全文获取类型
收费全文 | 4081篇 |
免费 | 187篇 |
国内免费 | 42篇 |
专业分类
耳鼻咽喉 | 154篇 |
儿科学 | 241篇 |
妇产科学 | 209篇 |
基础医学 | 340篇 |
口腔科学 | 109篇 |
临床医学 | 324篇 |
内科学 | 1011篇 |
皮肤病学 | 138篇 |
神经病学 | 269篇 |
特种医学 | 150篇 |
外科学 | 662篇 |
综合类 | 70篇 |
预防医学 | 90篇 |
眼科学 | 162篇 |
药学 | 137篇 |
中国医学 | 8篇 |
肿瘤学 | 236篇 |
出版年
2024年 | 3篇 |
2023年 | 29篇 |
2022年 | 40篇 |
2021年 | 95篇 |
2020年 | 73篇 |
2019年 | 82篇 |
2018年 | 117篇 |
2017年 | 86篇 |
2016年 | 148篇 |
2015年 | 177篇 |
2014年 | 188篇 |
2013年 | 231篇 |
2012年 | 328篇 |
2011年 | 350篇 |
2010年 | 175篇 |
2009年 | 155篇 |
2008年 | 346篇 |
2007年 | 361篇 |
2006年 | 331篇 |
2005年 | 277篇 |
2004年 | 249篇 |
2003年 | 184篇 |
2002年 | 154篇 |
2001年 | 26篇 |
2000年 | 18篇 |
1999年 | 16篇 |
1998年 | 13篇 |
1997年 | 7篇 |
1996年 | 11篇 |
1995年 | 8篇 |
1994年 | 4篇 |
1993年 | 2篇 |
1992年 | 6篇 |
1991年 | 3篇 |
1990年 | 2篇 |
1988年 | 1篇 |
1986年 | 2篇 |
1985年 | 1篇 |
1984年 | 5篇 |
1982年 | 2篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1971年 | 1篇 |
排序方式: 共有4310条查询结果,搜索用时 976 毫秒
991.
Ozge Kurmus Aycan Fahri Erkan Berkay Ekici Turgay Aslan Murat Eren 《Arquivos brasileiros de cardiologia》2020,114(3):469
Background:A sizeable proportion of patients have discordant low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C).Objectives:We assessed the relationship between discordance of LDL-C and non-HDL-C and coronary artery disease (CAD) severity.Methods:We retrospectively evaluated the data of 574 consecutive patients who underwent coronary angiography. Fasting serum lipid profiles were recorded, SYNTAX and Gensini scores were calculated to establish CAD complexity and severity. We determined the medians for LDL-C and non-HDL-C to examine the discordance between LDL-C and non-HDL-C. Discordance was defined as LDL-C greater than or equal to the median and non-HDL-C less than median; or LDL-C less than median and non-HDL-C greater than or equal to median. A p value < 0.05 was accepted as statistically significant.Results:LDL-C levels were strongly and positively correlated with non-HDL-C levels (r = 0.865, p < 0.001) but 15% of patients had discordance between LDL-C and non-HDL-C. The percentage of patients with a Gensini score of zero or SYNTAX score of zero did not differ between discordant or concordant groups (p = 0.837, p = 0.821, respectively). Mean Gensini and SYNTAX scores, percentage of patients with Gensini score ≥20 and SYNTAX score >22 were not different from group to group (p = 0.635, p = 0.733, p = 0.799, p = 0.891, respectively). Also, there was no statistically significant correlation between LDL-C and Gensini or SYNTAX scores in any of the discordant or concordant groups. Additionally, no correlation was found between non-HDL-C and Gensini or SYNTAX score.Conclusions:While there was discordance between LDL-C and non-HDL-C (15% of patients), there is no difference regarding CAD severity and complexity between discordant and concordant groups. 相似文献
992.
