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排序方式: 共有547条查询结果,搜索用时 78 毫秒
91.
92.
Christian Probst Frank Hildebrand Martijn van Griensven Hellmut Baur Lutz Mahlke Christian Krettek Hans-Christoph Pape Martin Rolf Wolfgang Grotz 《Injury》2010,41(5):499-505
Background
The goal of this prospective, randomised, double-blind clinical trial study was to assess the effects of dopexamine hydrochloride on organ failure, inflammatory mediators and splanchnic oxygenation in blunt multiple trauma patients at high risk of multiple organ dysfunction syndrome (MODS).Methods
We performed a prospective randomised controlled trial on 30 consecutive blunt multiple trauma patients with ISS ≥ 16, age 18-60 years and initial blood pressure ≥120 mmHg initially admitted to our level I trauma centre. Patients were randomised to treatment with dopamine (n = 15) or dopexamine (n = 15) for 48 h after admission. Outcome in terms of mortality, MODS, splanchnic perfusion, complications, duration of stay was statistically analysed.Results
Dopexamine treatment was associated with impaired organ function and an increased duration of ventilation and ICU stay compared with patients who received dopamine treatment. The acute inflammatory response was increased in the Dopexamine group while a decreased pHi and MEGX formation and increased serum lactate levels were measured.Conclusions
The indication to use dopexamine hydrochloride appears questionable. In the absence of an antiinflammatory effect, dopexamine demonstrated a disadvantageous ICU course in regards to the organ function and the duration of treatment. In addition, a decreased pHi and MEGX formation suggested a deterioration of splanchnic oxygenation. 相似文献93.
94.
Guenther Schneider Hellmut Schürholz Miles A. Kirchin Arno Bücker Peter Fries 《Pediatric radiology》2013,43(2):202-211
Background
Gadolinium-based MR contrast agents have long been considered safe for routine diagnostic imaging. However, the advent of nephrogenic systemic fibrosis (NSF) among certain patients with severe renal insufficiency has brought the issue of safety into question. Nowhere is safety of greater concern than among children who frequently require multiple contrast-enhanced MRI examinations over an extended period of time.Objective
To retrospectively evaluate the safety of gadobenate dimeglumine for contrast-enhanced (CE) MRI across a range of indications.Materials and methods
Two hundred pediatric inpatients (age: 4 days to 15 years) underwent CE MRI as part of clinical routine. The children received a gadobenate dimeglumine dose of either 0.05 mmol/kg body weight (liver, abdominal imaging, musculoskeletal imaging, brain and other rare indications) or 0.1 mmol/kg bodyweight (cardiovascular imaging, MR-urography). Young (< 8 years) children with congenital heart disease were intubated and underwent MRA evaluation with controlled ventilation. Monitoring for adverse events was performed for at least 24 h after each gadobenate dimeglumine injection. Depending on clinical necessity, laboratory measurements and, in some cases, vital sign and ECG determinations were made before and after contrast injection. Safety was evaluated by age group, indication and dose administered.Results
No clinically adverse events were reported among children who had one MRI scan only or among children who had several examinations. There were no changes in creatinine or bilirubin levels even in very young children.Conclusions
No adverse events were recorded during the first 24 h following administration of gadobenate dimeglumine in 200 children. 相似文献95.
Shingo Matsumoto Keita Saito Hironobu Yasui H. Douglas Morris Jeeva P. Munasinghe Martin Lizak Hellmut Merkle Jan Henrik Ardenkjaer‐Larsen Rajani Choudhuri Nallathamby Devasahayam Sankaran Subramanian Alan P. Koretsky James B. Mitchell Murali C. Krishna 《Magnetic resonance in medicine》2013,69(5):spcone-spcone
96.
Christin Gasch Peter Ulz Sigurd Lax Julie Waldispuehl‐Geigl Oliver Mauermann Sumitra Mohan Gunda Pristauz Carolin Lackner Gerald Höfler Florian Eisner Edgar Petru Heinz Sill Hellmut Samonigg Klaus Pantel Sabine Riethdorf Thomas Bauernhofer Jochen B. Geigl Michael R. Speicher 《International journal of cancer. Journal international du cancer》2013,133(2):346-356
97.
