全文获取类型
收费全文 | 1671篇 |
免费 | 107篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 88篇 |
儿科学 | 46篇 |
妇产科学 | 2篇 |
基础医学 | 167篇 |
口腔科学 | 113篇 |
临床医学 | 100篇 |
内科学 | 461篇 |
皮肤病学 | 31篇 |
神经病学 | 95篇 |
特种医学 | 62篇 |
外科学 | 287篇 |
综合类 | 4篇 |
预防医学 | 67篇 |
眼科学 | 18篇 |
药学 | 106篇 |
中国医学 | 2篇 |
肿瘤学 | 135篇 |
出版年
2022年 | 17篇 |
2021年 | 19篇 |
2020年 | 21篇 |
2019年 | 20篇 |
2018年 | 29篇 |
2017年 | 32篇 |
2016年 | 27篇 |
2015年 | 35篇 |
2014年 | 44篇 |
2013年 | 56篇 |
2012年 | 51篇 |
2011年 | 77篇 |
2010年 | 41篇 |
2009年 | 35篇 |
2008年 | 63篇 |
2007年 | 71篇 |
2006年 | 50篇 |
2005年 | 59篇 |
2004年 | 63篇 |
2003年 | 61篇 |
2002年 | 61篇 |
2001年 | 54篇 |
2000年 | 51篇 |
1999年 | 50篇 |
1998年 | 24篇 |
1997年 | 18篇 |
1996年 | 15篇 |
1995年 | 16篇 |
1994年 | 11篇 |
1993年 | 8篇 |
1992年 | 44篇 |
1991年 | 48篇 |
1990年 | 54篇 |
1989年 | 64篇 |
1988年 | 53篇 |
1987年 | 47篇 |
1986年 | 52篇 |
1985年 | 38篇 |
1984年 | 27篇 |
1983年 | 17篇 |
1982年 | 9篇 |
1979年 | 36篇 |
1977年 | 11篇 |
1976年 | 7篇 |
1975年 | 9篇 |
1974年 | 7篇 |
1972年 | 9篇 |
1971年 | 8篇 |
1968年 | 9篇 |
1966年 | 8篇 |
排序方式: 共有1784条查询结果,搜索用时 15 毫秒
21.
The induction of Epstein-Barr virus (EBV) determined antigens and virus production were observed when the EBV-non producer but genome positive cell line, A2L/AH or AdL, was cocultivated with the fibroblast dominant cells, NPC-fib derived from the primary culture of nasopharyngeal tissues. Such effect was not found when the EBV-genome positive cells were treated with cell free culture medium prepared from the supernatants of cocultivation or cultured medium of NPC-fib cells. It was considered to indicate that intercellular communication influenced the reactivation of EBV genome and promoted the cells for viral productive cycle. The cytoplasmic substances of fibroblastoid cells entered to the cytoplasm of EBV-non producer but genome positive cells, passing through the cell-to-cell membrane channels mediated by intercellular communication, and some of the transferred substances might have promoted EBV production. 相似文献
22.
Kentaro Umeda Daichi Shindo Shinji Somekawa Shinobu Nishitani Wataru Sato Sakiko Toyoda Sachise Karakawa Mika Kawasaki Tomoyuki Mine Katsuya Suzuki 《Nutrients》2022,14(11)
Background: The importance of maintaining good mental health with overall well-being has recently drawn attention from various spheres of academics and the working population. Amino acid intake has been reported to reduce depression symptoms and other mental health problems. However, the effectiveness of amino acid intake (i.e., single or combined) remains unknown. In this study, we assessed a combination of five amino acids (serine, alanine, glutamate, aspartate, and tyrosine; SAGAT) reported to regulate mental health. Methods: A randomized, double-blind, placebo-controlled exploratory trial was conducted. Participants, aged between 20 and 65 years with fatigue sensation, were randomized to receive either SAGAT or the placebo and ingested them for four weeks. A transient mental work was loaded at day 0 and after four weeks of intervention. As the primary outcomes, the fatigue sensation was assessed. The mood status, cognitive function, work efficiency, and blood marker were also measured as secondary outcomes. Results: The number of participants analyzed for the efficacy evaluation were 20 in SAGAT and 22 in the placebo. There were no significant differences in the primary outcomes. However, as the secondary outcomes, the SAGAT group showed a significant improvement in motivation and cognitive function in the recovery period after mental work loaded in a four-week intervention compared to the placebo. Conclusion: The current findings suggest that SAGAT contributes to maintaining proper motivation and cognitive function. Clinical Trial Registration: University Hospital Medical Information Network Clinical Trial Registry (ID: UMIN 000041221). 相似文献
23.