Protective effects of chronic melatonin treatment against renal injury in streptozotocin-induced diabetic rats 总被引:8,自引:0,他引:8
The aim of this study was to investigate the effects of melatonin as an antioxidant, on prevention and treatment of streptozotocin (STZ)-induced diabetic renal injury in rats. Male Wistar rats were divided into four groups: (1) untreated, (2) melatonin-treated, (3) untreated diabetic (UD), (4) melatonin-treated diabetic (MD). Experimental diabetes was induced by single dose (60 mg/kg, i.p.) STZ injection. For 3 days prior to administration of STZ, melatonin was injected (200 microg/kg/day, i.p.); these injections were continued until the end of the study (4 weeks). Malondialdehyde (MDA) levels as a marker of lipid peroxidation were significantly increased in the renal homogenates of UD animals and decreased after melatonin administration. The activity of the antioxidative enzyme glutathione peroxidase (GSH-Px) was significantly reduced in UD rats. Melatonin treatment reversed STZ-induced reduction of GSH-Px activity without having an effect on blood glucose. Upon histopathological examination, it was observed that the melatonin treatment prevented the renal morphological damage caused by diabetes. Upon immunohistochemical investigation, glomerular anti-laminin beta1 staining decreased in MD rats. Additionally, no tubular anti-IGF-1 staining was observed in melatonin-treated rats. In conclusion, chronically administered melatonin reduced renal injury in STZ-induced diabetic rats and thus it may provide a useful therapeutic option in humans to reduce oxidative stress and the associated renal injury in patients with diabetes mellitus. 相似文献
993.
994.
Ayse Gultekingil Ozlem Teksam Hayriye Hızarcıoğlu Gulsen Burcu Berberoğlu Ates İnci Nur Saltık-Temizel Hülya Demir 《The American journal of emergency medicine》2018,36(4):665-668
Introduction
Gastrointestinal bleeding is a common problem in pediatric emergency department (PED). Some of these patients can lose significant amount of blood which may lead to shock. The aim of this study is to determine the risk factors predicting clinically significant gastrointestinal (GIS) bleeding in patients presenting to PED.Methods
This study was performed prospectively from January 1st 2013 to December 31th 2013 in patients with upper or lower GIS bleeding. Clinically significant GIS bleeding was defined as > 2 g/dL hemoglobin decrease at any time during observation in PED, need for erythrocyte transfusion or need for rapid endoscopic evaluation.Results
105 patients were enrolled, 81 of which were eligible for the study. Twenty two patients (26,8%) had clinically significant GIS bleeding. These patients have significantly more commonly have upper GI bleeding and symptoms of melena, pallor and tachycardia. Initial laboratory findings revealed lower hemoglobin, RBC and albumin levels with higher WBC and BUN levels. They need significantly more nasogastric tube placement and PPI and H2 blocker treatment. Final diagnosis included more gastritis and peptic ulcers. These patients have less hematochezia, less lower gastrointestinal bleeding and less commonly diagnosed as acute gastroenteritis or Mallory Weiss tear as a final diagnosis.Conclusions
Pediatric emergency physicians should be aware of clinical and laboratory parameters of patients with clinically significant GIS bleeding to predict which patients are under risk of life threatening blood loss. Patients who have melena, pallor, tachycardia, anemia and uremia at presentation are more prone to have significant GIS bleeding. 相似文献995.