The Fontan-operation: from intra- to extracardiac procedure 总被引:2,自引:0,他引:2
Kuroczynski W Kampmann C Choi YH Pruefer D Singelmann J Huth R Schmid FX Heinemann M Oelert H 《Cardiovascular surgery (London, England)》2003,11(1):70-74
PURPOSE: For treatment of univentricular heart, the Fontan operation has been established as the definitive palliation. The current controversy is mainly based on the high incidence of arrhythmias after an intra-atrial lateral tunnel Fontan operation. METHODS: From January 1995 until April 2002, 46 children underwent a Fontan-type operation with or without a small fenestration. In 33 patients (group I) an intracardiac tunnel and in 13 patients (group II) an extracardiac conduit procedure was performed. PRINCIPAL FINDINGS: There was no perioperative mortality. All patients showed postoperative a significant increase of arterial oxygen saturation, from 76 to 86% after surgery with fenestration, or to 90.5% without fenestration respectively. In patients with fenestration procedure, the saturation rose to 90% after closure of fenestrations 9 to 12 months after operation. CONCLUSIONS: Modified Fontan operations can be performed in normothermia on the beating heart with acceptable mortality. The extracardiac conduit Fontan procedure has the benefits of less surgical injury and a higher intraoperative flexibility. 相似文献
98.
Sulochana S. Bhandarkar Marisa Jaconi Levi E. Fried Michael Y. Bonner Benjamin Lefkove Baskaran Govindarajan Betsy N. Perry Ravi Parhar Jamie Mackelfresh Allie Sohn Michael Stouffs Ulla Knaus George Yancopoulos Yvonne Reiss Andrew V. Benest Hellmut G. Augustin Jack L. Arbiser 《The Journal of clinical investigation》2009,119(8):2359-2365
Hemangiomas are the most common type of tumor in infants. As they are endothelial cell–derived neoplasias, their growth can be regulated by the autocrine-acting Tie2 ligand angiopoietin 2 (Ang2). Using an experimental model of human hemangiomas, in which polyoma middle T–transformed brain endothelial (bEnd) cells are grafted subcutaneously into nude mice, we compared hemangioma growth originating from bEnd cells derived from wild-type, Ang2+/–, and Ang2–/– mice. Surprisingly, Ang2-deficient bEnd cells formed endothelial tumors that grew rapidly and were devoid of the typical cavernous architecture of slow-growing Ang2-expressing hemangiomas, while Ang2+/– cells were greatly impaired in their in vivo growth. Gene array analysis identified a strong downregulation of NADPH oxidase 4 (Nox4) in Ang2+/– cells. Correspondingly, lentiviral silencing of Nox4 in an Ang2-sufficient bEnd cell line decreased Ang2 mRNA levels and greatly impaired hemangioma growth in vivo. Using a structure-based approach, we identified fulvenes as what we believe to be a novel class of Nox inhibitors. We therefore produced and began the initial characterization of fulvenes as potential Nox inhibitors, finding that fulvene-5 efficiently inhibited Nox activity in vitro and potently inhibited hemangioma growth in vivo. In conclusion, the present study establishes Nox4 as a critical regulator of hemangioma growth and identifies fulvenes as a potential class of candidate inhibitor to therapeutically interfere with Nox function. 相似文献
99.
Endovascular treatment of acute bleeding complications in traumatic aortic rupture and aortobronchial fistula 总被引:6,自引:0,他引:6
B. Dorweiler C. Dueber A. Neufang W. Schmiedt M. B. Pitton H. Oelert 《European journal of cardio-thoracic surgery》2001,19(6):1202-745
Objective: Herein we report our experience in placement of endovascular stentgrafts in the descending aorta in patients with acute bleeding complications due to traumatic rupture or aortobronchial fistula. Methods: Six patients (one woman, five men, mean age 47±19 years) were treated from September 1995 to February 2000 by implantation of endovascular stentgrafts in the descending aorta. Indications included traumatic ruptures of the aortic isthmus (n=3) and aortobronchial fistulas (n=3). All procedures were performed under general anaesthesia. The implants were introduced under fluoroscopic guidance via the aorta (n=1), the iliac (n=4) or femoral (n=2) artery, respectively. Results: All aortobronchial fistulas and ruptures were sealed up successfully. There was no perioperative morbidity and no procedure-related morbidity except one patient who received aortofemoral reconstruction because of iliac occlusive disease. All patients are alive and well after a mean follow-up of 31 months (range 6–60). Two patients had recurrent hemoptysis, in one case, the patient received a second implant (distal extension), the other patient was managed conservatively. Conclusion: Endovascular treatment by a stentgraft is a safe and reliable procedure in the management of acute bleeding complications in patients with aortic rupture or aortobronchial fistulas. 相似文献