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101.
Sam T. Douthwaite Charlotte Walker Elisabeth J. Adams Catherine Mak Andres Vecino Ortiz Nuria Martinez-Alier Simon D. Goldenberg 《Journal of clinical microbiology》2016,54(1):212-215
The performance of the Enigma MiniLab assay for influenza A and B viruses and respiratory syncytial virus (RSV) was compared to a centralized laboratory respiratory virus panel. The positive and negative percent agreement for influenza A virus, influenza B virus, and RSV were 79.2% (95% confidence interval [95% CI], 57.8 to 92.9%) and 99.4% (95% CI, 98.4 to 99.9), 100% (95% CI, 47.8 to 100%) and 100% (95% CI, 99.3 to 100%), 98.5% (95% CI, 94.6 to 99.8%) and 94.5% (95% CI, 91.9 to 96.4%), respectively. 相似文献
102.
ObjectiveThe study aimed at the assessment of disability in children with headache (n = 1585, 11–14 yrs) from a randomly drawn population based sample. We explored the suitability of the PedMIDAS in epidemiological research by various indicators of response quality. Furthermore, predictors of disability were examined, as well as its association with measures of health care behaviour.MethodsThe PedMIDAS measures functional interference in different domains of life by asking the children for the number of days that their headache partially or totally interfered with their activities.ResultsThe examination of response behaviour revealed a marked attrition of responses (missing, invalid) in two items. As a consequence, the total score for disability could not be obtained for about 25% of the children. Analysis of homogeneity of the PedMIDAS items revealed low item/total correlations in two items. The grading of disability resulted in 81.2% of all children with headache showing no or low disability. Only 1.4% was “severely” disabled. Disability was predicted by frequency, type and intensity of headache. From all psychological variables only dysfunctional stress coping was significantly associated with disability. Disability itself was significantly associated with medical consultation.ConclusionsSuitability of the PedMIDAS for epidemiological research was supported, however with a caveat and recommendations for item revision. Severe disability due to headache was rare in the studied unselected sample when defined by behavioural interference. It is suggested to explore the construct of disability by a multi-method approach, including further instruments assessing headache related distress, (respectively) quality of life. 相似文献
103.
Juan Vera Lourdes Ezpeleta Roser Granero Nuria de la Osa 《Child psychiatry and human development》2010,41(5):465-478
This study examined the prevalence, degree of association and differential effect, by sex and age, of conduct disorder symptoms
on psychopathology and functioning. Participants included 680 Spanish children and adolescents between 8 and 17 years and
their parents, attending to psychiatric outpatient consultation. Data were obtained through structured diagnostic interviews,
and other measures of psychopathological outcomes and functional impairment. In general, the prevalence of antisocial behavior
did not differ significantly by sex or age. Results indicated a higher frequency for 13–17 year olds, and a greater number
of symptoms in boys. Moreover, some symptoms of conduct disorder showed developmental variations. Sex and age differentially
affected the expression of some conduct disorder symptoms and their associations with functional impairment and severity of
psychopathology. Knowing the different expression of each symptom could help to identify these problems in clinical children
and adolescents, contributing to an early detection of population at the highest risk of serious psychopathology and worse
prognosis. 相似文献
104.
Andrés J. Muñoz Nuria Viñolas Ricardo Cubedo Dolores Isla 《Clinical & translational oncology》2011,13(8):592-596
The association between cancer and thrombosis is well established. Venous thromboembolism (VTE) is considered a main cause
of mortality and morbidity in cancer patients and is commonly underestimated by oncologists. In recent years the incidence
rates of VTE have notably increased. Several studies have clearly shown that cancer patients who are diagnosed with VTE present
a poorer prognosis. The Spanish Society of Medical Oncology (SEOM) presents the guidelines for thrombosis and cancer in order
to improve the prevention and management of VTE. 相似文献
105.
Alessandro Pecci Emanuele Panza Daniela De Rocco Nuria Pujol‐Moix Giorgia Girotto Luigi Podda Carmelo Paparo Valeria Bozzi Annalisa Pastore Carlo L. Balduini Marco Seri Anna Savoia 《European journal of haematology》2010,84(4):291-297
MYH9‐related disease (MYH9‐RD) is a rare autosomal dominant disorder caused by mutations in MYH9, the gene encoding the heavy chain of non‐muscle myosin IIA. All patients present congenital macrothrombocytopenia and inclusion bodies in neutrophils. Some of them can also develop sensorineural deafness, presenile cataract, and/or progressive nephropathy leading to end‐stage renal failure. We report four families, each with a novel mutation: two missense mutations, in exons 31 and 32, and two out of frame deletions in exon 40. They were associated with no bleeding diathesis, normal, or only slightly reduced platelet count and no extra‐hematological manifestations, confirming that alterations of the tail domain cause a mild form of MYH9‐RD with no clinically relevant defects. 相似文献
106.
