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81.
Kirsten M Thieme Dietmar Kubein-Meesenburg Dankmar Ihlow Reza Sadat-Khonsari Ovidiu Moldovan Hans N?gerl 《Annals of anatomy》2007,189(4):384-386
In former works, we had proved that test persons with sound temporomandibular joints (TMJs) used a mandibularly fixed hinge axis (MFHA) and were able to pilot the mandible by solely two kinematical degrees of freedom. We wondered if we could evaluate the MFHA the same way for patients who had problems with their TMJs. Actually, the MFHA could be determined likewise. The results could provide information on the reason for the distortion of the movement of the TMJs, which cannot be yielded by X-ray radiographs. 相似文献
82.
Adrian Covic Anca Seica Paul Gusbeth-Tatomir Ovidiu Gavrilovici David J A Goldsmith 《Nephrology, dialysis, transplantation》2004,19(8):2078-2083
BACKGROUND: Health-related quality of life (QoL) in haemodialysis (HD) patients is a significant predictor of mortality and hospitalization. Patients' adaptation to a chronic disease is determined by their beliefs about illness and treatment. In this cross-sectional study we examined the impact of illness representations on QoL of HD patients and the influence of HD duration on this relationship. METHODS: Eighty-two clinically stable HD patients completed the Short Form-36 Health Survey (mean age 47.9+/-12.1, mean treatment duration 72+/-50.6, 53.6% males). Illness representations were assessed by a structured interview containing questions derived from The Revised Illness Perception Questionnaire. RESULTS: Our results indicate a relatively low QoL of HD patients, with an important proportion of patients scoring less than 43 for the physical component summary (65.9%) and less than 51 for the mental component summary (58.5%). HD patients consider their illness as having a chronic course, which they understand and control quite well. A higher personal control is associated with a lower emotional response and a better understanding of the disease. However, the perceived negative consequences of the disease upon patients' personal lives are considerable, as is their emotional response. Four of the six components of illness representations were strongly related to QoL parameters. On multiple regression analysis, between 15 and 31% in the variance of the physical and mental component of QoL was explained by three dimensions of illness representations: the perceived course of the disease, personal control and emotional response. Only the emotional response dimension of the illness representations is related to treatment duration (r = -0.48, P<0.01). CONCLUSION: Our study demonstrates important relationships between illness representations and QoL in end-stage renal disease patients treated by HD. Future research will have to plan for interventions that could alter illness representations in order to confirm the real impact of illness representations upon patients' QoL. 相似文献
83.
84.
Edeltraut Kröger Ovidiu Tatar Isabelle Vedel Anik M. C. Giguère Philippe Voyer Laurence Guillaumie Jean-Pierre Grégoire Line Guénette 《International journal of clinical pharmacy》2017,39(4):641-656
Background Medication non-adherence may lead to poor therapeutic outcomes. Cognitive functions deteriorate with age, contributing to decreased adherence. Interventions have been tested to improve adherence in seniors with cognitive impairment or Alzheimer disease (AD), but high-quality systematic reviews are lacking. It remains unclear which interventions are promising. Objectives We conducted a systematic review to identify, describe, and evaluate interventions aimed at improving medication adherence among seniors with any type of cognitive impairment. Methods Following NICE guidance, databases and websites were searched using combinations of controlled and free vocabulary. All adherence-enhancing interventions and study designs were considered. Studies had to include community dwelling seniors, aged 65 years or older, with cognitive impairment, receiving at least one medication for a chronic condition, and an adherence measure. Study characteristics and methodological quality were assessed. Results We identified 13 interventions, including six RCTs. Two studies were of poor, nine of low/medium and two of high quality. Seven studies had sample sizes below 50 and six interventions focused on adherence to AD medication. Six interventions tested a behavioral, four a medication oriented, two an educational and one a multi-faceted approach. Studies rarely assessed therapeutic outcomes. All but one intervention showed improved adherence. Conclusion Three medium quality studies showed better adherence with patches than with pills for AD treatment. Promising interventions used educational or reminding strategies, including one high quality RCT. Nine studies were of low/moderate quality. High quality RCTs using a theoretical framework for intervention selection are needed to identify strategies for improved adherence in these seniors. 相似文献
85.
