Plasma Cyclic AMP and Total Catecholamines during Acute Myocardial Infarction in Man

Abstract. There is marked alteration in endocrine activity during acute myocardial infarction (AMI). Many of the hormones involved act by changing target cell concentrations of adenosine 3': 5' monophosphate (cyclic AMP). Since cyclic AMP can escape from cells, changes in intracellular concentrations of the nucleotide may be reflected in changes in plasma levels. The purpose of this study was to determine whether plasma cyclic AMP concentrations alter during the development of AMI.–Elevation of plasma cyclic AMP concentrations was noted during the first few hours following the onset of symptoms of AMI. The highest concentrations, recorded in a group of four patients with shock, showed a range of 54–193 pmol/ml which was significantly elevated compared to the normal range of 9–22 pmol/ml. This increase in plasma cyclic AMP correlated significantly and positively with plasma concentrations of total catecholamines. Patients with the worst prognosis had the highest plasma concentrations of cyclic AMP and total catecholamines.     

Six generations of ill-used children in a Huntington's pedigree

This Huntington''s pedigree of six generations illustrates the interaction of environmental and genetic factors causing prolonged suffering to children reared in such families.     

Multicentric squamous-cell carcinoma of the upper aerodigestive tract

In an attempt to define the true frequency of multiple primary squamouscell carcinomas of the upper aerodigestive tract, 3 separate population groups were studied. The results of this investigation confirmed the high incidence of multicentric carcinomas in the upper aerodigestive tract, lung, and esophagus. The clinical significance of this phenomenon is discussed, particularly its effect on patient survival and its possible relationship to local tumor recurrence. The value of routine panendoscopy in the initial assessment is stressed as well as the need for a lifelong follow-up of these patients.