Montserrat Broch José Manuel Gómez Ma Teresa Auguet Nuria Vilarrasa Rosa Pastor Iñaki Elio Montserrat Olona Antonio García-España Cristóbal Richart 《Obesity surgery》2010,20(9):1258-1264
Background
Although the adipokine retinol-binding protein-4 (RBP4) has been implicated in the development of obesity-related insulin resistance, its role in human obesity is still unclear. Our objectives were to find out the effect on RBP4 systemic levels of a weight loss induced by gastric bypass surgery and to analyze RBP4 relationships with insulin resistance, parameters of body composition, lipid metabolism, and inflammation. 相似文献107.
Emilio Ansótegui Barrera Nuria Mancheño Franch Francisco Vera-Sempere José Padilla Alarcón 《Archivos de bronconeumologia》2011,47(2):85-93
Lymphangioleiomyomatosis (LAM) is a rare disease that mainly affects women, particularly those of fertile age. Its presentation is sporadic or associated with tuberous sclerosis complex. It is characterized by an abnormal proliferation of immature smooth muscle cells (LAM cells), which grow aberrantly in the airway, parenchyma, lymph nodes and pulmonary blood vessels and can gradually lead to respiratory failure. It affects several systems, affecting the lymphatic ganglia and causing abdominal tumors. Given its very low prevalence, difficulty in establishing early diagnosis, absence of curative treatment and the difficulty in obtaining information, LAM is placed under the heading of the so-called Rare Diseases. There is a growing interest in the study of this disease which has led to the creation of patient registers and an exponential growth in LAM research, both at a clinical and cellular level. 相似文献
108.
Jesús Villar Nuria Cabrera Milena Casula Carlos Flores Francisco Valladares Mercedes Muros Lluis Blanch Arthur S. Slutsky Robert M. Kacmarek 《Intensive care medicine》2010,36(6):1049-1057
Background
Experimental and clinical studies on sepsis have demonstrated activation of the innate immune response following the initial host–bacterial interaction. In addition, mechanical ventilation (MV) can induce a pulmonary inflammatory response. How these two responses interact when present simultaneously remains to be elucidated. We hypothesized that MV modulates innate host response during sepsis by influencing Toll-like receptor (TLR) signaling. 相似文献109.
Mark Slevin ; Sabine Matou-Nasri ; Marta Turu ; Ana Luque ; Norma Rovira ; Lina Badimon ; Susana Boluda ; Lawrence Potempa ; Coral Sanfeliu ; Nuria de Vera ; Jerzy Krupinski 《Brain pathology (Zurich, Switzerland)》2010,20(1):151-165
Native C-reactive protein (nCRP) is a pentameric oligo-protein and an acute phase reactant whose serum expression is increased in patients with inflammatory disease. We have identified by immunohistochemistry, significant expression of a tissue-binding insoluble modified version or monomeric form of CRP (mCRP) associated with angiogenic microvessels in peri-infarcted regions of patients studied with acute ischaemic stroke. mCRP, but not nCRP was expressed in the cytoplasm and nucleus of damaged neurons. mCRP co-localized with CD105, a marker of angiogenesis in regions of revascularisation. In vitro investigations demonstrated that mCRP was preferentially expressed in human brain microvessel endothelial cells following oxygen-glucose deprivation and mCRP (but not column purified nCRP) associated with the endothelial cell surface, and was angiogenic to vascular endothelial cells, stimulating migration and tube formation in matrigel more strongly than fibroblast growth factor-2. The mechanism of signal transduction was not through the CD16 receptor. Western blotting showed that mCRP stimulated phosphorylation of the key down-stream mitogenic signalling protein ERK1/2. Pharmacological inhibition of ERK1/2 phosphorylation blocked the angiogenic effects of mCRP. We propose that mCRP may contribute to the neovascularization process and because of its abundant presence, be important in modulating angiogenesis in both acute stroke and later during neuro-recovery. 相似文献
110.
Amira Seltana MSc ; Nuria Basora PhD ; Jean-François Beaulieu PhD 《Wound repair and regeneration》2010,18(1):114-122
Rapid and efficient healing of epithelial damage is critical to the functional integrity of the small intestine. Epithelial repair is a complex process that has largely been studied in cultured epithelium but to a much lesser extent in mucosa. We describe a novel method for the study of wound healing using a co-culture system that combined an intestinal epithelial Caco-2/15 cell monolayer cultured on top of human intestinal myofibroblasts, which together formed a basement membrane-like structure that contained many of the major components found at the epithelial–mesenchymal interface in the human intestine. To investigate the mechanism of restitution, small lesions were generated in epithelial cell monolayers on plastic or in co-cultures without disturbing the underlying mesenchymal layer. Monitoring of wound healing showed that repair was more efficient in Caco-2/15–myofibroblast co-cultures than in Caco-2/15 monolayers and involved the deposition of basement membrane components. Functional experiments showed that the addition of type I collagen or human fibronectin to the culture medium significantly accelerated wound closure on epithelial cell co-cultures. This system may provide a new tool to investigate the mechanisms that regulate wound healing in the intestinal epithelium. 相似文献