Andrzej L. Komorowski Francisco Alba Mesa Małgorzata M. Bała Jerzy W. Mituś Wojciech M. Wysocki 《The Indian journal of surgery》2015,77(3):853-862
Transvaginal access is the most popular natural orifice translumenal technique in the minimally invasive surgery. Reviews on non-gynecological transvaginal approach morbidities reveal that rates vary greatly. A systematic review of transvaginal approach in non-gynecological intraabdominal procedures was carried out to assess the risk of complications. A systematic search was conducted using MEDLINE, EMBASE, PubMed, and the Cochrane Library from the inception of these databases to March 2012. The following keywords were searched: “transvaginal”, “NOTES”, “single incision”, and “single port”. From the total of 231 potentially eligible abstracts, 87 papers were retrieved and evaluated as fulfilling the eligibility criteria. The final analysis included 32 articles. The overall complications rate was 4.4 %, and complications related to the transvaginal port reached 2.4 %. Conversion rate to open surgery was 3.4 %. The incidence of postoperative urinary tract infection was 0.8 %. The mean operative time was 119 min. The mean hospital stay was 3.1 days (range 6 h–12 days). The technique of transvaginal access can offer several advantages for a patient and is associated with an acceptable rate of complications. 相似文献
86.
Johann Bauersachs Tobias Knig Peter van der Meer Mark C. Petrie Denise Hilfiker‐Kleiner Amam Mbakwem Righab Hamdan Alice M. Jackson Paul Forsyth Rudolf A. de Boer Christian Mueller Alexander R. Lyon Lars H. Lund Massimo F. Piepoli Stephane Heymans Ovidiu Chioncel Stefan D. Anker Piotr Ponikowski Petar M. Seferovic Mark R. Johnson Alexandre Mebazaa Karen Sliwa 《European journal of heart failure》2019,21(7):827-843
Peripartum cardiomyopathy (PPCM) is a potentially life‐threatening condition typically presenting as heart failure with reduced ejection fraction (HFrEF) in the last month of pregnancy or in the months following delivery in women without another known cause of heart failure. This updated position statement summarizes the knowledge about pathophysiological mechanisms, risk factors, clinical presentation, diagnosis and management of PPCM. As shortness of breath, fatigue and leg oedema are common in the peripartum period, a high index of suspicion is required to not miss the diagnosis. Measurement of natriuretic peptides, electrocardiography and echocardiography are recommended to promptly diagnose or exclude heart failure/PPCM. Important differential diagnoses include pulmonary embolism, myocardial infarction, hypertensive heart disease during pregnancy, and pre‐existing heart disease. A genetic contribution is present in up to 20% of PPCM, in particular titin truncating variant. PPCM is associated with high morbidity and mortality, but also with a high probability of partial and often full recovery. Use of guideline‐directed pharmacological therapy for HFrEF is recommended in all patients respecting contraindications during pregnancy/lactation. The oxidative stress‐mediated cleavage of the hormone prolactin into a cardiotoxic fragment has been identified as a driver of PPCM pathophysiology. Pharmacological blockade of prolactin release using bromocriptine as a disease‐specific therapy in addition to standard therapy for heart failure treatment has shown promising results in two clinical trials. Thresholds for devices (implantable cardioverter‐defibrillators, cardiac resynchronization therapy and implanted long‐term ventricular assist devices) are higher in PPCM than in other conditions because of the high rate of recovery. The important role of education and counselling around contraception and future pregnancies is emphasised. 相似文献
87.
Patricia Javaloyes
scar Mir Víctor Gil Francisco Javier Martín‐Snchez Javier Jacob Pablo Herrero Koji Takagi Aitor Alquzar‐Arb María Pilar Lpez Díez Enrique Martín Carlos Bibiano Rosa Escoda Cristina Gil Marta Fuentes Guillermo Llopis García Jos María lvarez Prez Alba Jerez Josep Tost Lluís Llauger Rodolfo Romero Jos Manuel Garrido Esther Rodríguez‐Adrada Carolina Snchez Xavier Rossello John Parissis Alexandre Mebazaa Ovidiu Chioncel Pere Llorens 《European journal of heart failure》2019,21(11):1353-1365
88.