McMaster RARE‐Bestpractices clinical practice guideline on diagnosis and management of the catastrophic antiphospholipid syndrome
下载免费PDF全文
![点击此处可从《Journal of thrombosis and haemostasis》网站下载免费的PDF全文](/ch/ext_images/free.gif)
K. Legault H. Schunemann C. Hillis C. Yeung E. A. Akl M. Carrier R. Cervera M. Crowther F. Dentali D. Erkan G. Espinosa M. Khamashta J. J. Meerpohl K. Moffat S. O'Brien V. Pengo J. H. Rand I. Rodriguez Pinto L. Thom A. Iorio 《Journal of thrombosis and haemostasis》2018,16(8):1656-1664
Summary
Background
The McMaster RARE‐Bestpractices project group selected the catastrophic antiphospholipid syndrome (CAPS) for a pilot exercise in guideline development for a rare disease.Objectives
The objectives of this exercise were to provide a proof of principle that guidelines can be developed for rare diseases and assist in clinical decision making for CAPS.Patients/Methods
The GIN‐McMaster Guideline Development checklist and GRADE methodology were followed throughout the guideline process. The CAPS guideline was coordinated by a steering committee, and the guideline panel was formed with representation from all relevant stakeholder groups. Systematic reviews were performed for the key questions. To supplement the published evidence, we piloted novel methods, including use of an expert‐based evidence elicitation process and ad hoc analysis of registry data.Results
This paper describes the CAPS guideline recommendations, including evidence appraisal and discussion of special circumstances and implementation barriers identified by the panel. Many of these recommendations are conditional, because of subgroup considerations in this heterogeneous disease, as well as variability in patient values and preferences.Conclusions
The CAPS clinical practice guideline initiative met the objective of the successful development of a clinical practice guideline in a rare disease using GRADE methodology. We expect that clinicians caring for patients with suspected CAPS will find the guideline useful in assisting with diagnosis and management of this rare disease.996.
Sachin Wani Sharad C. Mathur Wouter L. Curvers Vikas Singh Lorenza Alvarez Herrero Sandy B. Hall Ozlem Ulusarac Rachel Cherian Douglas H. McGregor Ajay Bansal Amit Rastogi Basem Ahmed Mandeep Singh Srinivas Gaddam Fiebo J. Ten Kate Jacques Bergman Prateek Sharma 《Clinical gastroenterology and hepatology》2010,8(9):783-788.e2
997.
Cahit Kaçar İlhan Sezer Hilal Kocabaş Hasan Fatih Çay Can Çevikol Erkan Alpsoy Meltem Alkan Melikoğlu Ayşe Akman 《Rheumatology international》2010,30(9):1263-1266
Psoriasis is a skin disorder that is associated with arthritis. Sacroiliac joint involvement is considered to be less frequent
than the other types of psoriatic arthritis. Additionally, the psoriatic sacroiliitis is considered to be asymmetric in general.
We aimed to define the frequency and type of sacroiliac involvement in patients with psoriasis. Patients with psoriasis were
included the study. Characteristics of skin, nail and articular involvement were noted. Psoriasis area and severity index
was calculated. Antero-posterior pelvic X-rays were obtained and graded by two rheumatologists and a radiologist independently.
One hundred and thirty-three patients were included. Thirty-seven of patients (27%) have articular involvement symptomatically.
The sacroiliac joint involvement was observed in 34 (26%) of patients. More than one-half of sacroiliac involvement was bilateral
while less than one-half was in symptomatic patients regarding sacroiliitis. Fifty-seven percentages of all patients have
psoriatic nail involvement. Sacroiliac joint involvement did not show any significant association with psoriatic nail involvement
or the severity of skin disease. We found higher frequency of sacroiliac joint involvement and bilateral sacroiliitis in patients
with psoriasis. This is in contrast to present information about the association of psoriasis and sacroiliitis. These findings
need confirmation by further studies and with more sophisticated techniques such as magnetic resonance imaging. 相似文献
998.
