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61.
Tomoro Hishiki Hiroshi Horie Yasuyuki Higashimoto Katsumi Yotsumoto Shugo Komatsu Yuri Okimoto Harumi Kakuda Yuichi Taneyama Takeshi Saito Keita Terui Tetsuya Mitsunaga Mitsuyuki Nakata Hidemasa Ochiai Moeko Hino Kumiko Ando Hideo Yoshida Jun Iwai 《Pediatric surgery international》2014,30(9):919-926
Purpose
In the recent years in Japan, an increasing number of patients with neuroblastoma (NB) are being treated by the “delayed local treatment (DL)” policy, undergoing surgery after the completion of high-dose chemotherapy with hematopoietic stem cell rescue (HDC). We reviewed the histopathological findings of second-look operations, including those of patients treated with DL.Patients
From 1998 to 2013, 26 patients with high-risk NB underwent radical operation following chemotherapy. Surgery was performed after induction chemotherapy in 17 cases (standard; STD), whereas 9 cases completed induction chemotherapy and HDC before undergoing tumor resection (DL). The amount of necrosis and the degree of differentiation within the post-treatment tumor were assessed.Results
Eighty-eight percent of the tumors showed necrosis in more than 1/3 of the specimen. Two DL cases showed complete disappearance of viable tumor cells. Amount of necrosis did not affect the prognosis of the patient. Tumors with immature, poorly differentiated phenotypes showed an extremely aggressive thereafter. Though not statistically proven, 123I-MIBG (metaiodobenzylguanidine) uptake may be correlated with the amount of viable cells remaining within the tumor, but not with the degree of differentiation.Conclusions
Our results support the previous reports advocating that tumors that sustain unfavorable histology after chemotherapy behave aggressively thereafter. 相似文献62.
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Shigeaki Yasaka Kazunari Murakami Takashi Abe Juro Anan Kazuhiro Mizukami Jin Tanahashi Tadayoshi Okimoto Masaaki Kodama Yoshikuni Kudo Hisanori Kawasaki Toshio Fujioka 《Journal of gastroenterology and hepatology》2009,24(10):1677-1682
Background and Aims: To investigate the utility of a new method of carrying out esophageal manometry using a narrow gauge manometry catheter via a transnasal endoscope.
Methods: The Frequency Scale for the Symptoms of gastroesophageal reflux disease (GERD) (FSSG), a GERD-specific questionnaire, was given to 45 subjects. Subjects
underwent transnasal endoscopy with three dry and three wet (3 mL water) swallows. Direct observations of the primary peristaltic wave and peristaltic pressure measurement were conducted simultaneously.
Results: Endoscopic observation of lower esophageal motility associated with swallowing revealed dilatation of the esophageal lumen after swallowing, followed by contraction in association with the primary peristaltic wave. The peristaltic pressure was significantly lower with increased FSSG scores for dry swallows ( r = −0.347, P = 0.0212), but no significant correlation was seen for wet swallows.
Conclusions: The significant negative correlation between reflux symptoms and peristaltic pressure in dry swallows was thought to be that reduced pressure immediately rostral to the lower esophageal sphincter leads to decreased clearance following gastric acid reflux, playing a large part in the onset of symptoms. 相似文献
Methods: The Frequency Scale for the Symptoms of gastroesophageal reflux disease (GERD) (FSSG), a GERD-specific questionnaire, was given to 45 subjects. Subjects
underwent transnasal endoscopy with three dry and three wet (3 mL water) swallows. Direct observations of the primary peristaltic wave and peristaltic pressure measurement were conducted simultaneously.
Results: Endoscopic observation of lower esophageal motility associated with swallowing revealed dilatation of the esophageal lumen after swallowing, followed by contraction in association with the primary peristaltic wave. The peristaltic pressure was significantly lower with increased FSSG scores for dry swallows ( r = −0.347, P = 0.0212), but no significant correlation was seen for wet swallows.
Conclusions: The significant negative correlation between reflux symptoms and peristaltic pressure in dry swallows was thought to be that reduced pressure immediately rostral to the lower esophageal sphincter leads to decreased clearance following gastric acid reflux, playing a large part in the onset of symptoms. 相似文献
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RA Stein 《Clinical genetics》2009,76(1):21-23
15q13.3 microdeletions increase risk of idiopathic generalized epilepsy
Helbig et al. (2009)
Nature Genetics 41(2):160–162 相似文献
Helbig et al. (2009)
Nature Genetics 41(2):160–162 相似文献
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