Anthony H. Gershlick David E. Kandzari Amerjeet Banning David P. Taggart Marie-Claude Morice Nicholas J. Lembo W. Morris Brown Adrian P. Banning Béla Merkely Ferenc Horkay Ad J. van Boven Piet W. Boonstra Ovidiu Dressler Joseph F. Sabik Patrick W. Serruys Arie Pieter Kappetein Gregg W. Stone 《JACC: Cardiovascular Interventions》2018,11(13):1224-1233
Objectives
The authors sought to determine the extent to which the site of the left main coronary artery (LM) lesion (distal bifurcation versus ostial/shaft) influences the outcomes of revascularization with percutaneous coronary intervention (PCI) versus coronary artery bypass grafting (CABG).Background
Among 1,905 patients with LM disease and site-assessed SYNTAX scores of <32 randomized in the EXCEL (Evaluation of XIENCE Versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization) trial, revascularization with PCI and CABG resulted in similar rates of the composite primary endpoint of death, myocardial infarction (MI), or stroke at 3 years.Methods
Outcomes from the randomized EXCEL trial were analyzed according to the presence of angiographic core laboratory–determined diameter stenosis ≥50% involving the distal LM bifurcation (n = 1,559; 84.2%) versus disease isolated to the LM ostium or shaft (n = 293; 15.8%).Results
At 3 years, there were no significant differences between PCI and CABG for the primary composite endpoint of death, MI, or stroke for treatment of both distal LM bifurcation disease (15.6% vs. 14.9%, odds ratio [OR]: 1.08, 95% confidence interval [CI]: 0.81 to 1.42; p = 0.61) and isolated LM ostial/shaft disease (12.4% vs. 13.5%, OR: 0.90, 95% CI: 0.45 to 1.81; p = 0.77) (pinteraction = 0.65). However, at 3 years, ischemia-driven revascularization occurred more frequently after PCI than CABG in patients with LM distal bifurcation disease (13.0% vs. 7.2%, OR: 2.00, 95% CI: 1.41 to 2.85; p = 0.0001), but were not significantly different in patients with disease only at the LM ostium or shaft (9.7% vs. 8.4%, OR: 1.18, 95% CI: 0.52 to 2.69; p = 0.68) (pinteraction = 0.25).Conclusions
In the EXCEL trial, PCI and CABG resulted in comparable rates of death, MI, or stroke at 3 years for treatment of LM disease, including those with distal LM bifurcation disease. Repeat revascularization rates during follow-up after PCI compared with CABG were greater for lesions in the distal LM bifurcation but were similar for disease isolated to the LM ostium or shaft. 相似文献89.
A pituitary gene encodes a protein that produces differentiation of breast and prostate cancer cells 总被引:1,自引:0,他引:1
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Platica M Ivan E Holland JF Ionescu A Chen S Mandeli J Unger PD Platica O 《Proceedings of the National Academy of Sciences of the United States of America》2004,101(6):1560-1565
A cDNA clone of 1.1 kb encoding a 108-aa polypeptide was isolated from a human pituitary cDNA library by expression cloning. This protein was named tumor differentiation factor (TDF). The recombinant TDF protein and a 20-aa peptide, P1, selected from the ORF of the gene, induced morphological and biochemical changes consistent with differentiation of human breast and prostate cancer cells. Fibroblast, kidney, hepatoma, and leukemic lymphocytic cell lines were unaffected. Breast and prostate cancer cells aggregated in spheroid-like structures within 24 h of exposure to TDF. This effect was abrogated by a specific affinity-purified rabbit polyclonal anti-P1 Ab. E-cadherin expression was increased in a dose-dependent manner by TDF. Treatment of MCF7 cells with TDF led to production of a lactalbumin-related protein. Peptide P1 significantly decreased the growth of androgen-independent DU145 prostate cancer in severe combined immunodeficient mice. The presence of TDF protein in human sera was detected by the anti-P1 Ab, suggesting a role of TDF in endocrine metabolism. The fact that all activities of TDF can be mimicked by a peptide derived from the encoding TDF sequence opens the possibility of therapeutic applications. 相似文献
90.
Anca Drăgănescu Oana Săndulescu Dragoş Florea Ovidiu Vlaicu Anca Streinu-Cercel Dan Oţelea Victoria Aramă Monica Luminiţa Luminos Adrian Streinu-Cercel Maria Niţescu Alina Ivanciuc Rodica Bacruban Daniela Piţigoi 《The Brazilian journal of infectious diseases》2018,22(5):377-386