24.
25.
Hasegawa T Ishihara K Takakura S Fujii H Nishimura T Okazaki M Katakami N Umeda B 《Internal medicine (Tokyo, Japan)》2000,39(10):794-797
OBJECTIVE: To determine an appropriate duration for a short course of oral steroids in cases of asthma exacerbations. SETTING: A 1,000 bed city hospital in Kobe, Japan. PATIENTS: Patients with asthma exacerbations who needed hospital admission. METHODS: Following an initial treatment with a 3-day course of intravenous methylprednisolone, patients were allocated to either a 1-week (1 W) or a 2-week (2 W) course of oral prednisolone (PSL, 0.5 mg/kg). OUTCOME MEASURES: Peak expiratory flow rate (PEF) and rate of unscheduled hospital visits and readmission. RESULTS: Twenty patients were enrolled (10 in 1 W, 10 in 2 W). Mean PEF just before starting oral PSL in 1 W and 2 W were 51 and 58% of each patient's best value. PEF was significantly improved and to a similar degree over the course of time in both 1 W and 2 W. The frequency of unexpected hospital visits during a 3-month period after discharge was similar (2 in 1 W and 2 in 2 W). No readmission occurred during the same period. CONCLUSIONS: Because both the 1-week and the 2-week course of oral PSL were equally effective in the treatment of asthma exacerbations, 1 week may be appropriate as the maximum duration of a short rescue course of oral steroids. 相似文献
26.
27.
28.
29.
Hidenori Takahashi Masahiro Umeda Yusuke Takahashi Taiki Matsui Takashi Shigeta Tsutomu Minamikawa Yasuyuki Shibuya Takahide Komori 《The British journal of oral & maxillofacial surgery》2013
Our aim was to investigate the prognosis of patients with squamous cell carcinoma (SCC) of the gingiva who had preoperative dental operations. We studied 102 patients who were being operated on for SCC of the gingiva with special reference to the effects of preoperative dental operations on the prognosis. Twenty-six patients had dental procedures such as tooth extraction, or incision, or curettage before they visited our hospital, while the remaining 76 had no such interventions. The percentage of patients with advanced T stage disease (T3 or T4) was higher among those who had interventions (17/26, 65%) than among those who had not (35/76, 46%). The difference was not significant. Histopathologically invaded nodes were detected in half the patients in the intervention group (13/26), while they were found in only 18/76 (24%) of those in the no intervention group (p < 0.02). The incidence of nodal metastases with extranodal spread was significantly higher in the intervention group than in the no intervention group (p < 0.05), and those in the intervention group were more likely to develop distant metastases than those in the other group (p < 0.001). The 5-year survival in the two groups was 65% and 92%, respectively (p < 0.01). Preoperative dental operations such as tooth extraction, incision, or curettage possibly lead to regional and distant metastases and therefore a poor prognosis in patients with SCC of the gingiva. 相似文献
30.
Takumi Hasegawa Shinshou Ri Masahiro Umeda Hideki Komatsubara Masaki Kobayashi Takashi Shigeta Izumi Yoshitomi Hisazumi Ikeda Yasuyuki Shibuya Izumi Asahina Takahide Komori 《Journal of cranio-maxillo-facial surgery》2013,41(7):558-563
IntroductionIn this study, we investigated whether such a discontinuation of oral bisphosphonate (BP) for 3 months might influence the incidence of BP-related osteonecrosis of the jaw (BRONJ) and wound healing after tooth extraction in patients receiving oral BP therapy.Material and methodsThere were a total of 434 teeth in 201 patients (18 males and 183 females). The patients were divided into two groups depending on whether or not they underwent a 3-month discontinuation of BP therapy (BP? and BP+) before tooth extraction. In this observational study investigated delayed wound healing after tooth extraction in patients receiving oral BP therapy.ResultsIn all cases of the BP? group, there were no BRONJ although there was delayed wound healing in two cases. However, in one case of the BP+ group, oral BP was continued because it was deemed high risk to discontinue treatment by the patient's physician. In this case, an intraoral fistula was still present with bone exposure at 120 weeks after extraction (BRONJ stage 1).ConclusionThis study supports the idea of a drug holiday and encourages further clinical research on this topic of tooth extraction in patients receiving oral BP therapy. 相似文献