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101.
综合重症监护病房院内感染因素分析 总被引:2,自引:0,他引:2
收集综合重症监护病房(综合ICU)181例患者的临床资料,分析综合ICU院内感染的发生率及影响因素,并探讨预防综合ICU院内感染的有效措施。患者均为入院(科)前或入院(科)48h内无感染病例,院内感染率为15.5%(28例),其中胸、腹部外伤及手术后发生率高(分别占各自的53.8%和45.5%),其次为多发伤(26.1%)、脑部病变、外伤、手术后(17.9%)及心肺复苏后(14.3%),心脏手术后最少(2.5%)。病原菌以G ̄-杆菌为主,绿脓杆茵最多。综合分析多种因素,作者认为:综合ICU院内感染的主要因素是患者年龄、病情严重程度及住院和应用机械通气、留置导尿的时间,而患者本身的咳嗽和排痰能力亦不容忽视。鉴于综合ICU病种杂,作者认为更应重视室内空气、仪器设备的消毒,有感染的患者的隔离及医务人员积极采取消毒隔离措施,以防交叉感染。 相似文献
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Overexpression of p53 in hepatocellular carcinomas: A clinicopathological and prognostic correlation 总被引:1,自引:0,他引:1
IRENE O. L. NG EDWARD C. S. LAI ANNIE S. Y. CHAN MIKE K. P. SO 《Journal of gastroenterology and hepatology》1995,10(3):250-255
Abstract Overexpression of the p53 tumour suppressor gene is one of the most common abnormalities in primary human cancers and appears to be a result of point mutation within a highly conserved region of the gene with subsequent encoding for a mutant, more stable protein. In this study, 71 surgically resected hepatocellular carcinomas (HCC) were examined to study the expression of the p53 gene, its relation with clinicopathological parameters and its prognostic significance. Using immunohistochemical detection for mutant p53 protein with monoclonal antibody PAb1801, p53 overexpression was found in 22 tumours (31%) but in none of the non-tumorous liver specimens. Overexpression of p53 was more frequent in tumours with poor cellular differentiation ( P = 0.01), in tumours > 5 cm in diameter ( P = 0.05), and in those with giant cells present ( P = 0.03) and, less significantly, of massive type of Eggel's classification ( P = 0.06). It did not have any significant correlation with hepatitis B or C status, background liver disease or serum α-fetoprotein levels, nor was it related to tumour invasiveness (venous permeation, direct liver invasion and tumour microsatellite formation). In addition, the presence of p53 mutant protein did not influence tumour recurrence or patients' survival rates. The data suggested that p53 mutation in HCC was associated with a later stage of oncogenesis. However, it was not apparently related to tumour invasiveness/aggressiveness and prognosis. 相似文献
105.
P Lenane † DO Sullivan † CO Keane ‡ SO Loughlin† 《Journal of the European Academy of Dermatology and Venereology》2001,15(6):574-577
Laugier and Hunziker described a syndrome consisting of asymptomatic benign areas of hyperpigmentation affecting the lips, buccal mucosa and, in 50%, the fingernails. We report a 67-year-old woman with the clinical features of Laugier-Hunziker syndrome in association with vulval pigmentation. Histology, immunohistochemistry and electron microscopy from the various areas of pigmentation on the body confirmed the benign nature of the pigmentation. We review potential causes of oral and genital pigmentation, and suggest an expansion of the original syndrome described by Laugier and Hunziker to include more widespread areas of benign hyperpigmentation, which may associated. 相似文献
106.
Silver MT Murdock RH Jr Morrill BB Sue SO 《Alimentary pharmacology & therapeutics》1996,10(3):373-380
BACKGROUND: Ranitidine 150 mg q.d.s. is the currently recommended dosage in the United States for the treatment of erosive oesophagitis. To determine whether a higher dose of ranitidine administered less frequently would also be effective in healing erosive oesophagitis, we compared ranitidine 300 mg b.d. with ranitidine 150 mg q.d.s. in the treatment of erosive oesophagitis. METHODS: This multicentre, double- blind, randomized, placebo-controlled study conducted in the United States compared two dosages of ranitidine in 772 patients with endoscopically diagnosed erosive oesophagitis. Patients were treated with ranitidine 300 mg b.d., ranitidine 150 mg q.d.s. or placebo for up to 12 weeks. Endoscopies were repeated after 4, 8 and 12 weeks of treatment. RESULTS: Ranitidine 300 mg b.d. was significantly more effective than placebo in healing erosive oesophagitis at weeks 8 and 12 (51 vs. 36% and 66 vs. 52%, respectively; P < or = 0.004). Significantly higher healing rates were also achieved with ranitidine 150 mg q.d.s. compared with placebo at 4, 8 and 12 weeks (37 vs. 21%, 62 vs. 36% and 77 vs. 52%, respectively; P < 0.001). Healing rates were significantly higher with ranitidine 150 mg q.d.s. than with ranitidine 300 mg b.d. at all scheduled endoscopies (P < or = 0.041). CONCLUSIONS: Ranitidine 300 mg b.d. is effective in healing erosive oesophagitis and may be appropriate as an alternative dosage regimen to ranitidine 150 mg q.d.s. in some patients with erosive oesophagitis. 相似文献
107.
US-guided pseudoaneurysm repair with a compression device 总被引:1,自引:0,他引:1
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109.
G Gustafsson A Kreuger N Clausen S Garwicz J Kristinsson SO Lie PJ Moe M Perkkiö M Yssing UM Saarinen-Pihkala the Nordic Society of Paediatric Haematology Oncology 《Acta paediatrica (Oslo, Norway : 1992)》1998,87(11):1151-1161
In a multinational, population-based study from the five Nordic countries (Denmark, Finland, Iceland, Norway and Sweden), 2648 children below 15 y of age were diagnosed with acute lymphoblastic leukaemia (ALL) in the years 1981-1996. The annual incidence was 3.9/100 000 children and was stable throughout the study period. The development from regional or national protocols to common Nordic treatment protocols for all risk groups was completed in 1992 through a successive intensification of therapy, based on multidrug chemotherapy including pulses of methotrexate in high doses and avoidance of cranial irradiation in most children. For children with non-B-cell ALL ( n = 2602), the event-free survival (p-EFS) increased from 0.53 ± 0.02 (diagnosed 7/81-6/86) to 0.67 ± 0.02 (7/86-12/91) to 0.78 ± 0.02 (1/92-12/96). The corresponding p-EFS values at 5 y were 0.57, 0.70 and 0.78, respectively. The main improvements were seen in the group of children with non-high risk leukaemia, with 5-y p-EFS values increasing from 0.60 to 0.76 and 0.85 for the three periods. In high-risk patients, progress has been moderate, especially in children with high white blood cell values at diagnosis. During the last 5-y period, only 10% of the patients received cranial irradiation in first remission while 90% of the patients received high doses of cytostatic infusions (methotrexate isolated or combined with cytarabinoside) and multiple intrathecal injections of methotrexate as CNS-adjusted treatment without any indication of an increased CNS relapse rate. 相似文献
110.
胰胆管十二指肠乳头X线解剖与胆囊切除后胆源性腹痛 总被引:7,自引:0,他引:7
为研究胆管十二指肠乳头部的X线解剖与胆囊切除后胆源性腹痛发生间的关系,回顾性研究胆囊切除后胆源性腹痛连续ERCR检查76例,术前病变为胆囊结石,慢性胆囊炎,胆管胰腺未发现病变。 相似文献