrospinal fluid,
aluminium was not bound to transferrin but appeared as two distinct
compounds, the main fraction eluting at the elution volume of aluminium
citrate/silicate. The second compound was not identified. Forty-four hours
after desferrioxamine administration the cerebrospinal fluid aluminium
levels had increased up to a concentration of 10.3±2.5
&mgr;g/l (n=3). This was accompanied by a change in the speciation
profile with aluminium appearing at the elution volume of aluminoxamine.
Conclusion: Our findings may contribute to a better
understanding of the neurotoxic effects of aluminium and its
desferrioxamine chelate in dialysis patients. 相似文献
174.
F. M. RAAPHORST R. LANGLOIS VAN DEN BERGH J. L. M. WAAIJER J. M. VOSSEN & M. J. D. VAN TOL 《Scandinavian journal of immunology》1997,46(3):292-297
Fetal B lymphocytes in mice and humans use a limited number of the available VH gene segments. Mouse fetal B cells primarily utilize 3' VH elements, suggesting that the localization of these elements determines their rearrangement frequency. The previously reported non-random usage of human VH genes has been more difficult to explain. In this study the authors analysed the expression of the most proximal 3' human VH element (VH 6) using a monoclonal antibody (JE-6). VH 6 expression was assessed in various B cell differentiation stages from fetal liver, bone marrow and spleen at 12–20 weeks of gestation. The authors demonstrate that the level of VH 6 expression does not exceed a stochastic usage frequency. This suggests that the localization of VH 6 does not significantly promote its expression during human fetal life, and that other factors must affect the usage of VH genes during human fetal development. 相似文献
175.
结肠腺瘤与腺癌p53,c—erbB2蛋白及CEA的表达和意义 总被引:1,自引:0,他引:1
应用免疫组化法检测15例正常结肠粘膜,40例结肠瘤及40例结肠癌组织的p53,c-erbB2和CEA的表达。结果发现:结肠癌患者p53,c-erbB2及CEA的阳性表达率均显著高于腺瘤(P〈0.01)。p53阳性表达在不典型增生腺瘤患者中,重度显著高于轻度病例(P〈0.01);在结肠腺癌患者中低分化显著高于高分化病例(P〈0.05);CEA的新型单克隆抗体col-1对结肠癌的敏感性和特异性均高,阳 相似文献
176.
177.
The authors aimed at evaluating the impact of psychotraumas in psychiatric outpatients. One hundred forty psychiatric outpatients were consecutively included, without distinction of their current pathology. They filled in an inventory of potentially traumatic experiences, a psychological dissociative experiences scale, a somatoform dissociative experiences questionnaire, and underwent a structured interview for diagnosis of posttraumatic stress disorder (according to the DSM-IV). One hundred subjects related psychological trauma, and 76 patients suffered from posttraumatic stress disorder. Dissociative disorders are found significantly correlated with traumatic experience and to posttraumatic stress disorder. The traumatic impact is found more substantial as the number of events was elevated. This study confirms the elevated prevalence of the psychological traumas and psychotraumatic aftermaths in outpatients of a department of psychiatry, independently from the mental disorder. 相似文献
178.
Duration of the speech disfluencies of beginning stutterers 总被引:1,自引:0,他引:1
P M Zebrowski 《Journal of speech and hearing research》1991,34(3):483-491
This study compared the duration of within-word disfluencies and the number of repeated units per instance of sound/syllable and whole-word repetitions of beginning stutterers to those produced by age- and sex-matched nonstuttering children. Subjects were 10 stuttering children [9 males and 1 female; mean age 4:1 (years:months); age range 3:2-5:1), and 10 nonstuttering children (9 males and 1 female; mean age 4:0; age range: 2:10-5:1). Mothers of the stuttering children reported that their children had been stuttering for 1 year or less. One 300-word conversational speech sample from each of the stuttering and nonstuttering children was analyzed for (a) mean duration of sound/syllable repetition and sound prolongation, (b) mean number of repeated units per instance of sound/syllable and whole-word repetition, and (c) various related measures of the frequency of all between- and within-word speech disfluencies. There were no significant between-group differences for either the duration of acoustically measured sound/syllable repetitions and sound prolongations or the number of repeated units per instance of sound/syllable and whole-word repetition. Unlike frequency and type of speech disfluency produced, average duration of within-word disfluencies and number of repeated units per repetition do not differentiate the disfluent speech of beginning stutterers and their nonstuttering peers. Additional analyses support findings from previous perceptual work that type and frequency of speech disfluency, not duration, are the principal characteristics listeners use in distinguishing these two talker groups. 相似文献
179.
Facial reanimation after acoustic neuroma excision is currently accomplished using a variety of surgical techniques. A multi-institutional survey of patient perceptions of facial reanimation success was accomplished by mailing a questionnaire to 809 randomly selected members of the Acoustic Neuroma Association. Four hundred sixty patients who underwent 296 reanimation procedures responded. Facial to hypoglossal nerve anastomosis, tarsorrhaphy, and upper eyelid implants were most frequently performed. The patient's estimations of initial deficit, spontaneous recovery, and overall satisfaction with the reanimation procedures are discussed. 相似文献
180.
G C Conoscenti S Alberico P Bogatti A Maieron L Fischer Tamaro C Gigli 《Minerva ginecologica》1991,43(12):549-553
The Authors examine the correlation between hypertensive disorders of pregnancy and fetal growth. The results of a study of 342 pregnancies, confirm a significant correlation between hypertension and fetal growth retardation. These findings, so evident in moderate and severe hypertension, have also been confirmed in cases of mild hypertension. The medical treatment also in the pregnancies with mild hypertension, and a larger utilisation of operative deliveries, determined a decrease in perinatal mortality and morbidity. 相似文献