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101.
Henrieke W. Schutte MD Guido B. van den Broek MD PhD Stefan C. A. Steens MD PhD Rosella P. M. G. Hermens PhD Jimmie Honings MD PhD Henri A. M. Marres MD PhD Matthias A. W. Merkx MD PhD Willem L. J. Weijs MD Anne I. J. Arens MD Adriana C. H. van Engen–van Grunsven MD PhD Carla M. L. van Herpen MD PhD Johannes H. A. M. Kaanders MD PhD Frank J. A. van den Hoogen MD PhD Robert P. Takes MD PhD 《Cancer》2020,126(17):3982-3990
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Gesine Respondek MD Max-Joseph Grimm MD Ines Piot MD Thomas Arzberger MD Yaroslau Compta MD Elisabet Englund MD Leslie W. Ferguson MD Ellen Gelpi MD Sigrun Roeber MD Armin Giese MD Murray Grossman MD David J. Irwin MD Wassilios G. Meissner MD PhD Christer Nilsson MD Alexander Pantelyat MD Alex Rajput MD John C. van Swieten MD Claire Troakes PhD MSc Günter U. Höglinger MD for the Movement Disorder Society–Endorsed Progressive Supranuclear Palsy Study Group 《Movement disorders》2020,35(1):171-176
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Alan Schwartz Melissa J. Margolis Sara Multerer Hilary M. Haftel Daniel J. Schumacher The APPD LEARN–NBME Pediatrics Milestones Assessment Group 《Medical teacher》2016,38(10):995-1002
Background: The Pediatrics Milestones Assessment Pilot employed a new multisource feedback (MSF) instrument to assess nine Pediatrics Milestones among interns and subinterns in the inpatient context.Objective: To report validity evidence for the MSF tool for informing milestone classification decisions.Methods: We obtained MSF instruments by different raters per learner per rotation. We present evidence for validity based on the unified validity framework.Results: One hundred and ninety two interns and 41 subinterns at 18 Pediatrics residency programs received a total of 1084 MSF forms from faculty (40%), senior residents (34%), nurses (22%), and other staff (4%). Variance in ratings was associated primarily with rater (32%) and learner (22%). The milestone factor structure fit data better than simpler structures. In domains except professionalism, ratings by nurses were significantly lower than those by faculty and ratings by other staff were significantly higher. Ratings were higher when the rater observed the learner for longer periods and had a positive global opinion of the learner. Ratings of interns and subinterns did not differ, except for ratings by senior residents. MSF-based scales correlated with summative milestone scores.Conclusion: We obtain moderately reliable MSF ratings of interns and subinterns in the inpatient context to inform some milestone assignments. 相似文献
107.
Laparoscopic and open gastric resections for malignant lesions: A prospective comparative study 总被引:14,自引:4,他引:14
Dulucq JL Wintringer P Stabilini C Solinas L Perissat J Mahajna A 《Surgical endoscopy》2005,19(7):933-938
Background Whereas laparoscopy for benign diseases provides clear advantages over traditional surgery, the benefits of laparoscopic gastric resection for malignant diseases are less clear. The objectives of this study were to compare prospectively the clinical outcomes between completely laparoscopic and open total and partial gastrectomies for malignant diseases and to assess whether laparoscopic gastrectomies obtain adequate margins and follow oncologic principles.Methods Between April 1995 and March 2004, a prospective comparative study was performed comparing eight patients who underwent laparoscopic total gastrectomy with 11 patients who underwent open total gastrectomy, and 16 patients who underwent laparoscopic partial gastrectomy with 17 who patients underwent open partial gastrectomy. Stage, extent of lymphadenectomy, and long-term follow-up were examined. The intraoperative and postoperative details of the two groups were compared.Results The laparoscopic group patients had fewer intraoperative complications while the operative time was similar to that of the open group. Both ambulation and hospital stay were significantly shorter in the laparoscopic groups than in the open groups. The short-term morbidity was lower in the laparoscopic groups and there were no cases of death, whereas one case of postoperative death occurred after an open total gastrectomy. There was no need to convert to open surgery. The number of lymph nodes obtained in the laparoscopic and open procedures was not significantly different. In addition, all resected margins were tumor free in the laparoscopic group, whereas tumor involvement was presented in the margin of one specimen in the open group.Conclusions The totally laparoscopic approach to total and partial gastrectomies had good results and was proven to be a feasible and safe procedure. In addition, the laparoscopic procedures are superior to open surgeries in terms of faster postoperative recovery, shorter hospital stay, and better cosmetic outcomes. A totally laparoscopic approach for early and advanced gastric cancer can obtain adequate margins and follow oncologic principles. 相似文献
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Omid Ahmadi Martha De L Nicholson Maree L Gould Allan Mitchell Mark D Stringer 《Journal of gastroenterology and hepatology》2010,25(2):277-285
Background and Aims: Interstitial cells of Cajal (ICC) are distributed with smooth muscle throughout the gastrointestinal tract and are involved in regulating motility. ICC were recently discovered in the wall of the human gallbladder. This study sought to determine whether ICC are present in human bile ducts. Methods: Biliary tract samples were obtained from several sources: surgical specimens (n = 16, 11 women, mean age 61 years); archival post‐mortem specimen (n = 1, 86 years, man); and cadavers (n = 2, 68 and 80 years, men). Paraffin‐embedded sections (3 µm) from the gallbladder (fundus, body and neck) and both extrahepatic and intrahepatic bile ducts were investigated. A double immunofluorescence protocol using polyclonal and monoclonal c‐kit antibodies and mast cell tryptase was used to distinguish c‐kit‐positive cells with typical ICC morphology from c‐kit‐positive mast cells. Small bowel samples were used as positive controls. ICC in the gallbladder were confirmed by ultrastructural study. Results: c‐kit‐positive cells with characteristic ICC morphology were identified in the subepithelial and muscular layers of the gallbladder and extrahepatic bile ducts. They were most prominent within the muscle layer of the extrahepatic bile ducts where they were organized into loosely arranged laminae running parallel to circular smooth muscle fibers. ICC were not found in intrahepatic bile ducts. Conclusion: This study demonstrates for the first time that ICC are present in human extrahepatic bile ducts where they are more densely aggregated than in the gallbladder. This cellular network is likely to be involved in biliary tract motility and its related disorders. 相似文献