Ramazan Akdemir Ozlem Karakurt Harun Kilic Asuman B. Yesilay Mehmet Dogan Goksel Cagirci Sadik Acikel Nermin Akdemir 《Heart and vessels》2010,25(2):87-91
It is known that primary angioplasty is more effective than thrombolytic therapy for the treatment of ST-segment elevation
acute myocardial infarction. The aim of the present study is to compare the effects of the two strategies on the left ventricular
functions using the Tei index (a combined myocardial performance index). Of 81 patients (11 female, mean age 52.7 ± 11.9 years,
and 70 male, mean age 54.8 ± 11.5 years) matching the selection criteria, 41 patients were treated by primary percutaneous
transluminal coronary angioplasty and stenting (group A, 41 patients) and 40 patients were treated by thrombolytic agents
(streptokinase) (group B, 40 patients). All patients underwent a complete two-dimensional transthoracic echocardiographic
and Doppler study in the left lateral decubitus position from multiple windows. There was no significant difference between
the two groups in isovolumetric contraction time and ejection time. Isovolumetric relaxation time was 95.2 ± 18.4 in group
A and 116.2 ± 28.1 in group B (P = 0.001) and the Tei index was 0.51 ± 0.12 in group A and 0.59 ± 0.16 in group B (P = 0.019). Isovolumetric relaxation time and Tei index were significantly higher in group B. Primary angioplasty is superior
to thrombolytic therapy as assessed by the Tei index even in the first 3 h, with no apparent change in systolic function. 相似文献
999.
Sonmez A Haymana C Tapan S Safer U Celebi G Ozturk O Genc H Dogru T Tasci I Erdem G Taslipinar A Aydogdu A Yilmaz MI Kurt I Kutlu M 《Endocrine》2010,37(3):455-459
The enzyme chitotriosidase (ChT) is secreted by activated macrophages and play active role in human immune response. ChT activity is increased in atherosclerosis in association to the extent of the disease. We investigated the relevance of ChT to endothelial functions and insulin resistance in patients with T2DM. Forty newly diagnosed and untreated patients with T2DM (male 17; age 47.0?±?6.2?years) and 50 healthy volunteers (male 21; age 50.2?±?8.8?years) were enrolled. Plasma asymmetric dimethyl arginine (ADMA) levels were determined by ELISA. ChT activity was measured by the fluorescence method. Insulin resistance was calculated by the HOMA-IR formula. The patients had higher systolic blood pressures, HOMA-IR, ADMA levels, and ChT activities (P?0.001 for all) and lower HDL cholesterol levels (P?=?0.03) than the control group. The ChT activities of the total group were significantly correlated to the age (r?=?0.031, p?=?0.003), ADMA (r?=?0.22, p?=?0.04), and plasma glucose levels (r?=?0.27, p?=?0.01). ChT was the independent determinant of the plasma ADMA levels (r?=?0.26, p?=?0.02). The results of this study show that serum ChT activity is increased in patients with newly diagnosed, untreated, and uncomplicated patients with T2DM. The results also imply that increased ChT activity may be a predictor of endothelial dysfunction. 相似文献
1000.
Diken OE Unculu S Karnak D Cağlayan O Göçmen JS Kayacan O 《The Southeast Asian journal of tropical medicine and public health》2010,41(5):1252-1257
Cotinine is a major metabolite of nicotine. This study was planned to investigate the relationship between bronchoalveolar lavage (BAL) fluid cotinine levels and serum cotinine levels in smokers and nonsmokers with various pulmonary diseases and to investigate whether these levels are affected by passive smoking. Serum and BAL fluid cotinine levels were measured in 27 patients. BAL cotinine levels were measured using a sensitive ELISA kit produced to measure cotinine in saliva. Plates were read by microuant (BioTek, USA) micro plate reader. All patient serum cotinine levels were detectable except for one nonsmoker patient. However, BAL fluid cotinine levels were measurable in only 6 patients (two of them were nonsmokers). A significant positive correlation was seen between serum and BAL fluid cotinine levels (r = 0.726; p = 0.000). Serum cotinine levels were significantly higher in present smokers than non-smokers (21.0 +/- 16.01; 5.35 +/- 7.65; p = 0.004). However, there were no significant differences in BAL fluid cotinine levels between smokers and nonsmokers. Passive smoking can increase nicotine metabolites in serum and other body fluids, including BAL fluid. Since BAL fluid and serum cotinine levels were well correlated, there is no need to use invasive procedures, such as bronchoscopy and expensive, time consuming BAL fluid analyses. Serum cotinine levels can give a rough idea of smoking status. BAL fluid cotinine meaurements should be done for only scientific reasons. 相似文献